PARP



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Catalog No. Product Name Application Product Information
A15370

4-HQN

PARP-1 inhibitor
4-HQN has been shown to inhibit PARP (poly(ADP-ribose) synthetase) which catalyzes covalent attachment of the ADP-ribose moiety of NAD+ to various proteins.
A10019

A-966492

PARP inhibitor
A-966492 displayed high potency against the poly(ADP-ribose) polymerase-1 (PARP-1) enzyme with a K(i) of 1 nM and an EC(50) of 1 nM in a whole cell assay.
A10026

ABT-888 (Veliparib)

PARP inhibitor
ABT-888(Veliparib) is a potential anti-cancer drug acting as a PARP inhibitor.
A10045

AG-014699 (Rucaparib)

PARP inhibitor
AG-014699 (Rucaparib) is a PARP inhibitor that inhibits poly(ADP-ribose) polymerase (PARP) is a key enzyme in DNA repair.
A10046

AG14361

PARP inhibitor
AG14361 is a potent PARP inhibitor, enhanced Temozolomide (TMZ) cytotoxicity in MMR(mismatch repair)-proficient / deficient cells.
A12393

AZD-2461

PARP Inhibitor
AZD2461 is a novel and potent PARP inhibitor with lower affinity to P-glycoprotein.
A15024

BMN-673 8R,9S

PARP Inhibitor
BMN-673 (8R,9S) is the (8R,9S) enantiomer of BMN-673. BMN 673 is a novel PARP inhibitor with IC50 of 0.58 nM(PARP1).
A11243

BMN673

-
BMN-673 is an orally bioavailable inhibitor of the nuclear enzyme poly(ADP-ribose) polymerase (PARP) with potential antineoplastic activity.
A10164

BSI-201 (Iniparib)

PARP inhibitor
BSI-201 is a potent inhibitor of PARP-1 and has been shown to cross the blood-brain barrier.
A15371

BYK 204165

PARP-1 inhibitor
BYK204165 is a cell-permeable isoquinolinedione compound that potently and selectively inhibits poly (ADP-ribose) polymerase 1 (PARP1).
A15372

BYK 49187

PARP-1/PARP-2 inhibitor
BYK 49187, PARP-1 and PARP-2 inhibitor (pIC50 values are 8.36 and 7.50 for cell-free recombinant PARP-1 and murine PARP-2 respectively).
A15373

DR 2313

PARP inhibitor
PARP Inhibitor XIDR 2313, PARP Inhibitor XI, is a water soluble pyrimidinone compound that functions as a PARP (Poly(ADP-ribose) polymerase) inhibitor.
A15374

EB 47

PARP Inhibitor
EB 47 is a potent inhibitor of PARP1 with IC50 of 45 nM.
A10475

INO-1001

PARP Inhibitor
INO-1001 is a novel PARP inhibitor, known to sensitize cells to radiation in vitro by inhibiting the repair of DNA damage.
A11026

MK-4827 (Niraparib)

PARP inhibitor
MK-4827 is a novel potent, orally bioavailable PARP-1 and PARP-2 inhibitor.
A15375

NU 1025

PARP inhibitor
NU 1025 is a potent poly(ADP-ribose) polymerase (PARP) inhibitor, which potentiates the cytotoxicity of a panel of mechanistically diverse anti-cancer agents in L1210 cells.
A10111

Olaparib (AZD2281)

PARP inhibitor
Olaparib (AZD2281) is an inhibitor of poly ADP ribose polymerase (PARP), an enzyme involved in DNA repair.
A12665

PJ 34 hydrochloride

PARP inhibitor
PJ 34 hydrochloride is a potent inhibitor of poly(ADP-ribose) polymerase (PARP) (EC50 = 20 nM).
A10909

Tenofovir Disoproxil Fumarate

nucleotide reverse transcriptase inhibitor
Tenofovir Disoproxil Fumarate is employed as an anti-HIV agend and a reverse transcriptase inhibitor.
A12750

UPF 1069

PARP2 inhibitor
UPF 1069 is a selective poly(ADP-ribose) polymerase (PARP) 2 inhibitor (IC50 values are 0.3 and 8.0 μM for PARP-2 and PARP-1 respectively).

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