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PF 429242

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SREBP inhibitor

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Catalog No. A11230

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
PF 429242 10mg A11230-10

Regular Price: $80.00

Special Price: $72.00

PF 429242 25mg A11230-25

Regular Price: $180.00

Special Price: $162.00

PF 429242 50mg A11230-50

Regular Price: $300.00

Special Price: $270.00

PF 429242 100mg A11230-100

Regular Price: $550.00

Special Price: $495.00

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

PF 429242 is a reversible, competitive inhibitor of sterol regulatory element-binding protein (SREBP) site 1 protease.

PF 429242

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Publications citing Adooq Products
PF 429242 Citations (4)
  • Hui Fang,et al. (Pro)renin receptor mediates albumin-induced cellular responses: role of site-1 protease-derived soluble (pro)renin receptor in renal epithelial cells, Am J Physiol Cell Physiol, 2017, Dec 1; 313(6): C632-C643 28903918
  • Tsutomu Nakagawa,et al. Site-1 protease is required for the generation of soluble (pro)renin receptor, J Biochem, 2016, Apr 1;161(4):369-379 28013223
  • Shimada S,et al. Therapeutic effect of post-exposure treatment with antiserum on severe fever with thrombocytopenia syndrome (SFTS) in a mouse model of SFTS virus infection, Virology, 2015, Aug;482:19-27 25817401
  • Jan H. Reiling,et al. A Luman/CREB3-ADP-ribosylation factor 4 (ARF4) signaling pathway mediates the response to Golgi stress and susceptibility to pathogens, Nat Cell Biol., 2013, 15(12): 1473-1485. 24185178

Chemical Information

Catalog Num A11230
Actions Inhibitor
M. Wt 409.56
Formula C25H35N3O2
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 947303-87-9
Synonyms PF-429242, PF429242
SMILES code CCN(CC)CC1=CC=C(C=C1)C(=O)N(CCC2=CC=CC=C2OC)[[email protected]@H]3CCNC3
Chemical Name 4-[(Diethylamino)methyl]-N-[2-(2-methoxyphenyl)ethyl]-N-(3R)-3-pyrrolidinylbenzamide

Biological Activity

Description
PF 429242 is a reversible, competitive inhibitor of sterol regulatory element-binding protein (SREBP) site 1 protease.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 24.42 mL 122.08 mL 244.16mL
0.5 mM 4.88 mL 24.42 mL 48.83 mL
1 mM 2.44 mL 12.21 mL 24.42 mL
5 mM 0.49 mL 2.44 mL 4.88 mL

*The above data is based on the productmolecular weight 409.56. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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