HCV Protease

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

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  1. HCV-IN-3

    Catalog No. A20957
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    HCV NS3/4a protein inhibitor
    HCV-IN-3 is a hepatitis C virus (HCV) NS3/4a protein inhibitor, with an IC50 of 20 μM, a Kd of 29 μM. Learn More
  2. Paritaprevir (ABT-450)

    Catalog No. A17625
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    HCV NS3/4A inhibitor
    Paritaprevir (ABT-450) is a potent non-structural protein 3/4A (NS3/4A) protease inhibitor with EC50s of 1 and 0.21 nM against HCV 1a and 1b, respectively. Learn More
  3. Ombitasvir (ABT-267)

    Catalog No. A17624
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    HCV NS5A inhibitor
    Ombitasvir is a potent inhibitor of the hepatitis C virus protein NS5A, with EC50s of 0.82 to 19.3 pM against HCV genotypes 1 to 5, and 366 pM against genotype 6a. Learn More
  4. Velpatasvir

    Catalog No. A17302
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    HCV NS5A inhibitor
    Velpatasvir, also known as GS-5816, is a potent and selective Hepatitis C virus NS5A inhibitor. Learn More
  5. Vaniprevir

    Catalog No. A11600
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    HCV NS3/4A protease inhibitor
    Vaniprevir is a non-covalent competitive inhibitor of the hepatitis C virus (HCV) NS3/4A protease. Learn More
  6. Simeprevir

    Catalog No. A11580
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    HCV NS3/4A protease inhibitor
    Simeprevir is a potent inhibitor of HCV NS3/4A protease (Ki = 0.36 nM) and viral replication (replicon EC50 = 7.8 nM). Learn More
  7. Nesbuvir

    Catalog No. A11510
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    HCV Polymerase Inhibitor
    HCV-796 is a selectively inhibitor of hepatitis C virus (HCV) NS5B RNA-dependent RNA polymerase. Learn More
  8. VCH-759

    Catalog No. A15479
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    HCV Polymerase Inhibitor
    VCH-759 is a non-nucleoside inhibitor of HCV RNA-dependent polymerase with sub-micromolar IC50 values versus genotype 1a/1b replicons. Learn More
  9. RO-9187

    Catalog No. A15224
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    HCV replication inhibitor
    RO-9187 is a potent inhibitor of HCV virus replication in the replicon system (IC(50) = 171 +/- 12 nM; CC(50) >1 mM). Learn More
  10. MK-5172 sodium salt

    Catalog No. A15168
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    HCV Protease inhibitor
    MK-5172 is a novel P2-P4 quinoxaline macrocyclic HCV NS3/4a protease inhibitor currently in clinical development. Learn More
  11. MK-5172 potassium salt

    Catalog No. A15167
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    HCV Protease inhibitor
    MK-5172 is a novel P2-P4 quinoxaline macrocyclic HCV NS3/4a protease inhibitor currently in clinical development. Learn More
  12. Ledipasvir acetone

    Catalog No. A18055
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    HCV NS5A inhibitor
    Ledipasvir acetone is the active pharmaceutical ingredient of Ledipasvir. Ledipasvir is an inhibitor of the hepatitis C virus NS5A, with EC50 values of 34 pM against GT1a and 4 pM against GT1b replicon. Learn More
  13. Voxilaprevir

    Catalog No. A12067
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    HCV NS3/4A protease inhibitor
    Voxilaprevir (GS-9857) is a fluorinated macrocyclic hepatitis C virus (HCV) nonstructural protein (NS) 3/4A protease inhibitor with potent in vitro antiviral activity against genotypes 1-6 HCV and broad coverage of NS3/4A protease polymorphisms. GS-9857 improves coverage against commonly encountered NS3 resistance-associated variants (RAVs). Learn More
  14. PSI-6206 13CD3

    Catalog No. A21782
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    HCV NS5B polymerase inhibitor
    PSI-6206 13CD3 is the deuterium labeled PSI-6206. PSI-6206 is the deaminated derivative of PSI-6130, which is a potent and selective inhibitor of HCV NS5B polymerase. Learn More
  15. NM107

    Catalog No. A21761
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    HCV NS5B polymerase inhibitor
    NM107 (2'-C-Methylcytidine) is an nucleoside inhibitor of the hepatitis C virus (HCV) NS5B polymerase, the EC50 of NM107 in the wild-type replicon cells is 1.85 μM. Learn More
  16. Sofosbuvir impurity A

