Calcium-Sensing Receptor

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  1. NPS-2143 (SB-262470)

    Catalog No. A11140
    CaSR antagonist
    NPS-2143 is a selective Ca2+-sensing receptor antagonist, shown to block increases in cytoplasmic Ca2+ concentrations elicited by human Ca2+ receptors expressed in HEK293 cells with an IC50 of 43 nM. Learn More
  2. CaSR activator
    AMG-073 HCl (Cinacalcet HCl) represents a new class of compounds for the treatment of hyperparathyroidism known as calcimimetics, which reduce parathyroid hormone (PTH) synthesis and secretion by increasing the sensitivity of the parathyroid calcium-sensing receptor (CaR) to extracellular calcium. Learn More
  3. CaSR agonist
    Strontium ranelate is an antiosteoporotic agent which both increases bone formation and reduces bone resorption, resulting in a rebalance of bone turnover in favor of bone formation. This is similar to the effects of choline stabilized orthosilicic acid. Learn More
  4. AMG 073 (Cinacalcet)

    Catalog No. A11314
    CaSR activator
    AMG-073 (Cinacalcet) represents a new class of compounds for the treatment of hyperparathyroidism. Learn More
  5. Evocalcet

    Catalog No. A17003
    CaSR agonist
    Evocalcet is a calcium-sensing receptor agonist. The calcium-sensing receptor (CaSR) is a Class C G-protein coupled receptor which senses extracellular levels of calcium ion. Learn More

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