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All Dyes is the single product list for the Fluorescent Dyes, Probes & Stains section. Many dyes here have no application or dye-family subcategory, so the list is the broadest way to browse the range. It suits searches by product name when the required dye is already known. Examples range from the near-infrared cyanine indocyanine green and the ratiometric calcium indicator Fura-2 pentapotassium to the nucleic acid stains Hoechst 33258 trihydrochloride and SYBR Green II. Classical stains such as hematoxylin, reactive labeling dyes and enzyme substrates are listed alongside them. For selection by task or by core structure, the parent Fluorescent Dyes, Probes & Stains page groups dyes by application and dye family.
Synonyms: FITC Biotin
Fluorescein biotin (FITC biotin) is a fluorescent biotin derivative and avidin and streptavidin ligand that contains a FITC fluorophore which displays excitation/emission maxima of 485/535 nm, respectively.
Ds-HAPP is an anthrancenyl and dansyl fluorophore ligand.
DFHO is a fluorogenic ligand specifically designed for binding with the Corn fluorogenic aptamer. With a Kd value of 70 nM, DFHO undergoes a conformational change upon binding, resulting in enhanced fluorescence, thereby facilitating RNA imaging within cellular environments. This compound is valuable for researchers investigating RNA dynamics and localization in live cell assays.
N-Methylmesoporphyrin IX (NMM) is a potent fluorescent binder that targets G-quadruplex DNA, making it an effective probe for studying Aβ fibrillation. It serves as both an in situ inhibitor and an ex situ monitor of Aβ amyloidogenesis in vitro and within cellular contexts. NMM exhibits high sensitivity to G-quadruplex structures while showing negligible response to duplexes, triplexes, and single-stranded DNA. Additionally, it remains nonfluorescent in monomeric Aβ environments, producing strong fluorescence upon interaction with Aβ aggregates.
Synonyms: T1117
Tocrifluor 1117 is a selective fluorescent ligand targeting the GPR55 receptor. This compound serves as a valuable tool in research for visualizing the cellular distribution of cannabinoid receptors, including GPR55, in live tissues. With excitation and emission maxima at 543 nm and 590 nm, respectively, Tocrifluor 1117 enhances the understanding of cannabinoid receptor localization and function in various biological contexts.
SW116 free base is a selective fluorescent ligand for the sigma-2 receptor, exhibiting a binding affinity with a Ki value of 14 nM. This compound displays a maximal excitation wavelength of 333 nm and a maximal emission wavelength of 506 nm when dissolved in methanol. SW116 free base can be internalized by MDA-MB-435 cells, achieving 50% maximum fluorescent intensity within 24 minutes. Due to its properties, it serves as a valuable fluorescent probe in cancer research applications.
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BODIPY-Cyclopamine is a fluorescent ligand targeting the Smoothened (SMO) receptor, crucial for Hedgehog signaling pathway regulation. Dysregulation of this pathway is linked to tumorigenesis, making BODIPY-Cyclopamine valuable for research related to cancer biology. Utilizing the NanoBRET (Nanofluorescein bioluminescence resonance energy transfer) technique, this compound facilitates the sensitive detection of energy transfer between SMO and the fluorescent probe, enabling high-throughput screening and kinetic studies. Additionally, investigating the binding dynamics of BODIPY-Cyclopamine can assist in the development of SMO-targeted therapeutics.
