MMP

Cat. No.

A76853

CAS No.

2787582-17-4

TP0556351

TP0556351 is a highly selective inhibitor of matrix metalloproteinase-2 (MMP2), exhibiting an IC50 value of 0.2 nM. This compound effectively decreases collagen accumulation in a murine model of Bleomycin-induced pulmonary fibrosis, making it a valuable tool for investigating idiopathic pulmonary fibrosis (IPF) and related fibrotic disorders. Researchers can utilize TP0556351 to explore the mechanisms of collagen turnover and therapeutic strategies targeting MMP2 in fibrotic diseases.

Cat. No.

A76854

CAS No.

261956-22-3

RO-28-2653

RO-28-2653 is an orally active inhibitor of matrix metalloproteinases (MMPs), specifically targeting MMP2, MMP9, and membrane-type 1-MMP. This compound exhibits selective inhibitory effects, potentially reducing side effects associated with broad-spectrum MMP inhibitors, such as musculoskeletal pain. In preclinical studies, RO-28-2653 has demonstrated significant tumor growth inhibition in rat models of prostate cancer, making it a valuable tool for research on hormone-sensitive tumors and related therapeutic applications.

Cat. No.

A76856

CAS No.

166245-54-1

OPB-3206

OPB-3206 is a selective matrix metalloproteinase (MMP) inhibitor that targets MMP-2, MMP-9, interstitial collagenase, and stromelysin with IC50 values of 7×10^-7 M, 5×10^-6 M, 5×10^-7 M, and 2×10^-6 M, respectively. By reversibly binding to the zinc-binding region of MMPs, OPB-3206 effectively prevents the activation of MMP-9, thereby reducing extracellular matrix degradation and inhibiting tumor lung metastasis. This compound shows promise for research focused on the metastatic behavior of osteosarcoma.

Cat. No.

A76857

CAS No.

333746-76-2

MMP-9-IN-7

MMP-9-IN-7 is a selective inhibitor of matrix metalloproteinase-9 (MMP-9) with an IC50 of 0.52 μM, as determined in the proMMP9/MMP3 P126 activation assay. This compound is sourced from patent WO2012162468 (example 59) and is suitable for investigating MMP-9 and MMP-13 mediated syndromes. Its potency and specificity make it a valuable tool in the study of MMP-associated pathologies and therapeutic research.

Cat. No.

A76858

CAS No.

106314-87-8

U27391

U27391 is a metalloproteinase inhibitor that specifically targets matrix metalloproteinases (MMPs). It is effective in inhibiting rhIL-1β induced proteoglycan loss, demonstrating its potential for research in cartilage degradation and inflammatory processes. U27391 is valuable for studies investigating osteoarthritis and other conditions associated with metalloproteinase activity.

Cat. No.

A76861

CAS No.

891198-38-2

Mca-Pro-Leu-Gly-Leu-Glu-Glu-Ala-Dap(Dnp)-NH2

Mca-Pro-Leu-Gly-Leu-Glu-Glu-Ala-Dap(Dnp)-NH2 is a highly selective substrate for matrix metalloproteinase 12 (MMP12), exhibiting a kcat/Km value of 1.85 x 10^5 M^-1s^-1. This compound shows limited activity against other matrix metalloproteinases, with notable kcat/Km values of 0.53 x 10^5 M^-1s^-1 for MMP13 and 0.33 x 10^5 M^-1s^-1 for MMP9. This selective profile makes it a useful tool for studying the role of MMP12 in biological processes and for potential therapeutic applications targeting MMP-related pathways.

Cat. No.

A76862

CAS No.

127033-74-3

(E)-N-(3-Methoxyphenyl)cinnamamide

(E)-N-(3-Methoxyphenyl)cinnamamide primarily targets the metalloproteinases MMP-2 and MMP-9, acting as a weakly selective inhibitor. It demonstrates inhibitory activity with IC50 values of 1674.81 nM for hMMP-2 and 1658.63 nM for hMMP-9, showing limited selectivity for MMP-1. This compound is relevant for cancer research, particularly in studies investigating tumor invasion and metastasis mediated by matrix metalloproteinases.

