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Bioluminescence: Luciferins & Luciferase
This category includes luciferin substrates, luciferase enzymes and luciferase modulators for laboratory research. The selection covers D-luciferin and its salts, luciferin analogs, coelenterazine and its derivatives, firefly and bacterial luciferases, and luciferase inhibitors and an activator. These products are listed for bioluminescence and reporter-assay research. Check each product record for its intended enzyme system, substrate requirements and supporting references.
Firefly luciferase-IN-4 is a potent inhibitor of ATP-dependent luciferase, specifically targeting firefly luciferase activity. With a nanomolar inhibitory potency (pIC50 = 6.5), this compound serves as a valuable tool for studying luciferase-mediated bioluminescence in various biological systems. Its applications include elucidating signaling pathways and enhancing the understanding of gene expression assays utilizing luciferase as a reporter.
D-Luciferin phosphate trisodium is a bioluminescent substrate specifically designed for firefly luciferase. Upon dephosphorylation by alkaline phosphatase, it releases the fluorescent compound D-fluorescein, enabling highly sensitive detection of phosphatase activity. This reagent is widely utilized in biochemical assays and molecular biology research to study enzyme kinetics and substrate interactions.
L-Luciferin is an alternative substrate for the enzyme luciferase, primarily utilized for bioluminescence applications in research. It competes with firefly luciferin, influencing light production based on enzyme concentration and substrate availability. This compound is widely used in studies involving gene expression, cellular activity, and drug screening, providing valuable insights into various biological processes.
