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Protein Stains & Detection Probes
Browse selected reagents for protein staining, protein detection and documented aggregate-related readouts. Start with the question your assay needs to answer, then check the exact reagent and method. A stain used to visualize proteins, a quantity-related assay reagent and an aggregate-associated probe are different choices; this collection does not present them as interchangeable or as universal protein labels.
Thioflavin T is a cationic benzothiazole dye that selectively binds to β-amyloid fibrils, resulting in a significant increase in fluorescence. The dye exhibits an excitation maximum at approximately 385 nm when unbound and around 450 nm when bound to amyloid, with emission maxima of approximately 445 nm and 485 nm, respectively. It is widely used in research to detect and study amyloid deposition in tissues, contributing to the understanding of neurodegenerative diseases such as Alzheimer's.
Congo Red is an azo dye that specifically binds to amyloid proteins. Its primary application is as a histological stain for the detection of amyloid deposits in tissue sections, facilitating the diagnosis of amyloidosis and related diseases. Additionally, Congo Red is utilized in various research studies to investigate protein aggregation and misfolding, making it a valuable reagent in both clinical and experimental settings.
Brilliant Blue G-250 is a dye that functions as a P2×7 receptor (P2×7R) antagonist. It exhibits selective inhibition of P2×7R, leading to the inactivation of the NLRP3 inflammasome, which is crucial in inflammatory processes. This compound is widely utilized for protein visualization in SDS-PAGE, providing a straightforward staining method alongside high quantitation capabilities in the Bradford protein assay, where protein concentrations are assessed by measuring absorbance at 595 nm.
Brilliant Blue R250 is an anionic dye primarily used for protein detection in SDS-PAGE gels. This dye effectively binds to proteins, providing clear visualization and enabling quantification of protein samples. It is widely utilized in biochemical research for analyzing protein purity and assessing protein molecular weight.
Ponceau S (Acid Red 112) is a non-specific protein staining agent primarily used for visualizing proteins in Western blotting applications. It operates in an acidic aqueous solution, ensuring compatibility with antibody-antigen interactions while effectively staining proteins red on membranes. Ponceau S facilitates the assessment of protein transfer and quantification, making it a valuable tool in various biochemical research settings.
CBQCA is a fluorescent dye specifically designed for the quantitation of proteins. It emits light at 530 nm upon excitation at 488 nm, facilitating the accurate measurement of protein concentrations in various samples. This reagent is widely utilized in biochemical assays and analytical applications that require precise protein quantification.
BSPOTPE is a fluorescent probe that binds selectively to human serum albumin (HSA) through an aggregation-induced emission (AIE) mechanism. It demonstrates significant fluorescence enhancement upon aggregation, making it a valuable tool for studying albumin interactions. BSPOTPE shows minimal fluorescence response to other proteins and DNA, thus ensuring specificity in research applications related to protein binding and bioimaging of HSA.
NEP is a turn-on fluorescent probe utilizing the intramolecular charge transfer (ICT) mechanism for the detection of vicinal dithiol-containing proteins (VDPs). It demonstrates high selectivity for VDPs in live cells and in vivo, emitting a strong green fluorescence signal with excitation and emission wavelengths of 430 nm and 535 nm, respectively. NEP holds potential for advancements in research related to parkinsonism.
(E)-BSPOTPE is the E configuration of BSPOTPE that selectively targets human serum albumin (HSA) and exhibits aggregation-induced emission (AIE) properties. This compound demonstrates significant fluorescence response specifically to albumin, such as HSA and bovine serum albumin (BSA), while displaying negligible responses to other proteins and DNA. (E)-BSPOTPE serves as a valuable fluorescent probe for studying HSA in various biological research applications.
BSB is a Congo red-derived fluorescent probe that specifically targets amyloid β protein in extracellular spaces, as well as abnormal tau and synuclein protein aggregates within cells. Its primary mechanism involves selective binding, allowing for effective visualization of key pathological features associated with neurodegenerative diseases. BSB serves as a valuable imaging agent for Alzheimer's disease research, providing insights into amyloid and tau pathology.
tris-NTA Biotin is a biotin-labeled tris-NTA compound designed for reversible binding to histidine-tagged proteins. It selectively labels proteins and cell surfaces, facilitating studies on protein interactions and localization. This reagent is useful in various research applications, including affinity purification, protein detection, and cellular imaging.
