We use analytics and advertising cookies, which you can accept or reject; see our privacy policy.

Current choice:

Cholesterol & Lipoprotein Metabolism

Cholesterol and lipoprotein metabolism compounds target sterol synthesis and lipoprotein handling. Cholesterol is built through the mevalonate pathway, which also yields farnesyl and geranylgeranyl pyrophosphate for protein prenylation. Lapaquistat acetate and L-731120 inhibit squalene synthase, the branch point that commits farnesyl pyrophosphate to sterol synthesis. NE 10790 acts on farnesyl pyrophosphate synthase (FPPS), while hGGPPS-IN-1 blocks human geranylgeranyl pyrophosphate synthase. Intracellular sterol transport is addressed by Y18501, an inhibitor of oxysterol-binding protein (OSBP). Pelacarsen sodium is an antisense oligonucleotide directed against apolipoprotein(a), the protein that distinguishes lipoprotein(a) from low-density lipoprotein particles.

Items 51-55 of 55

  • OSBP-IN-1
    Cat. No.
    B19808
    CAS No.
    2890760-43-5

    OSBP-IN-1

    OSBP-IN-1 is an oxysterol-binding protein (OSBP) inhibitor that serves as a valuable tool in cancer research. This compound demonstrates significant antitumor activity, making it relevant for studies aimed at understanding OSBP's role in tumor biology and potential therapeutic interventions. Researchers can utilize OSBP-IN-1 to investigate the mechanistic pathways involved in cancer progression and to explore new treatment strategies targeting OSBP-related pathways.

    View Details

    Out of stock

    All 3 sizes
  • BPH-742
    Cat. No.
    B20436
    CAS No.
    1059677-12-1

    BPH-742

    BPH-742 is an inhibitor of geranylgeranyl diphosphate synthase (GGPPS) with an IC50 of 0.1 μM. This compound demonstrates significant antitumor activity, making it a valuable tool for cancer research. BPH-742 can be used to study the biochemical pathways involved in tumor progression and to explore the therapeutic potential of targeting GGPPS in various cancer models.

    View Details

    Out of stock

    All 3 sizes
  • Lanopylin B1
    Cat. No.
    B20716
    CAS No.
    608135-02-0

    Lanopylin B1

    Lanopylin B1 is a selective inhibitor of lanosterol synthase (EC 5.4.99.7), with an IC50 value of 33 μM. This compound plays a significant role in the study of sterol biosynthesis and has potential applications in investigating cholesterol metabolism and related pathways in various biological contexts. Its ability to hinder lanosterol synthesis makes it a useful tool for exploring the mechanisms of lipid regulation and associated diseases.

    View Details

    Out of stock

    All 3 sizes
  • Lanopylin B2
    Cat. No.
    B21179
    CAS No.
    679411-86-0

    Lanopylin B2

    Lanopylin B2 is an inhibitor of lanosterol synthase (EC 5.4.99.7), demonstrating effective inhibition with an IC50 of 41 μM. This compound serves as a valuable tool for research into cholesterol biosynthesis and related metabolic pathways. Its ability to selectively target lanosterol synthase positions it for use in studies investigating the role of sterols in cellular processes and potential therapeutic applications.

    View Details

    Out of stock

    All 3 sizes
  • Lanopylin A1
    Cat. No.
    B21218
    CAS No.
    608135-01-9

    Lanopylin A1

    Lanopylin A1 is a selective inhibitor of lanosterol synthase (EC 5.4.99.7), a key enzyme in the sterol biosynthesis pathway. It exhibits an IC50 of 15 μM, demonstrating significant potency in modulating this target. This compound is useful for investigating the role of lanosterol synthase in cholesterol biosynthesis and related metabolic processes, making it valuable in studies of sterol metabolism and potential therapeutic interventions.

    View Details

    Out of stock

    All 3 sizes

Items 51-55 of 55

Added to your cart

View Cart Checkout

    Loading...