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$0.00 HCV Protease
| Catalog No. | Inhibitor Name | HCV Protease |
|---|---|---|
| A10159 | Daclatasvir (BMS-790052) | **** |
| A10902 | Telaprevir (VX-950) | ** |
| A10980 | Lomibuvir (VX-222, VCH-222) | * |
| A10284 | Danoprevir (ITMN-191) | *** |
| A13155 | Ledipasvir (GS5885) | |
| A11294 | Anguizole | ** |
| A11295 | Asunaprevir (BMS-650032) | **** |
| A11332 | Boceprevir (SCH-503034) | *** |
| A11343 | Ciluprevir (BILN 2061) | *** |
| A11580 | Simeprevir | **** |
Notes:
1.Hover mouse over "" to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of "" is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.
50 Item(s)
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Voxilaprevir
Catalog No. A12067 HCV NS3/4A protease inhibitorVoxilaprevir (GS-9857) is a fluorinated macrocyclic hepatitis C virus (HCV) nonstructural protein (NS) 3/4A protease inhibitor with potent in vitro antiviral activity against genotypes 1-6 HCV and broad coverage of NS3/4A protease polymorphisms. GS-9857 improves coverage against commonly encountered NS3 resistance-associated variants (RAVs). Learn More -
BMS-790052 (Daclatasvir)
Catalog No. A10159 HCV NS5A inhibitorBMS-790052 is an NS5A inhibitor under investigation for the treatment of hepatitis C virus (HCV) infection. Learn More -
MK-5172 sodium salt
Catalog No. A15168 HCV Protease inhibitorMK-5172 is a novel P2-P4 quinoxaline macrocyclic HCV NS3/4a protease inhibitor currently in clinical development. Learn More -
RO-9187
Catalog No. A15224 HCV replication inhibitorRO-9187 is a potent inhibitor of HCV virus replication in the replicon system (IC(50) = 171 +/- 12 nM; CC(50) >1 mM). Learn More -
VCH-759
Catalog No. A15479 HCV Polymerase InhibitorVCH-759 is a non-nucleoside inhibitor of HCV RNA-dependent polymerase with sub-micromolar IC50 values versus genotype 1a/1b replicons. Learn More -
Nesbuvir
Catalog No. A11510 HCV Polymerase InhibitorHCV-796 is a selectively inhibitor of hepatitis C virus (HCV) NS5B RNA-dependent RNA polymerase. Learn More -
Simeprevir
Catalog No. A11580 HCV NS3/4A protease inhibitorSimeprevir is a potent inhibitor of HCV NS3/4A protease (Ki = 0.36 nM) and viral replication (replicon EC50 = 7.8 nM). Learn More -
Vaniprevir
Catalog No. A11600 HCV NS3/4A protease inhibitorVaniprevir is a non-covalent competitive inhibitor of the hepatitis C virus (HCV) NS3/4A protease. Learn More -
Velpatasvir
Catalog No. A17302 HCV NS5A inhibitorVelpatasvir, also known as GS-5816, is a potent and selective Hepatitis C virus NS5A inhibitor. Learn More -
Ombitasvir (ABT-267)
Catalog No. A17624 HCV NS5A inhibitorOmbitasvir is a potent inhibitor of the hepatitis C virus protein NS5A, with EC50s of 0.82 to 19.3 pM against HCV genotypes 1 to 5, and 366 pM against genotype 6a. Learn More -
Paritaprevir (ABT-450)
Catalog No. A17625 HCV NS3/4A inhibitorParitaprevir (ABT-450) is a potent non-structural protein 3/4A (NS3/4A) protease inhibitor with EC50s of 1 and 0.21 nM against HCV 1a and 1b, respectively. Learn More -
Ledipasvir acetone
Catalog No. A18055 HCV NS5A inhibitorLedipasvir acetone is the active pharmaceutical ingredient of Ledipasvir. Ledipasvir is an inhibitor of the hepatitis C virus NS5A, with EC50 values of 34 pM against GT1a and 4 pM against GT1b replicon. Learn More -
MK-5172 potassium salt
Catalog No. A15167 HCV Protease inhibitorMK-5172 is a novel P2-P4 quinoxaline macrocyclic HCV NS3/4a protease inhibitor currently in clinical development. Learn More -
PSI-7409
