MMP

Cat. No.

A76813

CAS No.

1333379-23-9

ND-322 hydrochloride

ND-322 hydrochloride is a potent and selective inhibitor of matrix metalloproteinases (MMPs), specifically targeting gelatinase activity. This compound demonstrates significant biological activity in reducing melanoma tumor growth and effectively delaying metastatic dissemination. ND-322 hydrochloride serves as a valuable tool in cancer research, particularly in studies focused on tumor invasion and metastasis.

Cat. No.

A76815

CAS No.

897799-81-4

MMP2-IN-3

MMP2-IN-3 is a potent inhibitor of matrix metalloproteinase-2 (MMP-2) with an IC50 of 31 μM. This compound also demonstrates inhibitory effects on MMP-9 and MMP-8, presenting IC50 values of 26.6 μM and 32 μM, respectively. MMP2-IN-3 is valuable for research involving extracellular matrix remodeling, inflammation, and cancer progression, making it an important tool for studies focused on metalloproteinase activity modulation.

Cat. No.

A76817

CAS No.

95311-94-7

Lucideric acid A

Lucideric acid A is a natural MMP inhibitor derived from Ganoderma lucidum. It effectively inhibits PMA-induced MMP-9 activity, demonstrating significant anti-invasive effects on hepatoma cells. This compound is useful for research applications focused on cancer metastasis and matrix remodeling.

Cat. No.

A76819

CAS No.

869577-51-5

MMP-2 Inhibitor II

MMP-2 Inhibitor II is a selective inhibitor targeting matrix metalloproteinase-2 (MMP-2). It displays significant inhibitory activity with a potency of 2.4 μM against MMP-2, while exhibiting lower affinity for MMP-1 and MMP-7, at 45 μM and 379 μM, respectively. This compound is valuable for research into the regulation of extracellular matrix remodeling, and its role in various pathological conditions, including cancer metastasis and tissue fibrosis.

Cat. No.

A76821

CAS No.

208663-26-7

MMP12-IN-3

MMP12-IN-3 is a potent inhibitor of matrix metalloproteinase 12 (MMP12), exhibiting an IC50 value of 4.9 nM. This compound is relevant for research into chronic respiratory diseases, particularly emphysema, due to its role in modulating extracellular matrix remodeling and inflammation. Its specificity and efficacy make it a valuable tool for exploring therapeutic strategies targeting MMP12 in pulmonary pathologies.

Cat. No.

A76822

CAS No.

193022-38-7

RS-104966

RS-104966 is a potent inhibitor of matrix metalloproteinase-1 (MMP-1), a key enzyme involved in collagen degradation. It functions by inducing a conformational change in the side chains of the S10 pocket of MMP-1, thereby inhibiting its enzymatic activity. This compound is valuable for studies related to tissue remodeling, inflammation, and various pathological conditions where MMP-1 plays a critical role. Its application extends to research in cancer metastasis, wound healing, and fibrosis.

Cat. No.

A76823

CAS No.

777075-44-2

cis-ACCP

cis-ACCP is a selective inhibitor targeting matrix metalloproteinase-2 (MMP-2), demonstrating potent activity in inhibiting MMP-2 and MMP-9 with IC50 values of 4 μM and 20 μM, respectively. This compound serves as a valuable tool in cancer research, particularly in studies related to antimetastatic therapies and the modulation of extracellular matrix dynamics. cis-ACCP is suitable for investigating the mechanisms underlying various chronic diseases linked to MMP activity.

Cat. No.

A76825

CAS No.

2389060-50-6

Linvemastat

Synonyms: FP-020

Linvemastat is a potent inhibitor of matrix metalloproteinase-12 (MMP-12) with an IC50 value of less than 10 nM, demonstrating high selectivity over MMP-1, -2, -3, -7, -9, -10, and -14. This compound effectively reduces lung fibrosis in a bleomycin-induced unilateral lung fibrosis model and diminishes kidney damage, interstitial inflammation, and fibrosis in a unilateral ureteral occlusion model. Linvemastat is valuable for research into inflammatory diseases, including idiopathic pulmonary fibrosis (IPF), inflammatory bowel disease (IBD), and asthma.

Cat. No.

A76826

CAS No.

