PF-04929113 (SNX-5422)

Catalog No.: A11074

Hsp90 inhibitor

PF-04929113 (SNX-5422)

PF-04929113 (SNX-5422) Chemical Structure

CAS NO. 908115-27-5

PF-04929113 (SNX-5422) is orally bioavailable heat shock protein 90 (Hsp90) inhibitor.

Availability: In stock

Package Price Qty
5 mg
$150.00
10 mg
$280.00
50 mg
$600.00
100 mg
$1,050.00
10mM * 1mL in DMSO
$215.00
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Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.
  • Henry Aceros, .et al. Celastrol-type HSP90 modulators allow for potent cardioprotective effects, Life Sci, 2019, 2019
  • Hiroki Murano, .et al. A purine-type heat shock protein 90 inhibitor promotes the heat shock response in Arabidopsis, Plant Biotechnol Rep, 2017, 11:107-113

Biological Activity

PF-04929113 (SNX-5422) is orally bioavailable heat shock protein 90 (Hsp90) inhibitor.
Targets
HER2 HSP90
37 nM41 nM(Kd)
In vitro (25°C) DMSO 104 mg/mL (199.41 mM)
Water <1 mg/mL (<1 mM)
Ethanol 5 mg/mL (9.58 mM)
In vivo 0.5% CMC/0.25% Tween 80 25 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 19.18 mL 95.88 mL 191.75 mL
0.5 mM 3.84 mL 19.18 mL 38.35 mL
1 mM 1.92 mL 9.59 mL 19.18 mL
5 mM 0.38 mL 1.92 mL 3.84 mL

*The above data is based on the productmolecular weight 521.5. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A11074
Actions Inhibitor
M. Wt 521.5
Formula C25H30F3N5O4
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 908115-27-5
Synonyms PF04929113, SNX5422
SMILES CC1(CC2=C(C(=O)C1)C(=NN2C3=CC(=C(C=C3)C(=O)N)NC4CCC(CC4)OC(=O)CN)C(F)(F)F)C

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