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Pyruvate Kinase

Pyruvate kinase activators and inhibitors act on the enzyme that catalyzes the final step of glycolysis. Pyruvate kinase transfers phosphate from phosphoenolpyruvate to adenosine diphosphate (ADP), producing pyruvate and adenosine triphosphate (ATP). The M2 isoform (PKM2), expressed in proliferating cells, switches between active tetramers and less active dimers. In 2008 PKM2 was shown to support aerobic glycolysis and tumor growth in xenografts. TEPP-46 and DASA-58 activate PKM2 by promoting tetramer formation, as reported in 2012. Mitapivat is an activator of pyruvate kinase isoforms, including the red blood cell enzyme. Shikonin, listed as (Rac)-Shikonin, and PKM2-IN-1 inhibit PKM2 in studies of cancer cell glycolysis. Several other entries have no direct link to pyruvate kinase.

Items 26-27 of 27

  • PKM2-IN-5
    Cat. No.
    A77429
    CAS No.
    904457-46-1

    PKM2-IN-5

    PKM2-IN-5 is a selective inhibitor of pyruvate kinase M2 (PKM2), a critical enzyme involved in cellular energy metabolism. This compound exhibits potential for modulating glucose metabolism and influencing tumorigenesis by inhibiting PKM2 activity. PKM2-IN-5 is valuable for research applications in cancer biology and metabolic disorders, providing insights into the role of PKM2 in various cellular processes.

    In stock View Details
    1 mg
    $95.00
    5 mg
    $220.00
    All 6 sizes
  • NCGC00188636
    Cat. No.
    A84718
    CAS No.
    1039980-33-0

    NCGC00188636

    NCGC00188636 is a novel covalent inhibitor of pyruvate kinase (PYK). By blocking nucleotide binding at the active site, NCGC00188636 disrupts PYK activity, thereby influencing metabolic processes. This compound is suited for research into the metabolic pathways of various organisms and cell types, providing insights into cellular energy regulation and potential therapeutic targets.

    In stock View Details
    1 mg
    $30.00
    5 mg
    $75.00
    All 5 sizes

Items 26-27 of 27

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