PARP

Inhibitory Selectivity
Catalog No.Inhibitor Name PARPPARP1PARP2PARP3V-PARPTankyrase-1
A10111Olaparib
***
****
*
A10026Veliparib
***
***
A14182Rucaparib
****
A11243Talazoparib
****
A10046AG-14361
***
A10475INO-1001
**
A10019A-966492
****
****
A15215PJ34
***
A12665PJ34 HCl
***
A11026Niraparib
***
****
*
**
**
A12750UPF 1069
*
**
A14309ME0328
*
**
A14371Benzamide
*
A15375NU1025
**
A10164Iniparib
A12393AZD2461
A16344BGP-15
A10045AG-014699 (Rucaparib)
****
A153704-HQN
*
A15371BYK 204165
*
*
A15372BYK 49187
*
*
A15374EB 47
**
A15373DR 2313
*
**

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.



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Catalog No. Product Name Application Product Information
A15373

DR 2313

PARP inhibitor
PARP Inhibitor XIDR 2313, PARP Inhibitor XI, is a water soluble pyrimidinone compound that functions as a PARP (Poly(ADP-ribose) polymerase) inhibitor.
A15370

4-HQN

PARP inhibitor
4-HQN has been shown to inhibit PARP (poly(ADP-ribose) synthetase) which catalyzes covalent attachment of the ADP-ribose moiety of NAD+ to various proteins.
A15371

BYK 204165

PARP-1 inhibitor
BYK204165 is a cell-permeable isoquinolinedione compound that potently and selectively inhibits poly (ADP-ribose) polymerase 1 (PARP1).
A15372

BYK 49187

PARP-1/PARP-2 inhibitor
BYK 49187, PARP-1 and PARP-2 inhibitor (pIC50 values are 8.36 and 7.50 for cell-free recombinant PARP-1 and murine PARP-2 respectively).
A15374

EB 47

PARP1 Inhibitor
EB 47 is a potent inhibitor of PARP1 with IC50 of 45 nM.
A15375

NU 1025

PARP inhibitor
NU 1025 is a potent poly(ADP-ribose) polymerase (PARP) inhibitor, which potentiates the cytotoxicity of a panel of mechanistically diverse anti-cancer agents in L1210 cells.
A15528 SALE

G007-LK

TNKS inhibitor
G007-LK displays high selectivity toward tankyrases 1 and 2 with biochemical IC50 values of 46 nM and 25 nM, respectively, and a cellular IC50 value of 50 nM combined with an excellent pharmacokinetic profile in mice,
A15786

NVP-TNKS656

TNKS2 inhibitor
NVP-TNKS656 is a highly potent, selective, and orally active TNKS2 inhibitor with IC50 of 6 nM; > 300 fold selectivity against PARP1 and PARP2.
A15927

MN-64

TNKS inhibitor
MN-64 is a potent and selective inhibitor of Tankyrase 1 and 2 (IC50 = 6 and 72 nM, respectively).
A15873 SALE

AZ6102

TNKS1/2 inhibitor
AZ6102 is a potent TNKS1/2 inhibitor that has 100-fold selectivity against other PARP family enzymes and shows IC50 of 5 nM for Wnt pathway inhibition in DLD-1 cells.
A13731 SALE

JW 55

TNKS1/2 inhibitor
JW 55 is an inhibitor of the PARP domain of tankyrase 1 and 2 (TNKS1/2).
A15215 SALE

PJ34

PARP inhibitor
PJ34 is a novel potent specific inhibitor of PARP-l/2 with EC50 of 20 nM.
A15024

BMN-673 8R,9S

PARP Inhibitor
BMN-673 (8R,9S) is the (8R,9S) enantiomer of BMN-673. BMN 673 is a novel PARP inhibitor with IC50 of 0.58 nM.
A10026

ABT-888 (Veliparib)

PARP inhibitor
ABT-888(Veliparib) is a potential anti-cancer drug acting as a PARP inhibitor.
A11454

TC-E 5001

TNKS inhibitor
TC-E 5001 is dual tankyrase (TNKS) inhibitor (Kd values are 79 and 28 nM for TNKS1 and TNKS2 respectively, IC50 = 33 nM for TNKS2) that is devoid of activity at PARP1 and PARP2 (IC50 >19 uM). Inhibits Wnt signaling and stabilizes Axin2 levels.
A14986

AIM-100

Ack1 (TNK2) inhibitor
AIM-100 is a small molecule inhibitor of Ack1 with an IC50 of 24 nM.
A14371

Benzamide

PARP-1 inhibitor
Benzamide is the amide derivative of benzoic acid and an inhibitor of poly(ADP-ribose) polymerase-1 (PARP-1).
A14309

ME0328

PARP3 inhibitor
ME0328 is a potent and selective PARP inhibitor with IC50 of 0.89 μM for PARP3, about 7-fold selectivity over PARP1.
A10111 SALE

Olaparib (AZD2281)

PARP inhibitor
Olaparib (AZD2281) is an inhibitor of poly ADP ribose polymerase (PARP), an enzyme involved in DNA repair.
A10164 SALE

BSI-201 (Iniparib)

PARP inhibitor
BSI-201 is a potent inhibitor of PARP-1 and has been shown to cross the blood-brain barrier.
A10045 SALE

AG-014699 (Rucaparib)

PARP inhibitor
AG-014699 (Rucaparib) is a PARP inhibitor that inhibits poly(ADP-ribose) polymerase (PARP) is a key enzyme in DNA repair.
A10046 SALE

AG14361

PARP inhibitor
AG14361 is a potent PARP inhibitor, enhanced Temozolomide (TMZ) cytotoxicity in MMR(mismatch repair)-proficient / deficient cells.
A10475

INO-1001

PARP Inhibitor
INO-1001 is a novel PARP inhibitor, known to sensitize cells to radiation in vitro by inhibiting the repair of DNA damage.
A10019 SALE

A-966492

PARP1 inhibitor
A-966492 displayed high potency against the poly(ADP-ribose) polymerase-1 (PARP-1) enzyme with a K(i) of 1 nM and an EC(50) of 1 nM in a whole cell assay.
A11026 SALE

MK-4827 (Niraparib)

PARP inhibitor
MK-4827 is a novel potent, orally bioavailable PARP-1 and PARP-2 inhibitor.
A11243 SALE

BMN673

PARP inhibitor
BMN-673 is an orally bioavailable inhibitor of the nuclear enzyme poly(ADP-ribose) polymerase (PARP) with potential antineoplastic activity.
A12665 SALE

PJ 34 hydrochloride

PARP inhibitor
PJ 34 hydrochloride is a potent inhibitor of poly(ADP-ribose) polymerase (PARP) (EC50 = 20 nM).
A12750 SALE

UPF 1069

PARP2 inhibitor
UPF 1069 is a selective poly(ADP-ribose) polymerase (PARP) 2 inhibitor (IC50 values are 0.3 and 8.0 μM for PARP-2 and PARP-1 respectively).
A12393 SALE

AZD-2461

PARP Inhibitor
AZD2461 is a novel and potent PARP inhibitor with lower affinity to P-glycoprotein.
A14182 SALE

Rucaparib

PARP-1 inhibitor
Rucaparib is a potent inhibitor of purified full-length human PARP-1 and shows higher inhibition of cellular PARP in LoVo and SW620 cells.
A14283

WIKI4

Tankyrase inhibitor
WIKI4 is a novel Tankyrase inhibitor with IC50 of 15 nM for TNKS2.
A16344

BGP-15

PARP inhibitor
BGP-15 is a PARP inhibitor, that can protect against heart failure and atrial fibrillation in mice.

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