95311-96-9

Lucidenic acid C

Lucidenic acid C is a natural compound derived from Ganoderma lucidum, functioning as an inhibitor of matrix metalloproteinases (MMPs). It specifically inhibits PMA-induced MMP-9 activity, demonstrating anti-invasive properties against hepatoma cells. This makes Lucidenic acid C a valuable reagent for research focused on cancer biology and cell invasion mechanisms.

Cat. No.

A76827

CAS No.

459814-89-2

AZD-1236

AZD-1236 is a potent and reversible inhibitor targeting human matrix metalloproteinases MMP-9 and MMP-12. It exhibits significant biological activity in modulating extracellular matrix remodeling and has potential applications in cancer research, inflammatory disorders, and tissue repair studies. This compound serves as a valuable tool for elucidating the role of MMPs in various pathological conditions.

Cat. No.

A76828

CAS No.

226395-93-3

SD-2590 hydrochloride

SD-2590 hydrochloride is a highly potent inhibitor of matrix metalloproteinases (MMPs), exhibiting IC50 values of less than 0.1 nM for MMP2 and MMP13, 0.18 nM for MMP9, and 1.7 nM for MMP8. This compound effectively inhibits the dilation of the left ventricle in rat models, demonstrating its potential for cardiovascular research applications. The selective inhibition of MMPs by SD-2590 can provide valuable insights into various pathological processes, including tissue remodeling and inflammation.

Cat. No.

A76829

CAS No.

2241964-36-1

MMP-9-IN-6

MMP-9-IN-6 is a selective MMP-9 inhibitor with an IC50 value of 50 μM, demonstrating significant potential in modulating matrix metalloproteinase activity. This compound exhibits promising anti-ulcer effects, making it a valuable tool for research into inflammatory diseases and tissue remodeling processes. Its ability to selectively inhibit MMP-9 may contribute to the understanding of its role in various pathophysiological conditions.

Cat. No.

A76831

CAS No.

291533-11-4

PG 116800

Synonyms: PG 530742; PGE 530742; PGE 7113313

PG 116800 is an orally active inhibitor of matrix metalloproteinases (MMPs), exhibiting a high affinity for MMP-2, -3, -8, -9, -13, and -14, while showing significantly lower affinity for MMP-1 and -7. This compound demonstrates notable biological activity in modulating enzymatic processes involved in extracellular matrix degradation. PG 116800 is primarily utilized in research applications related to knee osteoarthritis, providing insights into potential therapeutic strategies for joint-related pathologies.

Cat. No.

A76833

CAS No.

102067-92-5

Epitheaflagallin 3-O-gallate

Epitheaflagallin 3-O-gallate is a selective matrix metalloproteinase (MMP) inhibitor. This minor polyphenol, found in black tea, exhibits significant anti-inflammatory and antioxidative properties. It effectively inhibits pancreatic lipase and Streptococcus sorbinus glycosyltransferase, while also reducing the activity and synthesis of MMP-1 and MMP-3 in human gingival fibroblasts. These biological activities make it a valuable tool for research in inflammation and tissue remodeling studies.

Cat. No.

A76836

CAS No.

2865102-08-3

TP0628103

TP0628103 is a potent selective inhibitor of matrix metalloproteinase-7 (MMP-7), demonstrating an IC50 value of 0.17 nM. MMP-7 is implicated in various pathological processes, including cancer progression and fibrosis. This compound is valuable for research applications focusing on the modulation of MMP-7 activity in cancer and fibrotic diseases.

Cat. No.

A76837

CAS No.

2490543-89-8

MMP-9-IN-8

MMP-9-IN-8 is a selective matrix metalloproteinase-9 (MMP-9) inhibitor that exhibits inhibitory activities of 42.16% and 58.28% at concentrations of 10 μM and 50 μM, respectively. This compound demonstrates notable anti-cancer properties, effectively inducing apoptosis in MCF-7 breast cancer cells, with an IC50 value of 23.42 μM. MMP-9-IN-8 is suitable for research applications involving cancer biology and therapeutic development targeting tumor progression and metastasis.

Cat. No.

A76839

CAS No.

2252493-33-5

(R)-ND-336

(R)-ND-336 is a selective inhibitor of matrix metalloproteinase-9 (MMP-9), exhibiting a Ki value of 19 nM. It also demonstrates inhibitory activity against MMP-2 (Ki=127 nM) and MMP-14 (Ki=119 nM). This compound is useful for investigating therapeutic approaches in conditions such as diabetic foot ulcers (DFUs) and plays a critical role in studies related to tissue remodeling and wound healing.

