TRP Channel

Cat. No.

A68889

CAS No.

1192871-27-4

TRPV antagonist 1

TRPV Antagonist 1 is a selective transient receptor potential vanilloid (TRPV) channel antagonist, exhibiting an IC50 of less than 250 nM. This compound effectively inhibits TRPV-mediated calcium influx, making it a valuable tool for investigating TRPV-related signaling pathways. It is applicable in research focused on pain, inflammation, and sensory neuron function, facilitating the study of TRPV channels in various biological contexts.

Cat. No.

A71670

CAS No.

52514-04-2

N-Oleoyl Taurine

N-Oleoyl Taurine is an endogenous metabolite that acts as an amino-acyl endocannabinoid. It is known to activate transient receptor potential (TRP) channels, specifically TRPV1 and TRPV4, implicating its role in calcium signaling. This compound has been isolated from rat brain and presents potential applications in research studying the physiological effects of TRP channel modulation and its involvement in neurological functions.

Cat. No.

A72471

CAS No.

807370-75-8

N-Lignoceroyl Taurine

N-Lignoceroyl Taurine is an endogenous metabolite and taurine conjugate of lignoceric acid, identified through lipidomic analysis of bovine brain. This compound exhibits distinct biological activity as a substrate for fatty acid amide hydrolase (FAAH), with levels significantly elevated in FAAH knockout mice, indicating a potential role in lipid metabolism. Additionally, N-Lignoceroyl Taurine has been shown to activate transient receptor potential (TRP) calcium channels, including TRPV1 and TRPV4, highlighting its relevance in neurobiology and cellular signaling research.

Cat. No.

A73397

CAS No.

184003-14-3

SU200

SU200 is a TRPV1 agonist that modulates intracellular calcium ion concentrations. It induces distinct calcium ion response patterns, displaying notable reactivity and peak efficacy. The effects of SU200 exhibit varying degrees of response delay and variability across different cell types. This compound offers potential avenues for pharmacological development and further research into calcium signaling pathways.

Cat. No.

A74236

CAS No.

67964-87-8

Stearoyl Serotonin

Stearoyl serotonin is a hybrid compound designed to target the endogenous metabolite systems and is structurally derived from arachidonoyl serotonin. This compound is investigated for its ability to function as a dual antagonist of fatty acid amide hydrolase (FAAH) and the TRPV1 channel, which are critical pathways in the modulation of pain. Preliminary studies suggest that modifications to the arachidonoyl structure, such as the introduction of an 18-carbon stearoyl moiety, may influence TRPV1 channel activity; replacement with saturated fatty acids has demonstrated significant inhibition of capsaicin-induced activation. This positions stearoyl serotonin as a potential candidate for research into pain mechanisms and therapeutic applications.

Cat. No.

A92463

CAS No.

852043-37-9

08:0 PI(4,5)P2 ammonium

08:0 PI(4,5)P2 ammonium is a biochemical assay reagent that targets lipid signaling pathways. Its primary application involves probing the binding site at the transient receptor potential vanilloid 4 (TRPV4) N-terminus. This compound facilitates the study of cellular mechanisms influenced by phosphoinositides, contributing valuable insights into TRPV4-related functions in various physiological contexts.

Cat. No.

A96465

CAS No.

112848-19-8

16-HydroxyCapsaicin

16-HydroxyCapsaicin is a natural product derived from chili peppers, exhibiting its biological activity primarily through interaction with TRPV1 (transient receptor potential vanilloid 1) channels. This compound is known for its potential analgesic and anti-inflammatory properties, making it a valuable reagent for research in pain relief and sensory biology. Its unique mechanism of action underscores its relevance in studies exploring the modulation of pain pathways and the physiological responses to capsaicinoids.

Cat. No.

A96731

CAS No.

69173-71-3

17-Hydroxy Capsaicin

17-Hydroxy Capsaicin is a natural product derived from chili peppers, exhibiting significant activity as a vanilloid receptor (TRPV1) agonist. This compound is known to modulate pain perception and has demonstrated anti-inflammatory properties. Its applications in research include exploring mechanisms of pain relief and the development of novel analgesics, making it a valuable tool in pharmacological studies.

Cat. No.

A97332

CAS No.

1177195-52-6

CAY10448

CAY10448 is a 6-Iodonordihydrocapsaicin analogue that selectively modulates the transient receptor potential vanilloid 1 (TRPV1) channel. This compound serves as a valuable tool for research into pain pathways and sensory neuron activation. Its ability to interact with TRPV1 makes it useful for studies investigating pain mechanisms, neuroprotective effects, and the modulation of inflammatory responses.

Cat. No.

B10862

CAS No.

2682864-43-1

KM-001-E2

Synonyms: (S)-KM-001

KM-001-E2 is the (S)-enantiomer of KM-001, a selective antagonist of the TRPV3 channel. This compound plays a significant role in investigating the mechanisms underlying skin itching and keratinization disorders. Its application in research may provide insights into TRPV3-related pathophysiology and potential therapeutic strategies for skin conditions.

Cat. No.

B18377

CAS No.

1687-53-2

5-Amino-2-methoxyphenol

5-Amino-2-methoxyphenol is a phenolic regioisomer that exhibits significant antinociceptive properties. In the mouse formalin test, it demonstrates dose-dependent analgesic effects, with its second-phase action involving both fatty acid amide hydrolase (FAAH) and transient receptor potential vanilloid 1 (TRPV1). This compound is valuable for research focused on pain mechanisms and potential therapeutic applications in pain management.

Cat. No.

B19080

CAS No.

19683-98-8

Ovalicin

Ovalicin is a selective inhibitor of the transient receptor potential vanilloid 1 (TRPV1), exhibiting significant anti-inflammatory and anti-atopic dermatitis effects. It covalently binds to MetAP2, inhibiting its activity and demonstrating efficacy against pathogens such as Enterocytozoon bieneusi. Through the attenuation of LPS-induced calcium influx and modulation of inflammatory gene expression, Ovalicin effectively reduces macrophage and mast cell infiltration in the skin, alleviating allergic symptoms in mouse models. This compound is valuable for research into microsporidiosis and atopic dermatitis.