Guanylate Cyclase

Cat. No.

A60886

CAS No.

2781965-75-9

Nurandociguatum

Synonyms: Nurandociguat

Nurandociguatum is a guanylate cyclase activator that enhances intracellular cGMP levels, leading to vasodilation and modulation of nitric oxide signaling. This compound is primarily utilized in cardiovascular research, particularly in studies investigating pulmonary hypertension and heart failure mechanisms. Its ability to stimulate guanylate cyclase makes it a valuable tool for exploring therapeutic strategies targeting vascular relaxation and nitric oxide pathways.

Cat. No.

A60889

CAS No.

1160426-89-0

GSK2181236A

GSK2181236A is a soluble guanylate cyclase (sGC) activator that is resistant to nitric oxide. This compound promotes vasodilation, reduces mean arterial pressure, and mitigates the progression of cardiac hypertrophy. GSK2181236A is applicable in research focused on cardiovascular diseases, including hypertension and related pathologies.

Cat. No.

A60890

CAS No.

145257-03-0

Guanylin (mouse, rat)

Guanylin (mouse, rat) is a 15-amino acid peptide that functions as an activator of intestinal guanylate cyclase. This compound plays a crucial role in regulating electrolyte and fluid balance in the intestine. Guanylin is commonly used in research related to diarrheal diseases and gastrointestinal disorders, providing insights into mechanisms of fluid secretion and absorption.

Cat. No.

A60895

CAS No.

538368-27-3

A-350619

A-350619 is a selective activator of soluble guanylate cyclase (sGC), resulting in elevated intracellular levels of cyclic guanosine monophosphate (cGMP). This compound has been demonstrated to significantly induce penile erection, highlighting its potential therapeutic applications in erectile dysfunction research. Further studies may explore its effects on vascular smooth muscle relaxation and other cGMP-related biological processes.

Cat. No.

A60896

CAS No.

1217201-17-6

A-350619 hydrochloride

A-350619 hydrochloride is a soluble guanylate cyclase (sGC) activator that enhances intracellular cGMP levels. This compound exhibits significant biological activity in the modulation of vasodilation and neurotransmission, making it relevant for research into erectile dysfunction and related vascular disorders. Its role in enhancing sGC activity makes it a valuable tool for investigating therapeutic strategies targeting nitric oxide signaling pathways.