    Catalog No. A21641
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    HCV RNA replication inhibitor
    Sofosbuvir impurity A, an diastereoisomer of sofosbuvir, is the impurity of sofosbuvir. Sofosbuvir (PSI-7977) is an inhibitor of HCV RNA replication, demonstrates potent anti-hepatitis C virus activity. Learn More
  17. Sofosbuvir impurity C

    Catalog No. A21636
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    HCV RNA replication inhibitor
    Sofosbuvir impurity C is the less active impurity of Sofosbuvir, Sofosbuvir is an active inhibitor of HCV RNA replication in the HCV replicon assay, demonstrates potent anti-hepatitis C virus (HCV) activity. Learn More
  18. PSI-7976

    Catalog No. A21631
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    HCV RNA replication inhibitor
    PSI-7976 is the isomer of PSI-7977. PSI-7977 is an active inhibitor of HCV RNA replication in the HCV replicon assay, demonstrates potent anti-hepatitis C virus (HCV) activity. Learn More
  19. Beclabuvir

    Catalog No. A21511
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    HCV NS5B RNA-dependent RNA polymerase inhibitor
    Beclabuvir is an allosteric inhibitor that binds to thumb site 1 of the hepatitis C virus (HCV) NS5B RNA-dependent RNA polymerase, and inhibits recombinant NS5B proteins from HCV genotypes 1, 3, 4, and 5 with IC50 of < 28 nM. Learn More
  20. PSI-352938

    Catalog No. A21253
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    HCV nucleotide inhibitor
    PSI-352938 (PSI-938) is a hepatitis C virus (HCV) nucleotide inhibitor. Learn More
  21. R-1479

    Catalog No. A11540
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    HCV replication inhibitor
    R-1479 is a specific inhibitor of HCV replication in the HCV subgenomic replicon system (IC50=1.28 μM). Learn More
  22. Mericitabine

    Catalog No. A11539
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    HCV NS5B polymerase inhibitor
    Mericitabine (RG 7128; R-7128) is a nucleoside inhibitor of the HCV NS5B polymerase that acts as an RNA chain terminator and prevents elongation of RNA transcripts during replication. Learn More
  23. PSI-7409

    Catalog No. A13962
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    nucleotide analog HCV inhibitor
    PSI-7409 is the active 5'-triphosphate metabolite of Sofosbuvir (PSI-7977). Sofosbuvir (PSI-7977) is a selective and highly active nucleotide analog inhibitor of HCV. Learn More
  24. MK-5172 hydrate

    Catalog No. A15166
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    HCV Protease inhibitor
    MK-5172 is a novel P2-P4 quinoxaline macrocyclic HCV NS3/4a protease inhibitor currently in clinical development. Learn More
  25. BMS-790052 (Daclatasvir)

    Catalog No. A10159
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    HCV NS5A inhibitor
    BMS-790052 is an NS5A inhibitor under investigation for the treatment of hepatitis C virus (HCV) infection. Learn More
  26. Tegobuvir (GS-9190)

    Catalog No. A11583
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    NS5B polymerase inhibitor
    Tegobuvir (GS-9190 is a non-nucleoside NS5B polymerase inhibitor. Learn More
  27. PSI-6130

    Catalog No. A11519
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    HCV Nucleoside Inhibitor
    PSI-6130(R 1656) is a Hepatitis C Virus Nucleoside Inhibitor. Learn More
  28. Ciluprevir (BILN 2061)

    Catalog No. A11343
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    HCV NS3 protease Inhibitor
    Ciluprevir is a specific and potent peptidomimetic inhibitor of the HCV NS3 protease. Learn More
  29. BMS-790052 2HCl

    Catalog No. A11336
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    NS5A inhibitor
    BMS-790052 is an NS5A inhibitor under investigation for the treatment of hepatitis C virus (HCV) infection. Learn More
  30. Balapiravir (R1626)

    Catalog No. A11335
    Polymerase inhibitor
    Balapiravir (R1626, RG1626) is the prodrug of a nucleoside analogue inhibitor of the hepatitis C virus (HCV) RNA-dependent RNA polymerase (R1479, RG1479). Learn More
  31. Boceprevir (SCH-503034)

    Catalog No. A11332
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    HCV Protease Inhibitor
    Boceprevir is a protease inhibitor used as a treatment for hepatitis C genotype 1. Learn More
  32. Asunaprevir (BMS-650032)

    Catalog No. A11295
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    NS3 protease inhibitor
    Asunaprevir is an inhibitor of the viral enzyme serine protease NS3. Learn More
  33. Anguizole

