ROR

Cat. No.

A77593

CAS No.

2247083-47-0

RORγt modulator 2

RORγt modulator 2 is a selective modulator of retinoid-related orphan receptor γt (RORγt), exhibiting an IC50 of less than 50 nM. This compound is valuable for investigating RORγt-mediated pathologies including pain, inflammation, chronic obstructive pulmonary disease (COPD), asthma, rheumatoid arthritis, colitis, multiple sclerosis, psoriasis, neurodegenerative disorders, and cancer. Research on RORγt modulator 2 can contribute to understanding therapeutic approaches targeting these conditions.

Cat. No.

A77594

CAS No.

2741870-21-1

RORγt inverse agonist 28

RORγt inverse agonist 28 is a potent inverse agonist targeting the retinoic acid receptor-related orphan receptor gamma t (RORγt). It effectively regulates the differentiation of T helper 17 (Th17) cells and inhibits interleukin-17 (IL-17) production. This compound is valuable for research into inflammation and autoimmune diseases, providing insights into potential therapeutic approaches.

Cat. No.

A77595

CAS No.

2188177-73-1

RORγt modulator 4

RORγt modulator 4 is an effective modulator of the RORγt pathway. It has been shown to influence IL-17A production in cells derived from mouse spleen, thereby contributing to research in autoimmune diseases and inflammation. This compound is valuable for studies aimed at understanding the role of RORγt in T cell differentiation and related biological processes.

Cat. No.

A77596

CAS No.

1242610-59-8

RORγ inverse agonist 2

RORγ inverse agonist 2 is a potent inverse agonist targeting the retinoic acid receptor-related orphan receptor RORγ, exhibiting IC50 values of 0.4 μM and 0.9 μM for Gal4-RORγ and full-length RORγ, respectively. This compound is significant for research applications focused on autoimmune diseases, providing insights into RORγ's role in immune regulation and pathology.

Cat. No.

A77597

CAS No.

1599531-55-1

JNJ-54119936

JNJ-54119936 is an inverse agonist of the retinoic acid receptor-related orphan receptor gamma (RORγ) with a Kd of 5.3 nM. This compound exhibits significant modulation of RORγ activity, making it valuable for research into autoimmune diseases and inflammatory responses. Its specific targeting of RORγ allows for the exploration of downstream signaling pathways and therapeutic applications in related biological processes.

Cat. No.

A77598

CAS No.

2230877-38-8

RORγt modulator 3

RORγt Modulator 3 is a selective modulator of the retinoic acid receptor-related orphan receptor gamma t (RORγt). This compound exhibits significant biological activity in the modulation of immune responses, making it valuable for research into RORγt-mediated diseases, including pain, inflammation, chronic obstructive pulmonary disease (COPD), asthma, rheumatoid arthritis, colitis, multiple sclerosis, psoriasis, neurodegenerative disorders, and various cancer types. Its application may facilitate the development of novel therapeutic strategies targeting RORγt pathways.

Cat. No.

A77599

CAS No.

1426803-07-7

RORγt inhibitor 4

RORγt Inhibitor 4 is a potent inhibitor of the RORγt transcription factor, specifically designed for oral administration and capable of penetrating the central nervous system. This compound demonstrates significant efficacy in modulating immune responses, making it valuable for research into autoimmune conditions, particularly in the context of experimental autoimmune encephalomyelitis. Its ability to selectively inhibit RORγt activity positions it as a promising tool for investigating therapeutic strategies in autoimmune diseases.

Cat. No.

A77600

CAS No.

2425563-60-4

TF-S14

TF-S14 is a reverse agonist of RORγt, a transcription factor critically involved in Th17 cell differentiation and cytokine production. By binding to RORγt, TF-S14 effectively inhibits the secretion of pro-inflammatory cytokines such as IL-17A, IL-21, and IL-22. This compound is valuable for research applications focused on autoimmune diseases and transplantation rejection mechanisms.

Cat. No.

A77601

CAS No.

2247604-77-7

RORγt inverse agonist 34

RORγt inverse agonist 34 is a selective inverse agonist of the retinoic acid receptor-related orphan receptor gamma t (RORγt), exhibiting an IC50 of 0.094 μM for the RORγt-LBD. This compound demonstrates significant biological activity in modulating RORγt signaling pathways, making it a valuable tool for research into psoriasis and related inflammatory conditions. Its use facilitates the exploration of therapeutic strategies targeting RORγt in the regulation of immune responses.

Cat. No.

A77602

CAS No.

2241769-59-3

RORγt agonist 4

RORγt Agonist 4 is a potent and selective agonist of the retinoic acid receptor-related orphan receptor gamma t (RORγt). This compound enhances metabolic stability and demonstrates significant biological activity in preclinical models. Notably, RORγt Agonist 4 has shown therapeutic potential in tumor models, including mouse B16F10 melanoma and LLC lung adenocarcinoma, making it a valuable tool for investigating RORγt-mediated pathways in cancer research.

Cat. No.

A77603

CAS No.

2301159-96-4

RORγt inverse agonist 32

RORγt Inverse Agonist 32 is an orally active compound that targets the RORγt receptor as an inverse agonist. It plays a critical role in modulating inflammatory pathways and is valuable for research into immune responses and related diseases. This compound is particularly useful for studies focusing on the regulation of Th17 cell differentiation and the development of autoimmune conditions.

Cat. No.