Cat. No.

A76863

CAS No.

179545-76-7

(Rac)-Tanomastat

Synonyms: (Rac)-BAY 12-9566

(Rac)-Tanomastat is a racemic mixture of the non-peptidic biphenyl compound Tanomastat, which functions as a selective inhibitor of matrix metalloproteinases (MMPs) through a zinc-binding carboxyl group. It exhibits Ki values of 11, 143, 301, and 1470 nM for MMP-2, MMP-3, MMP-9, and MMP-13, respectively. This compound demonstrates significant anti-invasive and antimetastatic properties in various experimental tumor models, making it a valuable tool for cancer research and therapeutic investigations focused on metastasis.

Cat. No.

A76864

CAS No.

87725-60-8

Smyrindiol

Synonyms: (2'S, 3'R)-3'-Hydroxymarmesin

Smyrindiol is an MMP-2 inhibitor derived from Dorstenia turbinate. This compound has demonstrated anti-inflammatory and antimicrobial properties through its ability to inhibit the secretion of tumor-associated proteases. Smyrindiol is applicable in research focused on brain tumors, including glioblastoma, providing insights into tumor biology and potential therapeutic strategies.

Cat. No.

A76866

CAS No.

3085676-77-0

MMP-9-IN-13

MMP-9-IN-13 is a potent and selective inhibitor of human matrix metalloproteinase 9 (MMP-9), exhibiting an IC50 value of 0.02 nM. This compound is valuable for studying the role of MMP-9 in ocular surface research, particularly in understanding its impact on tissue remodeling and inflammation. MMP-9-IN-13 can aid in elucidating the molecular mechanisms underlying various ocular conditions and potential therapeutic interventions.

Cat. No.

A76867

CAS No.

137530-61-1

BE-16627B

BE-16627B is a metalloproteinase inhibitor that exhibits potent activity in enzyme assays. Isolated from microbial cultures, this compound has demonstrated the ability to reduce the number and size of HT1080 cell nodules on the lung surface in murine models, as well as inhibit HT1080 cell growth in vivo. BE-16627B serves as a valuable tool for research in anti-cancer studies, particularly in understanding the role of metalloproteinases in tumor progression.

Cat. No.

A76868

CAS No.

2415311-84-9

MMP-2/9-IN-1

MMP-2/9-IN-1 is a potent dual inhibitor of matrix metalloproteinases MMP-2 and MMP-9, exhibiting IC50 values of 56 nM and 38 nM, respectively. This compound demonstrates significant anti-tumor activity by inhibiting tumor growth, promoting cancer cell apoptosis, and suppressing cell migration and cell cycle progression, which ultimately results in DNA fragmentation. MMP-2/9-IN-1 is valuable for research applications focused on cancer therapeutics and the underlying mechanisms of metastasis.

Cat. No.

A76870

CAS No.

120928-08-7

Pro-Leu-Gly-NHOH hydrochloride

Pro-Leu-Gly-NHOH hydrochloride is a selective inhibitor of matrix metalloproteinase-8 (MMP-8). It modulates extracellular matrix remodeling and has key implications in inflammatory processes and tissue repair. This reagent is useful in research applications involving the study of MMP-mediated pathways and their role in various diseases.

Cat. No.

A76875

CAS No.

906366-79-8

Inotilone

Inotilone is a selective inhibitor of matrix metalloproteinases MMP-2 and MMP-9, which are key enzymes involved in the metastatic progression of lung cancer. This compound enhances the activity of antioxidant enzymes, contributing to its anti-metastatic properties. Additionally, Inotilone inhibits IκBα phosphorylation and the nuclear translocation of NFκB p65, influencing various signaling pathways including FAK, PI3K/AKT, MAPKs, and NFκB. Inotilone is suitable for research applications focused on cancer metastasis and treatment strategies.