Cat. No.

A76840

CAS No.

92535-43-8

MMP2-IN-4

MMP2-IN-4 is a selective inhibitor targeting matrix metalloproteinase 2 (MMP2). It demonstrates potent inhibition of MMP2, MMP9, and MMP12, exhibiting IC50 values of 266.74 nM, 402.75 nM, and 1237.39 nM, respectively. This compound is valuable for research applications focused on understanding the role of MMPs in various pathological conditions, including cancer metastasis and tissue remodeling.

Cat. No.

A76841

CAS No.

161314-70-1

CGS 27023A free base

CGS 27023A free base is a potent, non-peptidic inhibitor of matrix metalloproteinases (MMPs), demonstrating Ki values of 43 nM for MMP-3, 33 nM for MMP-1, 20 nM for MMP-2, and 8 nM for MMP-9. This compound effectively inhibits cartilage degradation in a stromelysin-induced rabbit model, making it a valuable tool for studying the pathogenesis of arthritis and potential therapeutic interventions. Its selective inhibition of MMPs underscores its relevance in research focused on inflammatory and degenerative joint diseases.

Cat. No.

A76843

CAS No.

869298-22-6

T 26c sodium

T26c sodium is a highly potent and selective inhibitor of MMP-13, exhibiting an IC50 value of 6.9 pM. This compound effectively prevents the degradation of bovine nasal septal cartilage explants, making it a valuable tool for research into cartilage metabolism and tissue preservation. T26c sodium is particularly useful in studies related to arthritis and other degenerative joint diseases where MMP-13 plays a critical role in extracellular matrix remodeling.

Cat. No.

A76844

CAS No.

230954-09-3

CP-544439

CP-544439 is a potent inhibitor of matrix metalloproteinase-13 (MMP-13) with an IC50 of 0.75 nM. This compound effectively modulates extracellular matrix remodeling and has potential applications in the study of various diseases characterized by tissue degradation and inflammation. Its oral bioactivity makes CP-544439 a valuable tool for researchers investigating the role of MMP-13 in pathological conditions.

Cat. No.

A76845

CAS No.

766536-21-4

PF-00356231

PF-00356231 is a selective inhibitor of matrix metalloproteinase MMP-12, exhibiting an IC50 value of 1.4 μM. This non-peptidic compound forms a stable complex with MMP-12 and further demonstrates activity against MMP-13, MMP-8, MMP-9, and MMP-3 with IC50 values of 0.00065, 1.7, 0.98, and 0.39 μM, respectively. PF-00356231 is valuable for research into inflammation, tissue remodeling, and various diseases involving aberrant matrix metalloproteinase activity.

Cat. No.

A76846

CAS No.

226072-63-5

Solimastat

Synonyms: BB-3644

Solimastat is a potent metalloproteinase (MMP) inhibitor that effectively blocks both constitutive and antibody-stimulated shedding of CD30 from cell surfaces, exhibiting an IC50 of 180 nM. This compound enhances the persistence of the anti-CD30 antibody Ki-3 on targeted cells and promotes its internalization. Additionally, Solimastat increases the cytotoxicity of Ki-3.dgA towards CD30+ L540 cells. It serves as a valuable reagent for research focused on CD30+ malignancies.

Cat. No.

A76849

CAS No.

169799-04-6

CGS 27023A

CGS 27023A is a non-peptidic, orally active inhibitor of matrix metalloproteinases (MMPs), exhibiting Ki values of 43 nM for MMP-3, 33 nM for MMP-1, 20 nM for MMP-2, and 8 nM for MMP-9. This compound effectively prevents cartilage degradation in a stromelysin-induced rabbit cartilage model. CGS 27023A is suitable for studying diseases such as arthritis and exploring the role of MMPs in various pathological conditions.

Cat. No.

A76852

CAS No.

1816257-74-5

BAY-7598

BAY-7598 is a selective inhibitor of matrix metalloproteinase 12 (MMP12), demonstrating potent activity with IC50 values of 0.085 nM for human MMP12, 0.67 nM for murine MMP12, and 1.1 nM for rat MMP12. This orally bioavailable compound is valuable for research applications involving chronic inflammatory diseases, where MMP12 plays a critical role in tissue remodeling and inflammation. Its specificity for MMP12 allows for targeted studies in the mechanistic understanding of these conditions.