HCV Protease

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

33 Item(s)

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  1. BMS-790052 (Daclatasvir)

    Catalog No. A10159
    HCV NS5A inhibitor
    BMS-790052 is an NS5A inhibitor under investigation for the treatment of hepatitis C virus (HCV) infection. Learn More
  2. PSI-7977

    Catalog No. A11529
    HCV Nucleotide Inhibitor
    PSI-7977 is a phosphoramidate prodrug of PSI-7851, a nucleoside analog that, when phosphorylated, inhibits the RNA-dependent RNA polymerase of hepatitis C virus (EC50 = 92 nM). Learn More
  3. PSI-6206

    Catalog No. A11530
    HCV RNA polymerase inhibitor
    PSI-6206 is the deaminated derivative of PSI-6130, which is a potent inhibitor of hepatitis C virus (HCV) replication in the subgenomic HCV reolicon system. Learn More
  4. Faldaprevir

    Catalog No. A14106
    HCV Protease Inhibitor
    Faldaprevir is a hepatitis C virus protease inhibitor. Learn More
  5. MK 8742 (elbasvir)

    Catalog No. A13965
    HCV NS5A inhibitor
    MK 8742, also known as Elbasvir, is a HCV NS5A inhibitor, which is an all-oral, interferon-free regimen for the treatment of HCV infection. Learn More
  6. GS-9451

    Catalog No. A14046
    HCV NS3/4A protease inhibitor
    GS-9451, a novel hepatitis C virus (HCV) nonstructural 3/4a (NS3/4a) protease inhibitor, is highly active in patients infected with HCV genotype 1 (GT 1). Learn More
  7. MK-5172 hydrate

    Catalog No. A15166
    HCV inhibitor
    MK-5172 is a novel P2-P4 quinoxaline macrocyclic HCV NS3/4a protease inhibitor currently in clinical development. Learn More
  8. MK-5172 potassium salt

    Catalog No. A15167
    HCV inhibitor
    MK-5172 is a novel P2-P4 quinoxaline macrocyclic HCV NS3/4a protease inhibitor currently in clinical development. Learn More
  9. MK-5172 sodium salt

    Catalog No. A15168
    HCV inhibitor
    MK-5172 is a novel P2-P4 quinoxaline macrocyclic HCV NS3/4a protease inhibitor currently in clinical development. Learn More
  10. RO-9187

    Catalog No. A15224
    HCV replication inhibitor
    RO-9187 is a potent inhibitor of HCV virus replication in the replicon system (IC(50) = 171 +/- 12 nM; CC(50) >1 mM). Learn More
  11. VCH-759

    Catalog No. A15479
    HCV Polymerase Inhibitor
    VCH-759 is a non-nucleoside inhibitor of HCV RNA-dependent polymerase with sub-micromolar IC50 values versus genotype 1a/1b replicons. Learn More
  12. Nesbuvir

    Catalog No. A11510
    HCV Inhibitor
    HCV-796 is a selectively inhibitor of hepatitis C virus (HCV) NS5B RNA-dependent RNA polymerase. Learn More
  13. Simeprevir

    Catalog No. A11580
    HCV NS3/4A protease inhibitor
    Simeprevir is a potent inhibitor of HCV NS3/4A protease (Ki = 0.36 nM) and viral replication (replicon EC50 = 7.8 nM). Learn More
  14. Ledipasvir (GS 5885)

    Catalog No. A13155
    NS5A inhibitor
    Ledipasvir is an inhibitor of the hepatitis C virus HCV NS5A protein Learn More
  15. Celgosivir

    Catalog No. A13118
    alpha-glucosidase I inhibitor
    Celgosivir is an alpha-glucosidase I inhibitor for the potential treatment of HCV infection. Learn More
  16. Setrobuvir (ANA-598)

    Catalog No. A13105
    HCV Polymerase Inhibitor
    Setrobuvir (ANA-598) is a direct-acting antiviral or DAA, is a non-nucleoside inhibitor of the HCV RNA polymerase Learn More
  17. Danoprevir (RG7227)

