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Stearoyl-CoA Desaturase (SCD)

SCD inhibitors block stearoyl-CoA desaturase, the enzyme that makes monounsaturated fatty acids. Stearoyl-coenzyme A desaturase (SCD) inserts a cis double bond at the delta-9 position of palmitoyl-CoA and stearoyl-CoA. Its products, palmitoleate and oleate, are built into triglycerides, phospholipids and cholesteryl esters. In 2002, mice lacking SCD1 were shown to be protected against adiposity, which drew interest to the enzyme in metabolic research. A 2015 X-ray structure of mouse SCD1 showed how this membrane enzyme holds its acyl-CoA substrate. A939572, CAY10566 and XEN723 are SCD1 inhibitors, and MK-8245 was designed to act mainly in the liver. SC-26196 inhibits delta-6 desaturase instead, a related fatty acid desaturase.

Items 26-34 of 34

  • SW203668 TFA
    Cat. No.
    A77855
    CAS No.
    2117405-48-6

    SW203668 TFA

    SW203668 TFA is an irreversible inhibitor of stearoyl CoA desaturase (SCD), exhibiting an IC50 of 54 nM. By covalently binding to SCD, it effectively depletes unsaturated fatty acids and induces cell death in sensitive cell types, particularly those expressing CYP4F11. This selective cytotoxicity renders SW203668 TFA particularly valuable in the research of non-small cell lung cancer (NSCLC), as it inhibits tumor growth in CYP4F11-expressing xenografts while sparing other cell types. Its unique mechanism makes it a potent tool for studying targeted therapies in cancer treatment.

    In stock View Details
    1 mg
    $65.00
    5 mg
    $210.00
    All 3 sizes
  • XEN103
    Cat. No.
    A77857
    CAS No.
    840489-44-3

    XEN103

    XEN103 is a selective inhibitor of stearoyl-CoA desaturase 1 (SCD1), exhibiting IC50 values of 14 nM and 12 nM against mouse SCD1 and human SCD1 in HepG2 cells, respectively. This compound plays a significant role in research related to obesity and type 2 diabetes by modulating lipid metabolism. Additionally, XEN103 has been shown to induce sebaceous gland atrophy in murine models, providing further avenues for study in dermatological and metabolic disorders.

    In stock View Details
    25 mg
    $1,275.00
    50 mg
    $1,625.00
    All 3 sizes
  • SCD1-IN-1
    Cat. No.
    A77858
    CAS No.
    1111078-63-7

    SCD1-IN-1

    SCD1-IN-1 is a selective inhibitor of stearoyl-CoA desaturase 1 (SCD1), with an IC50 value of 5.8 nM. This compound is primarily used in research focused on dermatological conditions, where modulation of fatty acid metabolism may influence disease outcomes. SCD1-IN-1's ability to inhibit SCD1 makes it a valuable tool for studying the underlying mechanisms of skin-related pathologies and potential therapeutic approaches.

    In stock View Details
    25 mg
    $1,275.00
    50 mg
    $1,625.00
    All 3 sizes
  • SW203668
    Cat. No.
    A77859
    CAS No.
    1673556-40-5

    SW203668

    SW203668 is an irreversible inhibitor of stearoyl CoA desaturase (SCD) with an IC50 of 54 nM. It covalently binds to SCD, leading to the depletion of unsaturated fatty acids and triggering cell death in sensitive cells. Notably, SW203668's effectiveness is influenced by the expression of CYP4F11, as its active form is generated through demethylation by this enzyme, resulting in selective toxicity towards CYP4F11-expressing non-small cell lung cancer (NSCLC) cells. Additionally, SW203668 has demonstrated the ability to inhibit tumor growth in immunodeficient mice with NSCLC xenografts while sparing CYP4F11-lacking cells and mouse skin sebocytes, making it a valuable tool for research on non-small cell lung cancer.

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    Out of stock

    All 3 sizes
  • MK-8245 analog
    Cat. No.
    A77860
    CAS No.
    1030612-87-3

    MK-8245 analog

    MK-8245 analog is a potent inhibitor of stearoyl-CoA desaturase (SCD), exhibiting an IC50 of 7 nM in rat SCD assays. This compound demonstrates significant antidiabetic and antidyslipidemic activities, making it a valuable tool for research in metabolic disorders. Its mechanism of action provides opportunities for investigating SCD-related pathways in various biological contexts.

    In stock View Details
    1 mg
    $70.00
    2 mg
    $105.00
    All 8 sizes
  • Cbz-D-Trp-OH
    Cat. No.
    A77861
    CAS No.
    2279-15-4

    Cbz-D-Trp-OH

    Cbz-D-Trp-OH is a competitive inhibitor of stearoyl-CoA desaturase (SCD), demonstrating an IC50 of 86 μM and a Ki value of 71 μM. This compound modulates lipid biosynthesis and is instrumental in studying lipid metabolism and related metabolic disorders. Its use is pertinent in research focused on understanding the role of SCD in obesity, diabetes, and cardiovascular diseases.

    In stock View Details
    25 g
    $20.00
    All 1 sizes
  • SCD1 inhibitor-5
    Cat. No.
    A77862
    CAS No.
    1673558-59-2

    SCD1 inhibitor-5

    SCD1 inhibitor-5 is a selective inhibitor of stearoyl-CoA desaturase-1 (SCD1), exhibiting IC50 values of 0.13 μM in H2122 cells and 31 μM in H1819 cells. This compound effectively reduces SCD1 activity, making it a valuable tool in cancer research. Its inhibition of lipid metabolism pathways can provide insights into tumor growth and proliferation mechanisms.

    In stock View Details
    1 mg
    $55.00
    5 mg
    $130.00
    All 7 sizes
  • 1-Methyl-1H-pyrazole-3-carboxylic acid
    Cat. No.
    A91140
    CAS No.
    25016-20-0

    1-Methyl-1H-pyrazole-3-carboxylic acid

    1-Methyl-1H-pyrazole-3-carboxylic acid serves as an intermediate in the synthesis of SCD1 and SCD5 inhibitors. This compound is instrumental in investigating metabolic disorders and their mechanisms. Its role in the development of targeted therapies makes it a valuable reagent for chemical research in metabolic pathways.

    In stock View Details
    5 g
    $20.00
    10 g
    $25.00
    All 2 sizes
  • PF-244
    Cat. No.
    A95657
    CAS No.
    33979-27-0

    PF-244

    PF-244 is a drug derivative that functions as a selective inhibitor of stearoyl-CoA desaturase (SCD). This compound demonstrates significant biological activity by modulating lipid metabolism and may influence cellular processes related to insulin sensitivity and obesity. PF-244 is commonly utilized in research applications focused on metabolic disorders and provides valuable insights into lipid-related pathophysiology.

    In stock View Details
    25 mg
    $1,275.00
    50 mg
    $1,625.00
    All 3 sizes

Items 26-34 of 34

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