AMG-073 HCl (Cinacalcet HCl)

Catalog No.: A10219
CaSR activator
AMG-073 HCl (Cinacalcet HCl) represents a new class of compounds for the treatment of hyperparathyroidism known as calcimimetics, which reduce parathyroid hormone (PTH) synthesis and secretion by increasing the sensitivity of the parathyroid calcium-sensing receptor (CaR) to extracellular calcium.
Grouped product items
Product Name Price Stock Qty
AMG-073 HCl 10mg
$40.00
In stock
AMG-073 HCl 50mg
$100.00
In stock
AMG-073 HCl 100mg
$180.00
In stock
AMG-073 HCl 10mM * 1mL in DMSO
$80.00
In stock
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Biological Activity
Discription AMG-073 HCl (Cinacalcet HCl) represents a new class of compounds for the treatment of hyperparathyroidism known as calcimimetics, which reduce parathyroid hormone (PTH) synthesis and secretion by increasing the sensitivity of the parathyroid calcium-sensing receptor (CaR) to extracellular calcium.
Targets
Target Value
Product Information
Catalog Num A10219
Formula C22H23ClF3N
Molecular Weight 393.9
CAS Number 364782-34-3
SMILES C[C@H](C1=CC=CC2=CC=CC=C21)NCCCC3=CC(=CC=C3)C(F)(F)F.Cl
Synonyms Mimpara, Sensipar
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Solubility
In vitro (25°C) DMSO 67 mg/mL (170.1 mM)
Water Insoluble
Ethanol 28 mg/mL (71.09 mM)
In vivo 30% PEG400+0.5% Tween80+5% propylene glycol 28 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Preparing Stock Solutions
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 25.39 mL 126.94 mL 253.87 mL
0.5 mM 5.08 mL 25.39 mL 50.77 mL
1 mM 2.54 mL 12.69 mL 25.39 mL
5 mM 0.51 mL 2.54 mL 5.08 mL
Useful Calculator

This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

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Please check COA/MSDS for correct molecular weight.

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This equation is commonly abbreviated as: C1V1 = C2V2

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