    Catalog No. A10284
    HCV NS3/4A protease inhibitor
    Danoprevir is a potent inhibitor of the HCV NS3/4A serine protease. Learn More
  18. VX-222

    Catalog No. A10980
    HCV Protease inhibitor
    VX-222 is a small molecule non-nucleoside inhibitor of HCV NS5B polymerase that is being investigated for the treatment of hepatitis C virus infection. Learn More
  19. Telaprevir (VX-950)

    Catalog No. A10902
    HCV NS3-4A protease inhibitor
    Telaprevir (VX-950) is known as protease inhibitors that inhibits the hepatitis C virus NS3.4A serine protease. Learn More
  20. Anguizole

    Catalog No. A11294
    HCV replication Inhibitor
    Anguizole is a small molecule inhibits HCV replication and alters NS4B's subcellular distribution. Learn More
  21. Asunaprevir (BMS-650032)

    Catalog No. A11295
    NS3 protease inhibitor
    Asunaprevir is an inhibitor of the viral enzyme serine protease NS3. Learn More
  22. Boceprevir (SCH-503034)

    Catalog No. A11332
    HCV Protease Inhibitor
    Boceprevir is a protease inhibitor used as a treatment for hepatitis C genotype 1. Learn More
  23. Balapiravir (R1626)

    Catalog No. A11335
    Polymerase inhibitor
    Balapiravir (R1626, RG1626) is the prodrug of a nucleoside analogue inhibitor of the hepatitis C virus (HCV) RNA-dependent RNA polymerase (R1479, RG1479). Learn More
  24. Vaniprevir

    Catalog No. A11600
    HCV NS3/4A protease inhibitor
    Vaniprevir is a non-covalent competitive inhibitor of the hepatitis C virus (HCV) NS3/4A protease. Learn More
  25. VCH-916

    Catalog No. A12374
    HCV NS5B polymerase inhibitor
    VCH-916 is a novel nonnucleoside HCV NS5B polymerase inhibitor. Learn More
  26. Tegobuvir (GS-9190)

    Catalog No. A11583
    NS5B polymerase inhibitor
    Tegobuvir (GS-9190 is a non-nucleoside NS5B polymerase inhibitor. Learn More
  27. PSI-6130

    Catalog No. A11519
    HCV Nucleoside Inhibitor
    PSI-6130(R 1656) is a Hepatitis C Virus Nucleoside Inhibitor. Learn More
  28. Ciluprevir (BILN 2061)

    Catalog No. A11343
    HCV NS3 protease Inhibitor
    Ciluprevir is a specific and potent peptidomimetic inhibitor of the HCV NS3 protease. Learn More
  29. BMS-790052 2HCl

    Catalog No. A11336
    NS5A inhibitor
    BMS-790052 is an NS5A inhibitor under investigation for the treatment of hepatitis C virus (HCV) infection. Learn More
  30. MK-5172

    Catalog No. A13787
    HCV NS3/4a inhibitor
    MK-5172 is a selective inhibitor of Hepatitis C virus NS3/4a protease with broad activity across genotypes and resistant variants. Learn More
  31. Narlaprevir

    Catalog No. A11506
    NS3 protease inhibitor
    Narlaprevir is a potent, selective, orally bioavailable NS3 protease inhibitor(Ki=6 nM; EC90=40 nM) Learn More
  32. GS-9256

    Catalog No. A13526
    HCV NS3 inhibitor
    GS-9451 is a potent macrocyclic HCV NS3 PI that achieved a median maximal change in HCV RNA of 3.6 log10 IU/mL (range, -4.7 log10 to -3.1 log10 IU/mL) following 3-day monotherapy in treatment-nave patients with HCV genotype 1 infection during phase I. Learn More
  33. BI207127 (Deleobuvir)

    Catalog No. A13414
    HCV NS5B polymerase inhibitor
    BI 207127 was a non-nucleoside hepatitis C virus NS5B polymerase inhibitor for the treatment of hepatitis C Learn More

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