A77604

CAS No.

2673278-10-7

RORγt inhibitor 2

RORγt Inhibitor 2 is a selective inhibitor of the RORγt transcription factor, exhibiting an IC50 value of 9.2 nM. This compound demonstrates significant anti-inflammatory and immunomodulatory activity, making it a valuable tool for research into cancer, autoimmune disorders, and inflammatory conditions driven by RORγt signaling. Its specificity and potency enable detailed studies of RORγt's biological roles and therapeutic potential.

Cat. No.

A77605

CAS No.

3092129-97-7

Gala-SR

Synonyms: Gala-SR1078

Gala-SR (Gala-SR1078) is a selective RORα agonist that enhances the amplitude of circadian rhythms, making it a valuable tool for the investigation of disorders related to circadian regulation. This compound has potential applications in studying rhythm disturbances and can provide insights into the role of circadian mechanisms in periodontitis research. Its ability to modulate rhythmic activity positions it as a significant reagent in the exploration of chronobiology and its implications for human health.

Cat. No.

A77606

CAS No.

1952239-59-6

CD12681

CD12681 is a selective inverse agonist of RORγ, exhibiting IC50 values of 19 nM and 10 nM against RORγ GAL4 and CD4-IL-17 cells, respectively. This compound effectively reduces IL-17-mediated inflammatory cell recruitment, making it a valuable tool for studying inflammatory pathways. CD12681 shows promise for research applications in conditions such as psoriasis, facilitating the exploration of novel therapeutic strategies.

Cat. No.

A77607

CAS No.

2309312-90-9

SR1555 hydrochloride

SR1555 hydrochloride is a selective inverse agonist of the retinoic acid receptor-related orphan nuclear receptor γ (RORγ), exhibiting an IC50 of 1 μM. This compound effectively inhibits the development and function of pro-inflammatory TH17 cells while promoting an increase in anti-inflammatory T regulatory (Treg) cells. SR1555 hydrochloride is primarily utilized in research targeting autoimmune diseases, providing insights into potential therapeutic strategies for immune modulation.

Cat. No.

A77608

CAS No.

2088333-58-6

RORγ-IN-2

RORγ-IN-2 is a selective inhibitor of RAR-related orphan receptor gamma (RORγ) with a Ki of 16.6 nM for human RORγ. This compound is primarily utilized in research focused on IL-17-dependent autoimmune diseases, providing insights into the modulation of immune responses and inflammation. RORγ-IN-2 serves as a valuable tool for investigating the therapeutic potential of targeting RORγ in various pathological conditions.

Cat. No.

A77609

CAS No.

1599530-54-7

RORγt inverse agonist 36

RORγt inverse agonist 36 is a selective inverse agonist targeting the retinoid-related orphan receptor gamma t (RORγt). This compound modulates RORγt activity, leading to inhibition of Th17 cell differentiation and cytokine production. It is primarily utilized in research focused on inflammation and immunology, offering valuable insights into therapeutic approaches for autoimmune diseases.

Cat. No.

A77610

CAS No.

1445901-41-6

RORγt inverse agonist 30

RORγt Inverse Agonist 30 is a selective inverse agonist of the RORγt nuclear receptor, exhibiting an IC50 of 46 nM. This compound effectively modulates RORγt activity, making it a valuable tool in the study of autoimmune disorders. Its ability to inhibit RORγt function positions it as a promising candidate for research into therapeutic strategies for conditions such as multiple sclerosis and other inflammatory diseases.

Cat. No.

A77611

CAS No.

919974-50-8

RORC modulator-1

RORC modulator-1 is a selective modulator of the retinoic acid receptor-related orphan receptor C (RORC). It demonstrates the ability to regulate RORC activity, impacting the expression of genes involved in immune response and inflammation. This compound is valuable for research applications focused on T helper cell differentiation, autoimmune diseases, and the study of related signaling pathways.

Cat. No.

A77612

CAS No.

1164457-99-1

CID 7309015

CID 7309015 is a selective inhibitor of retinoic acid-related orphan receptor gamma (ROR-γ). This compound demonstrates significant potential in modulating inflammatory pathways, particularly in the context of NF-κB signaling and inflammatory arthritis research. CID 7309015 serves as a valuable tool for investigating the roles of ROR-γ in immune response and inflammatory diseases.

Cat. No.

A77613

CAS No.

1361413-10-6

RORγt inhibitor 3

RORγt inhibitor 3 is a potent and orally active inhibitor of retinoic acid receptor-related orphan receptor-gamma-t (RORγt), which plays a crucial role in Th17 cell differentiation. This compound demonstrates high binding affinity and effectively modulates immune responses, making it particularly relevant for research in autoimmune disorders. Its efficacy has been validated in mouse models of experimental autoimmune encephalomyelitis (EAE) and collagen-induced arthritis (CIA), highlighting its potential for therapeutic applications in inflammatory diseases.

Cat. No.

A77614

CAS No.

2055538-47-9

Cintirorgon sodium

Synonyms: LYC-55716 sodium

Cintirorgon sodium is a selective and orally bioavailable RORγ agonist that modulates gene expression in RORγ-expressing T lymphocytes. This compound enhances effector functions and reduces immunosuppressive mechanisms, contributing to decreased tumor growth and improved survival rates in various preclinical models. Cintirorgon sodium is a valuable tool for research applications focused on immunotherapy and cancer biology.