Catalog No. A13962 nucleotide analog HCV inhibitorPSI-7409 is the active 5'-triphosphate metabolite of Sofosbuvir (PSI-7977). Sofosbuvir (PSI-7977) is a selective and highly active nucleotide analog inhibitor of HCV. Learn More -
Mericitabine
Catalog No. A11539 HCV NS5B polymerase inhibitorMericitabine (RG 7128; R-7128) is a nucleoside inhibitor of the HCV NS5B polymerase that acts as an RNA chain terminator and prevents elongation of RNA transcripts during replication. Learn More -
R-1479
Catalog No. A11540 HCV replication inhibitorR-1479 is a specific inhibitor of HCV replication in the HCV subgenomic replicon system (IC50=1.28 μM). Learn More -
PSI-352938
Catalog No. A21253 HCV nucleotide inhibitorPSI-352938 (PSI-938) is a hepatitis C virus (HCV) nucleotide inhibitor. Learn More -
Beclabuvir
Catalog No. A21511 HCV NS5B RNA-dependent RNA polymerase inhibitorBeclabuvir is an allosteric inhibitor that binds to thumb site 1 of the hepatitis C virus (HCV) NS5B RNA-dependent RNA polymerase, and inhibits recombinant NS5B proteins from HCV genotypes 1, 3, 4, and 5 with IC50 of < 28 nM. Learn More -
PSI-7976
Catalog No. A21631 HCV RNA replication inhibitorPSI-7976 is the isomer of PSI-7977. PSI-7977 is an active inhibitor of HCV RNA replication in the HCV replicon assay, demonstrates potent anti-hepatitis C virus (HCV) activity. Learn More -
Sofosbuvir impurity C
Catalog No. A21636 HCV RNA replication inhibitorSofosbuvir impurity C is the less active impurity of Sofosbuvir, Sofosbuvir is an active inhibitor of HCV RNA replication in the HCV replicon assay, demonstrates potent anti-hepatitis C virus (HCV) activity. Learn More -
Sofosbuvir impurity A
Catalog No. A21641 HCV RNA replication inhibitorSofosbuvir impurity A, an diastereoisomer of sofosbuvir, is the impurity of sofosbuvir. Sofosbuvir (PSI-7977) is an inhibitor of HCV RNA replication, demonstrates potent anti-hepatitis C virus activity. Learn More -
NM107
Catalog No. A21761 HCV NS5B polymerase inhibitorNM107 (2'-C-Methylcytidine) is an nucleoside inhibitor of the hepatitis C virus (HCV) NS5B polymerase, the EC50 of NM107 in the wild-type replicon cells is 1.85 μM. Learn More -
PSI-6206 13CD3
Catalog No. A21782 HCV NS5B polymerase inhibitorPSI-6206 13CD3 is the deuterium labeled PSI-6206. PSI-6206 is the deaminated derivative of PSI-6130, which is a potent and selective inhibitor of HCV NS5B polymerase. Learn More -
HCV-IN-3
Catalog No. A20957 HCV NS3/4a protein inhibitorHCV-IN-3 is a hepatitis C virus (HCV) NS3/4a protein inhibitor, with an IC50 of 20 μM, a Kd of 29 μM. Learn More -
Setrobuvir (ANA-598)
Catalog No. A13105 HCV Polymerase InhibitorSetrobuvir (ANA-598) is a direct-acting antiviral or DAA, is a non-nucleoside inhibitor of the HCV RNA polymerase Learn More -
Danoprevir (RG7227)
Catalog No. A10284 HCV NS3/4A protease inhibitorDanoprevir is a potent inhibitor of the HCV NS3/4A serine protease. Learn More -
VX-222
Catalog No. A10980 HCV Protease inhibitorVX-222 is a small molecule non-nucleoside inhibitor of HCV NS5B polymerase that is being investigated for the treatment of hepatitis C virus infection. Learn More -
Telaprevir (VX-950)
Catalog No. A10902 HCV NS3-4A protease inhibitorTelaprevir (VX-950) is known as protease inhibitors that inhibits the hepatitis C virus NS3.4A serine protease. Learn More -
Anguizole
Catalog No. A11294 HCV replication InhibitorAnguizole is a small molecule inhibits HCV replication and alters NS4B's subcellular distribution. Learn More -
Asunaprevir (BMS-650032)
Catalog No. A11295 NS3 protease inhibitorAsunaprevir is an inhibitor of the viral enzyme serine protease NS3. Learn More -
Boceprevir (SCH-503034)
Catalog No. A11332 HCV Protease InhibitorBoceprevir is a protease inhibitor used as a treatment for hepatitis C genotype 1. Learn More -
