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PF 429242

Catalog No.: A11230

SREBP inhibitor

PF 429242

PF 429242 Chemical Structure

CAS NO. 947303-87-9

PF 429242 is a reversible, competitive inhibitor of sterol regulatory element-binding protein (SREBP) site 1 protease.

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Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.
  • Kai Xue, .et al. Advanced Oxidation Protein Product Promotes Oxidative Accentuation in Renal Epithelial Cells via the Soluble (Pro)renin Receptor-Mediated Intrarenal Renin-Angiotensin System and Nox4-H2O2 Signaling, Oxid Med Cell Longev, 2021, Nov 26;2021:5710440 PMID: 34873430
  • Tong-bing Wang, .et al. SREBP1 site 1 protease inhibitor PF-429242 suppresses renal cell carcinoma cell growth, Cell Death Dis, 2021, Aug; 12(8): 717 PMID: 34285190
  • Shiying Xie, .et al. Soluble (pro)renin receptor promotes fibrotic response in renal proximal tubule epithelial cells in vitro via Akt/β-catenin/Snail signaling pathway, Am J Physiol Renal Physiol, 2020, Aug 31 PMID: 32865015
  • Yang PM, .et al. p38α/S1P/SREBP2 activation by the SAM-competitive EZH2 inhibitor GSK343 limits its anticancer activity but creates a druggable vulnerability in hepatocellular carcinoma, Am J Cancer Res, 2019, Oct 1;9(10):2120-2139 PMID: 31720078
  • Hui Fang, .et al. (Pro)renin receptor mediates albumin-induced cellular responses: role of site-1 protease-derived soluble (pro)renin receptor in renal epithelial cells, Am J Physiol Cell Physiol, 2017, Dec 1; 313(6): C632-C643 PMID: 28903918
  • Tsutomu Nakagawa, .et al. Site-1 protease is required for the generation of soluble (pro)renin receptor, J Biochem, 2016, Apr 1;161(4):369-379 PMID: 28013223
  • Shimada S, .et al. Therapeutic effect of post-exposure treatment with antiserum on severe fever with thrombocytopenia syndrome (SFTS) in a mouse model of SFTS virus infection, Virology, 2015, Aug;482:19-27 PMID: 25817401
  • Jan H. Reiling, .et al. A Luman/CREB3-ADP-ribosylation factor 4 (ARF4) signaling pathway mediates the response to Golgi stress and susceptibility to pathogens, Nat Cell Biol., 2013, 15(12): 1473-1485 PMID: 24185178

Biological Activity

PF 429242 is a reversible, competitive inhibitor of sterol regulatory element-binding protein (SREBP) site 1 protease.
In vitro DMSO 77 mg/mL (188 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 24.42 mL 122.08 mL 244.16 mL
0.5 mM 4.88 mL 24.42 mL 48.83 mL
1 mM 2.44 mL 12.21 mL 24.42 mL
5 mM 0.49 mL 2.44 mL 4.88 mL

*The above data is based on the productmolecular weight 409.56. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A11230
Actions Inhibitor
CAS No. 947303-87-9
Formula C25H35N3O2
M. Wt 409.56
Purity >98%
Synonyms PF-429242, PF429242
SMILES CCN(CC)CC1=CC=C(C=C1)C(=O)N(CCC2=CC=CC=C2OC)[[email protected]@H]3CCNC3

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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