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PF-04929113 (SNX-5422)

Catalog No.: A11074

Hsp90 inhibitor

PF-04929113 (SNX-5422)

PF-04929113 (SNX-5422) Chemical Structure

CAS NO. 908115-27-5

PF-04929113 (SNX-5422) is orally bioavailable heat shock protein 90 (Hsp90) inhibitor.

Availability: In stock

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5 mg
10 mg
50 mg
100 mg
10mM * 1mL in DMSO
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Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.
  • Henry Aceros, .et al. Celastrol-type HSP90 modulators allow for potent cardioprotective effects, Life Sci, 2019, 2019
  • Hiroki Murano, .et al. A purine-type heat shock protein 90 inhibitor promotes the heat shock response in Arabidopsis, Plant Biotechnol Rep, 2017, 11:107-113

Biological Activity

PF-04929113 (SNX-5422) is orally bioavailable heat shock protein 90 (Hsp90) inhibitor.
37 nM41 nM(Kd)
In vitro (25°C) DMSO 90 mg/mL (172.57 mM)
Water Insoluble
Ethanol 4 mg/mL (7.66 mM)
In vivo 0.5% CMC+0.25% Tween 80 23 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 19.18 mL 95.88 mL 191.75 mL
0.5 mM 3.84 mL 19.18 mL 38.35 mL
1 mM 1.92 mL 9.59 mL 19.18 mL
5 mM 0.38 mL 1.92 mL 3.84 mL

*The above data is based on the productmolecular weight 521.5. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A11074
Actions Inhibitor
CAS No. 908115-27-5
Formula C25H30F3N5O4
M. Wt 521.5
Purity >98%
Synonyms PF04929113, SNX5422

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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