    Catalog No. A11294
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    HCV replication Inhibitor
    Anguizole is a small molecule inhibits HCV replication and alters NS4B's subcellular distribution. Learn More
  34. Telaprevir (VX-950)

    Catalog No. A10902
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    HCV NS3-4A protease inhibitor
    Telaprevir (VX-950) is known as protease inhibitors that inhibits the hepatitis C virus NS3.4A serine protease. Learn More
  35. VX-222

    Catalog No. A10980
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    HCV Protease inhibitor
    VX-222 is a small molecule non-nucleoside inhibitor of HCV NS5B polymerase that is being investigated for the treatment of hepatitis C virus infection. Learn More
  36. Danoprevir (RG7227)

    Catalog No. A10284
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    HCV NS3/4A protease inhibitor
    Danoprevir is a potent inhibitor of the HCV NS3/4A serine protease. Learn More
  37. VCH-916

    Catalog No. A12374
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    HCV NS5B polymerase inhibitor
    VCH-916 is a novel nonnucleoside HCV NS5B polymerase inhibitor. Learn More
  38. Setrobuvir (ANA-598)

    Catalog No. A13105
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    HCV Polymerase Inhibitor
    Setrobuvir (ANA-598) is a direct-acting antiviral or DAA, is a non-nucleoside inhibitor of the HCV RNA polymerase Learn More
  39. GS-9451

    Catalog No. A14046
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    HCV NS3/4A protease inhibitor
    GS-9451, a novel hepatitis C virus (HCV) nonstructural 3/4a (NS3/4a) protease inhibitor, is highly active in patients infected with HCV genotype 1 (GT 1). Learn More
  40. MK 8742 (elbasvir)

    Catalog No. A13965
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    HCV NS5A inhibitor
    MK 8742, also known as Elbasvir, is a HCV NS5A inhibitor, which is an all-oral, interferon-free regimen for the treatment of HCV infection. Learn More
  41. Faldaprevir

    Catalog No. A14106
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    HCV Protease Inhibitor
    Faldaprevir is a hepatitis C virus protease inhibitor. Learn More
  42. PSI-6206

    Catalog No. A11530
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    HCV RNA polymerase inhibitor
    PSI-6206 is the deaminated derivative of PSI-6130, which is a potent inhibitor of hepatitis C virus (HCV) replication in the subgenomic HCV reolicon system. Learn More
  43. PSI-7977

    Catalog No. A11529
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    HCV Nucleotide Inhibitor
    PSI-7977 is a phosphoramidate prodrug of PSI-7851, a nucleoside analog that, when phosphorylated, inhibits the RNA-dependent RNA polymerase of hepatitis C virus (EC50 = 92 nM). Learn More
  44. Ledipasvir (GS 5885)

    Catalog No. A13155
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    NS5A inhibitor
    Ledipasvir is an inhibitor of the hepatitis C virus HCV NS5A protein Learn More
  45. Celgosivir

    Catalog No. A13118
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    alpha-glucosidase I inhibitor
    Celgosivir is an alpha-glucosidase I inhibitor for the potential treatment of HCV infection. Learn More
  46. Glecaprevir

    Catalog No. A16948
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    HCV NS3/4A protease inhibitor
    Glecaprevir, also known as ABT-493 and A-1282576, is a novel HCV NS3/4A protease inhibitor, with IC50 values ranging from 3.5 to 11.3 nM. Learn More
  47. Narlaprevir

    Catalog No. A11506
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    NS3 protease inhibitor
    Narlaprevir is a potent, selective, orally bioavailable NS3 protease inhibitor(Ki=6 nM; EC90=40 nM) Learn More
  48. MK-5172

    Catalog No. A13787
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    HCV NS3/4a inhibitor
    MK-5172 is a selective inhibitor of Hepatitis C virus NS3/4a protease with broad activity across genotypes and resistant variants. Learn More
  49. GS-9256

    Catalog No. A13526
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    HCV NS3 inhibitor
    GS-9451 is a potent macrocyclic HCV NS3 PI that achieved a median maximal change in HCV RNA of 3.6 log10 IU/mL (range, -4.7 log10 to -3.1 log10 IU/mL) following 3-day monotherapy in treatment-nave patients with HCV genotype 1 infection during phase I. Learn More
  50. BI207127 (Deleobuvir)

    Catalog No. A13414
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    HCV NS5B polymerase inhibitor
    BI 207127 was a non-nucleoside hepatitis C virus NS5B polymerase inhibitor for the treatment of hepatitis C Learn More

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