PF 429242

Catalog No.: A11230

SREBP inhibitor

PF 429242

PF 429242 Chemical Structure

CAS NO. 947303-87-9

PF 429242 is a reversible, competitive inhibitor of sterol regulatory element-binding protein (SREBP) site 1 protease.

Availability: In stock

Package Price Qty
10 mg
$80.00
25 mg
$180.00
50 mg
$300.00
100 mg
$550.00
Custom Size Get quote

Free Overnight Delivery on orders over $500

Next day delivery by 10:00 a.m. Order now.

Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.
  • Yang PM, .et al. p38α/S1P/SREBP2 activation by the SAM-competitive EZH2 inhibitor GSK343 limits its anticancer activity but creates a druggable vulnerability in hepatocellular carcinoma, Am J Cancer Res, 2019, Oct 1;9(10):2120-2139 PMID: 31720078
  • Hui Fang, .et al. (Pro)renin receptor mediates albumin-induced cellular responses: role of site-1 protease-derived soluble (pro)renin receptor in renal epithelial cells, Am J Physiol Cell Physiol, 2017, Dec 1; 313(6): C632-C643 PMID: 28903918
  • Tsutomu Nakagawa, .et al. Site-1 protease is required for the generation of soluble (pro)renin receptor, J Biochem, 2016, Apr 1;161(4):369-379 PMID: 28013223
  • Shimada S, .et al. Therapeutic effect of post-exposure treatment with antiserum on severe fever with thrombocytopenia syndrome (SFTS) in a mouse model of SFTS virus infection, Virology, 2015, Aug;482:19-27 PMID: 25817401
  • Jan H. Reiling, .et al. A Luman/CREB3-ADP-ribosylation factor 4 (ARF4) signaling pathway mediates the response to Golgi stress and susceptibility to pathogens, Nat Cell Biol., 2013, 15(12): 1473-1485. PMID: 24185178

Biological Activity

PF 429242 is a reversible, competitive inhibitor of sterol regulatory element-binding protein (SREBP) site 1 protease.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 24.42 mL 122.08 mL 244.16 mL
0.5 mM 4.88 mL 24.42 mL 48.83 mL
1 mM 2.44 mL 12.21 mL 24.42 mL
5 mM 0.49 mL 2.44 mL 4.88 mL

*The above data is based on the productmolecular weight 409.56. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A11230
Actions Inhibitor
M. Wt 409.56
Formula C25H35N3O2
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 947303-87-9
Synonyms PF-429242, PF429242
SMILES CCN(CC)CC1=CC=C(C=C1)C(=O)N(CCC2=CC=CC=C2OC)[[email protected]@H]3CCNC3

Product Tags

Product Tags

Use spaces to separate tags. Use single quotes (') for phrases.

Product Questions

Product Questions

No Questions
Keywords:buy PF 429242 | PF 429242 Supplier | purchase | cost | manufacturer | order | distributor | buy 947303-87-9| 947303-87-9 Supplier | purchase 947303-87-9 | 947303-87-9 cost | 947303-87-9 manufacturer | order 947303-87-9 | 947303-87-9 distributor
Rewards