Cytochrome P450

Cat. No.

A69988

CAS No.

2428734-45-4

CYP4Z1-IN-2

CYP4Z1-IN-2 is a reversible inhibitor of the enzyme CYP4Z1, displaying a Ki value of 2.2 μM. This compound effectively reduces the production of 14,15-EET in breast cancer cells and demonstrates an IC50 of 5.9 μM in inhibiting the CYP4Z1-mediated Luc-BE O-debenzylation reaction. CYP4Z1-IN-2 serves as a valuable tool for research focused on the role of CYP4Z1 in cancer biology and associated signaling pathways.

Cat. No.

A69993

CAS No.

2244569-14-8

DLCI-1

DLCI-1 is a selective oral inhibitor of cytochrome P450 2A6 (CYP2A6), demonstrating potent activity in modulating nicotine metabolism. This compound has been shown to significantly reduce nicotine self-administration in both male and female murine models, making it a valuable tool for research into nicotine addiction and metabolism. Its specificity towards CYP2A6 supports investigations into the therapeutic implications of targeting this enzyme in drug development and addiction studies.

Cat. No.

A69994

CAS No.

99957-90-1

Org30958

Org30958 is a potent inhibitor of cytochrome P450 enzymes, specifically targeting aromatase. This compound demonstrates significant biological activity in vivo, making it a valuable tool for researchers studying estrogen biosynthesis and related pathways. Its application extends to investigations of hormone-dependent cancers and metabolic disorders linked to altered P450 activity.

Cat. No.

A76652

CAS No.

1315449-72-9

Osilodrostat phosphate

Synonyms: LCI699 phosphate

Osilodrostat phosphate is a selective inhibitor of 11β-hydroxylase (CYP11B1) and aldosterone synthase (CYP11B2), demonstrating an IC50 of 35 nM and 0.7 nM, respectively, for human enzymes. This compound effectively inhibits the synthesis of aldosterone and corticosterone, contributing to its role in blood pressure regulation. Osilodrostat phosphate is particularly valuable for research investigating Cushing syndrome and related disorders involving dysregulated steroidogenesis.

Cat. No.

A78549

CAS No.

86831-54-1

Rhodiosin

Rhodiosin is a dual inhibitor of CYP2D6 and acetylcholinesterase (AChE), extracted from the root of Rhodiola rosea. It exhibits an IC50 value of 0.761 μM for CYP2D6 and a Ki of 0.769 μM. This compound demonstrates notable antioxidant and neuroprotective properties, contributing to the regulation of the HIF-1α signaling pathway, which is vital for central nervous system protection. Rhodiosin serves as a valuable tool for research in neuropharmacology and metabolic studies.

Cat. No.

B21899

CAS No.

69097-98-9

(±)Homoeriodictyol (racemic)

(±) Homoeriodictyol is a potent inhibitor of aromatase (CYP19), an enzyme critical in estrogen biosynthesis. This compound is primarily utilized in breast cancer research to investigate estrogen-mediated pathways and their role in tumor growth. Its inhibitory activity makes it a valuable tool for studying therapeutic strategies targeting aromatase in hormone-related cancers.