Total item
Cart Subtotal
$0.00 Customer Appreciation Sale.
15% off with promo code "APPRECIATION2023" on check out or purchase order
- Henry Aceros, .et al. Celastrol-type HSP90 modulators allow for potent cardioprotective effects, Life Sci, 2019, 2019
- Hiroki Murano, .et al. A purine-type heat shock protein 90 inhibitor promotes the heat shock response in Arabidopsis, Plant Biotechnol Rep, 2017, 11:107-113
Biological Activity
PF-04929113 (SNX-5422) is orally bioavailable heat shock protein 90 (Hsp90) inhibitor.
Targets
| HER2 | HSP90 | |||
| 37 nM | 41 nM(Kd) |
| In vitro (25°C) | DMSO | 90 mg/mL (172.57 mM) | |
| Water | Insoluble | ||
| Ethanol | 4 mg/mL (7.66 mM) | ||
| In vivo | 0.5% CMC+0.25% Tween 80 | 23 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 19.18 mL | 95.88 mL | 191.75 mL |
| 0.5 mM | 3.84 mL | 19.18 mL | 38.35 mL |
| 1 mM | 1.92 mL | 9.59 mL | 19.18 mL |
| 5 mM | 0.38 mL | 1.92 mL | 3.84 mL |
*The above data is based on the productmolecular weight 521.5. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A11074 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 908115-27-5 |
| Formula | C25H30F3N5O4 |
| M. Wt | 521.5 |
| Purity | >98% |
| Synonyms | PF04929113, SNX5422 |
| SMILES | CC1(CC2=C(C(=O)C1)C(=NN2C3=CC(=C(C=C3)C(=O)N)NC4CCC(CC4)OC(=O)CN)C(F)(F)F)C |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
Datasheet
Product Tags
Product Questions
Product Questions
No Questions
Keywords:buy PF-04929113 (SNX-5422) | PF-04929113 (SNX-5422) Supplier | purchase | cost | manufacturer | order | distributor | buy 908115-27-5| 908115-27-5 Supplier | purchase 908115-27-5 | 908115-27-5 cost | 908115-27-5 manufacturer | order 908115-27-5 | 908115-27-5 distributor
Adooq Quality Guarantee
We promise all products perform as described.