Cholesterol & Lipoprotein Metabolism

Cat. No.

A75851

CAS No.

152755-31-2

LY 295427

Synonyms: Agisterol

LY 295427 is an LDL receptor modulator that acts as a hypocholesterolemic agent by promoting the transcription of the LDL receptor (LDLR). This compound is of particular interest in studies focused on hypercholesterolemia, as it helps to regulate lipid metabolism and lower cholesterol levels. Researchers can utilize LY 295427 to explore its potential therapeutic applications in managing cholesterol-related disorders.

Cat. No.

A75855

CAS No.

180908-67-2

LDL-IN-3

LDL-IN-3 is a highly selective inhibitor of the low-density lipoprotein receptor (LDLR). This compound demonstrates anti-atherosclerotic properties, making it a valuable tool for studying lipid metabolism and cardiovascular disease. Its application spans research into lipid-related disorders and the development of therapeutic strategies for atherosclerosis.

Cat. No.

A76535

CAS No.

251917-79-0

BLT-4

BLT-4 is a selective, reversible inhibitor of scavenger receptor class B type I (SR-BI). It effectively blocks the lipid transfer between high-density lipoproteins (HDL) and cells that is facilitated by SR-BI. This compound is valuable for research applications focused on cholesterol metabolism and cardiovascular disease, offering insights into the role of SR-BI in lipid homeostasis and atherosclerosis.

Cat. No.

A76984

CAS No.

2890760-73-1

OSBP ligand-1

OSBP ligand-1 is a selective inhibitor of oxysterol-binding protein (OSBP) that plays a crucial role in lipid metabolism and cellular signaling. This compound is essential for the synthesis of PROTAC OSBP Degrader-1, facilitating targeted protein degradation studies. Its inhibitory effects on OSBP make it a valuable tool for investigating the biological functions of oxysterols and their implications in various diseases.

Cat. No.

A98551

CAS No.

51527-19-6

FPPS ligand 3

FPPS Ligand 3 is a potent farnesyl pyrophosphate synthase (FPPS) ligand that interacts with the hydrophobic base region of the FPPS binding pocket. This compound is instrumental in the design and synthesis of novel FPPS inhibitors, offering valuable insights for research in metabolic disorders, cancer biology, and related therapeutic areas. Its precise targeting of FPPS makes it a crucial tool for studies aiming to modulate isoprenoid biosynthesis pathways.

Cat. No.

A98900

CAS No.

190595-65-4

Cholesterol absorption inhibitor 1

Cholesterol Absorption Inhibitor 1 is a compound that impedes the intestinal absorption of cholesterol, thereby decreasing the levels of cholesteryl esters in the liver. This compound plays a critical role in studying cholesterol metabolism and its implications in cardiovascular diseases. Its application in research facilitates the understanding of lipid metabolism and potential therapeutic approaches to hypercholesterolemia.

Cat. No.

B18743

CAS No.

1059677-40-5

BPH-628

BPH-628 is a potent inhibitor of geranylgeranyl diphosphate synthase (GGPPS), exhibiting a pIC50 of 6.1. This compound effectively disrupts the biosynthetic pathway of isoprenoids by targeting GGPPS, making it a valuable tool for research into cancer, cardiovascular diseases, and other conditions associated with aberrant cell signaling. BPH-628 can be utilized to study the role of GGPPS in various biological processes and to explore potential therapeutic interventions.

Cat. No.

B19258

CAS No.

1266548-74-6

Hyzetimibe

Synonyms: HS-25

Hyzetimibe is a cholesterol absorption inhibitor that effectively reduces the intestinal uptake of cholesterol and phytosterols. This compound demonstrates a favorable safety profile in animal studies, achieving a maximum tolerated dose of 2000 mg/kg in rats and 500 mg/kg in rhesus monkeys. Research applications include studies on lipid metabolism and the evaluation of therapeutic strategies for hypercholesterolemia.

Cat. No.

B19808

CAS No.

2890760-43-5

OSBP-IN-1

OSBP-IN-1 is an oxysterol-binding protein (OSBP) inhibitor that serves as a valuable tool in cancer research. This compound demonstrates significant antitumor activity, making it relevant for studies aimed at understanding OSBP's role in tumor biology and potential therapeutic interventions. Researchers can utilize OSBP-IN-1 to investigate the mechanistic pathways involved in cancer progression and to explore new treatment strategies targeting OSBP-related pathways.

Cat. No.

B20436

CAS No.

1059677-12-1

BPH-742

BPH-742 is an inhibitor of geranylgeranyl diphosphate synthase (GGPPS) with an IC50 of 0.1 μM. This compound demonstrates significant antitumor activity, making it a valuable tool for cancer research. BPH-742 can be used to study the biochemical pathways involved in tumor progression and to explore the therapeutic potential of targeting GGPPS in various cancer models.

Cat. No.

B20716

CAS No.

608135-02-0

Lanopylin B1

Lanopylin B1 is a selective inhibitor of lanosterol synthase (EC 5.4.99.7), with an IC50 value of 33 μM. This compound plays a significant role in the study of sterol biosynthesis and has potential applications in investigating cholesterol metabolism and related pathways in various biological contexts. Its ability to hinder lanosterol synthesis makes it a useful tool for exploring the mechanisms of lipid regulation and associated diseases.

Cat. No.

B21179

CAS No.

679411-86-0

Lanopylin B2

Lanopylin B2 is an inhibitor of lanosterol synthase (EC 5.4.99.7), demonstrating effective inhibition with an IC50 of 41 μM. This compound serves as a valuable tool for research into cholesterol biosynthesis and related metabolic pathways. Its ability to selectively target lanosterol synthase positions it for use in studies investigating the role of sterols in cellular processes and potential therapeutic applications.

Cat. No.

B21218

CAS No.

608135-01-9

Lanopylin A1

Lanopylin A1 is a selective inhibitor of lanosterol synthase (EC 5.4.99.7), a key enzyme in the sterol biosynthesis pathway. It exhibits an IC50 of 15 μM, demonstrating significant potency in modulating this target. This compound is useful for investigating the role of lanosterol synthase in cholesterol biosynthesis and related metabolic processes, making it valuable in studies of sterol metabolism and potential therapeutic interventions.