AMG-073 HCl (Cinacalcet HCl)

Catalog No.: A10219

CaSR activator

AMG-073 HCl (Cinacalcet HCl)

AMG-073 HCl (Cinacalcet HCl) Chemical Structure

CAS NO. 364782-34-3

AMG-073 HCl (Cinacalcet HCl) represents a new class of compounds for the treatment of hyperparathyroidism known as calcimimetics, which reduce parathyroid hormone (PTH) synthesis and secretion by increasing the sensitivity of the parathyroid calcium-sensing receptor (CaR) to extracellular calcium.

Availability: In stock

Package Price Qty
10 mg
$40.00
50 mg
$100.00
100 mg
$180.00
10mM * 1mL in DMSO
$80.00
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Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

AMG-073 HCl (Cinacalcet HCl) represents a new class of compounds for the treatment of hyperparathyroidism known as calcimimetics, which reduce parathyroid hormone (PTH) synthesis and secretion by increasing the sensitivity of the parathyroid calcium-sensing receptor (CaR) to extracellular calcium.
Targets
CaSR
2.8 μM
In vitro (25°C) DMSO 67 mg/mL (170.1 mM)
Water Insoluble
Ethanol 28 mg/mL (71.09 mM)
In vivo 30% PEG400+0.5% Tween80+5% propylene glycol 28 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 25.39 mL 126.94 mL 253.87 mL
0.5 mM 5.08 mL 25.39 mL 50.77 mL
1 mM 2.54 mL 12.69 mL 25.39 mL
5 mM 0.51 mL 2.54 mL 5.08 mL

*The above data is based on the productmolecular weight 393.9. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A10219
Actions Activator
CAS No. 364782-34-3
Formula C22H23ClF3N
M. Wt 393.9
Purity >98%
Synonyms Mimpara, Sensipar
SMILES C[[email protected]](C1=CC=CC2=CC=CC=C21)NCCCC3=CC(=CC=C3)C(F)(F)F.Cl
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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