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Abiraterone (CB-7598) inhibits 17 α-hydroxylase/C17,20 lyase (CYP17A1), an enzyme which is expressed in testicular, adrenal, and prostatic tumor tissues.
Targets
| CYP17 (Cell-free assay) | ||||
| 2 nM |
| In vitro | DMSO | 0.1 mg/mL (<1 mM) | |
| Water | 0.02 mg/mL (<1 mM) | ||
| Ethanol | 0.2 mg/mL (<1 mM) | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 28.64 mL | 143.18 mL | 286.37 mL |
| 0.5 mM | 5.73 mL | 28.64 mL | 57.27 mL |
| 1 mM | 2.86 mL | 14.32 mL | 28.64 mL |
| 5 mM | 0.57 mL | 2.86 mL | 5.73 mL |
*The above data is based on the productmolecular weight 349.2 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
Technical Details
| Catalog Num | A10020 |
|---|---|
| Actions | Inhibitor |
| M. Wt | 349.2 |
| Formula | C24H31NO |
| Solubility | DMSO |
| Purity | >98% |
| Storage | at -20°C 3 years Powder |
| CAS No. | 154229-19-3 |
| Synonyms | CB-7598, CB7598 |
| SMILES | C[[email protected]]12CC[[email protected]@H](CC1=CC[[email protected]@H]3[[email protected]@H]2CC[[email protected]]4([[email protected]]3CC=C4C5=CN=CC=C5)C)O |
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