Cat. No.

A76879

CAS No.

2925249-49-4

MMP-13-IN-1

MMP-13-IN-1 is a potent and selective inhibitor of matrix metalloproteinase-13 (MMP-13), exhibiting an IC50 value of 16 nM. This compound demonstrates significant inhibitory activity, making it a valuable tool for studying the role of MMP-13 in various pathological processes, including atherosclerosis. Researchers can utilize MMP-13-IN-1 to explore its therapeutic potential in conditions related to extracellular matrix remodeling.

Cat. No.

A76880

CAS No.

514855-02-8

MMP13-IN-4

MMP13-IN-4 is a selective inhibitor of matrix metalloproteinase-13 (MMP-13) with an IC50 of 14.6 μM. This compound demonstrates significant activity in modulating the enzymatic activity associated with osteoarthritis (OA). MMP13-IN-4 is a valuable tool for research focused on understanding the role of MMP-13 in pathological conditions and developing therapeutic strategies for osteoarthritis.

Cat. No.

A76882

CAS No.

286845-00-9

ABT-518

ABT-518 is a matrix metalloproteinase (MMP) inhibitor that demonstrates significant anti-tumor activity. It exhibits potent inhibition of gelatinase A and B, which are key enzymes involved in tumor growth and metastasis. This compound is valuable for research focused on cancer biology, particularly in studies aimed at understanding and disrupting the metastatic process.

Cat. No.

A76885

CAS No.

883028-78-2

RJF02215

RJF02215 is an MMP-9 inhibitor that demonstrates growth-inhibitory activity on the ovarian cancer SKOV3 cell line. This compound is suitable for use in tumor research, allowing for studies on the role of matrix metalloproteinase-9 in cancer progression and therapy resistance. Its selective inhibition of MMP-9 may provide insights into the molecular mechanisms underlying ovarian cancer proliferation and metastasis.

Cat. No.

A76891

CAS No.

306733-22-2

F81-1144b

F81-1144b is an inhibitor of matrix metalloproteinases MMP-1 and MMP-3, exhibiting IC50 values of 5 nM and 29 nM, respectively. This compound effectively reduces serum and hepatic triacylglycerol levels, diminishes very-low-density lipoprotein-triacylglycerol secretion, and inhibits de novo hepatic fatty acid synthesis. Additionally, F81-1144b lowers serum insulin and glucose levels, making it a valuable reagent for research related to hypertriglyceridemia and metabolic disorders.

Cat. No.

A76892

CAS No.

1356992-21-6

XL-784 free base

XL-784 free base is a selective inhibitor of matrix metalloproteinases (MMPs), demonstrating potent inhibition with IC50 values of approximately 1900 nM for MMP-1, 0.81 nM for MMP-2, 120 nM for MMP-3, 10.8 nM for MMP-8, 18 nM for MMP-9, and 0.56 nM for MMP-13. This compound is essential for exploring the roles of MMPs in various biological processes including tissue remodeling, wound healing, and cancer metastasis. XL-784 free base can therefore serve as a valuable tool in pharmacological studies and drug development targeting MMP-related diseases.

Cat. No.

A76893

CAS No.

112105-54-1

RO314724

RO314724 is a selective inhibitor of matrix metalloproteinase-1 (MMP-1), targeting the catalytic zinc ion within its active site to form a stable complex. This compound exhibits potent biological activity in suppressing MMP-1 activity, making it a valuable tool for research into conditions such as osteoarthritis, where MMP-1 plays a significant role in tissue degradation.

Cat. No.

A76896

CAS No.

308824-37-5

SC-77964

SC-77964 is a potent and selective matrix metalloprotease (MMP) inhibitor with significant activity against MMP-2, MMP-9, and MMP-13, exhibiting IC50 values lower than 0.1 nM. This compound is effective for investigating mechanisms associated with cancer and inflammation, particularly in the context of melanoma research. Its orally active nature makes it a valuable tool for in vivo studies targeting MMP-related pathways.