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Browse fluorescein dyes and derivatives supported by product-specific catalog or supplier information. Review the exact chemical form and product specifications before selecting a reagent.
A fluorescein-family relationship does not establish intracellular pH sensing, calcium detection or labeling compatibility for every derivative. These applications require their own product-specific evidence.
Synonyms: FDG
Fluorescein di(β-D-galactopyranoside) is a fluorogenic substrate for β-galactosidase (λex=485 nm, λem=535 nm).
Synonyms: 3,6-Diacetoxyfluoran; Di-O-acetylfluorescein
Fluorescein diacetate is a fluorogenic substrate that functions as a cell-permeable esterase substrate. Upon cleavage by cellular esterases, it yields fluorescein, which is highly fluorescent and allows for the visualization of viable cells. This compound is particularly useful in studies involving hGSTP1-1 and can be applied in assays for cell viability and drug response.
Fluorescein-6-carbonyl-Asp(OMe)-Glu(OMe)-Val-DL-Asp(OMe)-fluoromethylketone is a potent and cell-permeable inhibitor of caspase-3, acting through irreversible binding to the activated form in apoptotic cells. This reagent exhibits significant fluorescence, allowing for quantitative analysis via flow cytometry, microwell plate readers, or fluorescence microscopy. Its application is crucial for studying apoptosis and characterizing caspase-3 activity in various biological systems.
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HS-27 is a fluorescently-tethered inhibitor targeting Heat Shock Protein 90 (Hsp90), facilitating the assessment of surface Hsp90 expression on intact tissue specimens. Comprising core elements of SNX-5422 linked through a PEG spacer to a fluorescein derivative, HS-27 selectively binds to ectopically expressed Hsp90. This reagent is particularly valuable in breast cancer research, providing a tool for applications involving visualization and treatment strategies.
5(6)-Carboxynaphthofluorescein diacetate is a specific fluorescent substrate utilized in esterase assays. It is cleaved by intracellular esterases, leading to the production of red fluorescence, which can be quantitatively measured to assess enzyme activity. This compound is instrumental in various biological and biochemical research applications, including monitoring esterase activity in live cells.
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Fluorescein Di-β-D-Glucopyranoside acts as a specific substrate for β-glucocerebrosidase. This fluorogenic compound is primarily utilized in studies involving lysosomal enzyme activity, particularly intralysosomal β-galactosidase. Its structural properties enable effective detection and quantification of enzyme activity, making it a valuable tool in enzyme assays and research related to lysosomal storage disorders.
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Synonyms: DBF
Dibenzylfluorescein is a fluorogenic probe that serves as a substrate for specific cytochrome P450 isoforms, notably CYP3A4, CYP2C8, CYP2C9, CYP2C19, and aromatase (CYP19). This compound, with optimal usage near its Km value of 0.87-1.9 μM (Ex=485 nm, Em=535 nm), is instrumental in assessing alterations in CYP catalytic activity resulting from pharmaceuticals or pathological conditions. Dibenzylfluorescein is widely utilized in drug metabolism studies and toxicity assessments, providing insights into enzyme function in biochemical and pharmacological research.
Atrovastatin-PEG3-FITC is a KRAS-PDEδ interaction inhibitor that serves as a valuable tool in the study of KRAS signaling pathways. This compound can function as a ligand in fluorescence anisotropy assays, enabling researchers to investigate protein-protein interactions and their implications in cancer biology. Its application aids in understanding the role of KRAS in various malignancies and exploring potential therapeutic interventions.
Synonyms: Naphthafluorescein
Naphthofluorescein is a potent inhibitor of HIF-1 through the inhibition of HIF prolyl-hydroxylase activity. It effectively suppresses Mint3-dependent HIF-1 signaling and glycolytic activity in cancer cells and macrophages while exhibiting low cytotoxicity in vitro and negligible adverse effects in vivo. Additionally, Naphthofluorescein serves as a fluorescent pH-sensitive probe, making it suitable for functional Cerenkov imaging applications.
FITC-YVADAPK(Dnp) is a fluorogenic substrate primarily used to study caspase-1 activity. Upon cleavage by caspase-1, the fluorescence intensity increases, allowing for quantitative analysis of enzyme activity in various biological samples. This reagent is suitable for applications in apoptosis research and the investigation of inflammatory responses.
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