Balapiravir (R1626)
Catalog No. A11335 Polymerase inhibitorBalapiravir (R1626, RG1626) is the prodrug of a nucleoside analogue inhibitor of the hepatitis C virus (HCV) RNA-dependent RNA polymerase (R1479, RG1479). Learn More -
BMS-790052 2HCl
Catalog No. A11336 NS5A inhibitorBMS-790052 is an NS5A inhibitor under investigation for the treatment of hepatitis C virus (HCV) infection. Learn More -
Ciluprevir (BILN 2061)
Catalog No. A11343 HCV NS3 protease InhibitorCiluprevir is a specific and potent peptidomimetic inhibitor of the HCV NS3 protease. Learn More -
PSI-6130
Catalog No. A11519 HCV Nucleoside InhibitorPSI-6130(R 1656) is a Hepatitis C Virus Nucleoside Inhibitor. Learn More -
Tegobuvir (GS-9190)
Catalog No. A11583 NS5B polymerase inhibitorTegobuvir (GS-9190 is a non-nucleoside NS5B polymerase inhibitor. Learn More -
VCH-916
Catalog No. A12374 HCV NS5B polymerase inhibitorVCH-916 is a novel nonnucleoside HCV NS5B polymerase inhibitor. Learn More -
MK-5172 hydrate
Catalog No. A15166 HCV Protease inhibitorMK-5172 is a novel P2-P4 quinoxaline macrocyclic HCV NS3/4a protease inhibitor currently in clinical development. Learn More -
Celgosivir
Catalog No. A13118 alpha-glucosidase I inhibitorCelgosivir is an alpha-glucosidase I inhibitor for the potential treatment of HCV infection. Learn More -
Ledipasvir (GS 5885)
Catalog No. A13155 NS5A inhibitorLedipasvir is an inhibitor of the hepatitis C virus HCV NS5A protein Learn More -
PSI-7977
Catalog No. A11529 HCV Nucleotide InhibitorPSI-7977 is a phosphoramidate prodrug of PSI-7851, a nucleoside analog that, when phosphorylated, inhibits the RNA-dependent RNA polymerase of hepatitis C virus (EC50 = 92 nM). Learn More -
PSI-6206
Catalog No. A11530 HCV RNA polymerase inhibitorPSI-6206 is the deaminated derivative of PSI-6130, which is a potent inhibitor of hepatitis C virus (HCV) replication in the subgenomic HCV reolicon system. Learn More -
Faldaprevir
Catalog No. A14106 HCV Protease InhibitorFaldaprevir is a hepatitis C virus protease inhibitor. Learn More -
MK 8742 (elbasvir)
Catalog No. A13965 HCV NS5A inhibitorMK 8742, also known as Elbasvir, is a HCV NS5A inhibitor, which is an all-oral, interferon-free regimen for the treatment of HCV infection. Learn More -
GS-9451
Catalog No. A14046 HCV NS3/4A protease inhibitorGS-9451, a novel hepatitis C virus (HCV) nonstructural 3/4a (NS3/4a) protease inhibitor, is highly active in patients infected with HCV genotype 1 (GT 1). Learn More -
Glecaprevir
Catalog No. A16948 HCV NS3/4A protease inhibitorGlecaprevir, also known as ABT-493 and A-1282576, is a novel HCV NS3/4A protease inhibitor, with IC50 values ranging from 3.5 to 11.3 nM. Learn More -
Narlaprevir
Catalog No. A11506 NS3 protease inhibitorNarlaprevir is a potent, selective, orally bioavailable NS3 protease inhibitor(Ki=6 nM; EC90=40 nM) Learn More -
MK-5172
Catalog No. A13787 HCV NS3/4a inhibitorMK-5172 is a selective inhibitor of Hepatitis C virus NS3/4a protease with broad activity across genotypes and resistant variants. Learn More -
GS-9256
Catalog No. A13526 HCV NS3 inhibitorGS-9451 is a potent macrocyclic HCV NS3 PI that achieved a median maximal change in HCV RNA of 3.6 log10 IU/mL (range, -4.7 log10 to -3.1 log10 IU/mL) following 3-day monotherapy in treatment-nave patients with HCV genotype 1 infection during phase I. Learn More -
BI207127 (Deleobuvir)
Catalog No. A13414 HCV NS5B polymerase inhibitorBI 207127 was a non-nucleoside hepatitis C virus NS5B polymerase inhibitor for the treatment of hepatitis C Learn More
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