PARP

Inhibitory Selectivity
Catalog No.Inhibitor Name PARPPARP1PARP2PARP3V-PARPTankyrase-1
A10111Olaparib
***
****
*
A10026Veliparib
***
***
A14182Rucaparib
****
A11243Talazoparib
****
A10046AG-14361
***
A10475INO-1001
**
A10019A-966492
****
****
A15215PJ34
***
A12665PJ34 HCl
***
A11026Niraparib
***
****
*
**
**
A12750UPF 1069
*
**
A14309ME0328
*
**
A14371Benzamide
*
A15375NU1025
**
A10164Iniparib
A12393AZD2461
A16344BGP-15
A10045AG-014699 (Rucaparib)
****
A153704-HQN
*
A15371BYK 204165
*
*
A15372BYK 49187
*
*
A15374EB 47
**
A15373DR 2313
*
**

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.



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Catalog No. Product Name Application Product Information
A15370

4-HQN

PARP-1 inhibitor
4-HQN has been shown to inhibit PARP (poly(ADP-ribose) synthetase) which catalyzes covalent attachment of the ADP-ribose moiety of NAD+ to various proteins.
A10019 SALE

A-966492

PARP inhibitor
A-966492 displayed high potency against the poly(ADP-ribose) polymerase-1 (PARP-1) enzyme with a K(i) of 1 nM and an EC(50) of 1 nM in a whole cell assay.
A10026

ABT-888 (Veliparib)

PARP inhibitor
ABT-888(Veliparib) is a potential anti-cancer drug acting as a PARP inhibitor.
A10045 SALE

AG-014699 (Rucaparib)

PARP inhibitor
AG-014699 (Rucaparib) is a PARP inhibitor that inhibits poly(ADP-ribose) polymerase (PARP) is a key enzyme in DNA repair.
A10046 SALE

AG14361

PARP inhibitor
AG14361 is a potent PARP inhibitor, enhanced Temozolomide (TMZ) cytotoxicity in MMR(mismatch repair)-proficient / deficient cells.
A12393 SALE

AZD-2461

PARP Inhibitor
AZD2461 is a novel and potent PARP inhibitor with lower affinity to P-glycoprotein.
A14371

Benzamide

-
Benzamide is the amide derivative of benzoic acid and an inhibitor of poly(ADP-ribose) polymerase-1 (PARP-1).
A16344

BGP-15

-
BGP-15 is a PARP inhibitor, that can protect against heart failure and atrial fibrillation in mice.
A15024

BMN-673 8R,9S

PARP Inhibitor
BMN-673 (8R,9S) is the (8R,9S) enantiomer of BMN-673. BMN 673 is a novel PARP inhibitor with IC50 of 0.58 nM(PARP1).
A11243 SALE

BMN673

-
BMN-673 is an orally bioavailable inhibitor of the nuclear enzyme poly(ADP-ribose) polymerase (PARP) with potential antineoplastic activity.
A10164 SALE

BSI-201 (Iniparib)

PARP inhibitor
BSI-201 is a potent inhibitor of PARP-1 and has been shown to cross the blood-brain barrier.
A15371

BYK 204165

PARP-1 inhibitor
BYK204165 is a cell-permeable isoquinolinedione compound that potently and selectively inhibits poly (ADP-ribose) polymerase 1 (PARP1).
A15372

BYK 49187

PARP-1/PARP-2 inhibitor
BYK 49187, PARP-1 and PARP-2 inhibitor (pIC50 values are 8.36 and 7.50 for cell-free recombinant PARP-1 and murine PARP-2 respectively).
A15373

DR 2313

PARP inhibitor
PARP Inhibitor XIDR 2313, PARP Inhibitor XI, is a water soluble pyrimidinone compound that functions as a PARP (Poly(ADP-ribose) polymerase) inhibitor.
A15374

EB 47

PARP Inhibitor
EB 47 is a potent inhibitor of PARP1 with IC50 of 45 nM.
A10475

INO-1001

PARP Inhibitor
INO-1001 is a novel PARP inhibitor, known to sensitize cells to radiation in vitro by inhibiting the repair of DNA damage.
A14309

ME0328

-
ME0328 is a potent and selective PARP inhibitor with IC50 of 0.89 μM for PARP3, about 7-fold selectivity over PARP1.
A11026 SALE

MK-4827 (Niraparib)

PARP inhibitor
MK-4827 is a novel potent, orally bioavailable PARP-1 and PARP-2 inhibitor.
A15375

NU 1025

PARP inhibitor
NU 1025 is a potent poly(ADP-ribose) polymerase (PARP) inhibitor, which potentiates the cytotoxicity of a panel of mechanistically diverse anti-cancer agents in L1210 cells.
A10111 SALE

Olaparib (AZD2281)

PARP inhibitor
Olaparib (AZD2281) is an inhibitor of poly ADP ribose polymerase (PARP), an enzyme involved in DNA repair.
A12665 SALE

PJ 34 hydrochloride

PARP inhibitor
PJ 34 hydrochloride is a potent inhibitor of poly(ADP-ribose) polymerase (PARP) (EC50 = 20 nM).
A15215 SALE

PJ34

PARP inhibitor
PJ34 is a novel potent specific inhibitor of PARP-l/2 with EC50 of 20 nM.
A14182 SALE

Rucaparib

-
Rucaparib is a potent inhibitor of purified full-length human PARP-1 and shows higher inhibition of cellular PARP in LoVo and SW620 cells.
A12750 SALE

UPF 1069

PARP2 inhibitor
UPF 1069 is a selective poly(ADP-ribose) polymerase (PARP) 2 inhibitor (IC50 values are 0.3 and 8.0 μM for PARP-2 and PARP-1 respectively).

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