Dopamine Receptors

Cat. No.

A70244

CAS No.

186204-32-0

Lurasidone Metabolite 14283 hydrochloride

Lurasidone Metabolite 14283 hydrochloride is a significant active metabolite of the antipsychotic agent Lurasidone, which targets serotonin and dopamine receptors. This compound plays a crucial role in the pharmacological activity of Lurasidone, contributing to its efficacy in the treatment of schizophrenia. Research applications include studying the metabolic profile of Lurasidone and its pharmacodynamics in neural systems.

Cat. No.

A70305

CAS No.

2448341-72-6

Quetiapine sulfoxide hydrochloride

Synonyms: Quetiapine S-oxide hydrochloride

Quetiapine sulfoxide hydrochloride is a primary metabolite of Quetiapine, a second-generation antipsychotic. This compound acts primarily as a 5-HT receptor agonist and dopamine receptor antagonist, contributing to the pharmacological profile of Quetiapine. It is valuable in research focusing on the metabolism and pharmacokinetics of antipsychotic medications, providing insights into their therapeutic effects and potential side effects.

Cat. No.

A70572

CAS No.

139079-39-3

7-Hydroxyquetiapine

Synonyms: ICI 214227

7-Hydroxyquetiapine is the primary active metabolite of the antipsychotic agent Quetiapine. It functions by modulating various neurotransmitter systems, particularly serotonin and dopamine receptors, contributing to its therapeutic effects in managing psychiatric disorders. This compound is valuable for studying the pharmacological profile of Quetiapine and investigating its metabolic pathways in both in vitro and in vivo research settings.

Cat. No.

A70768

CAS No.

1330238-38-4

Quetiapine Sulfoxide-d8

Quetiapine Sulfoxide-d8 is a deuterated analog of Quetiapine sulfoxide, a primary metabolite of the second-generation antipsychotic Quetiapine. This compound acts as a 5-HT receptor agonist and dopamine receptor antagonist, playing a critical role in the pharmacokinetic studies of Quetiapine metabolism. Quetiapine Sulfoxide-d8 is commonly utilized in research applications involving drug metabolism, pharmacology, and analytical chemistry, particularly in the development and validation of quantitation methods in biological samples.

Cat. No.

A70795

CAS No.

72822-03-8

Pergolide sulfone

Pergolide sulfone is a metabolite of Pergolide, primarily acting as a dopamine receptor agonist. This compound exhibits significant dopaminergic activity, making it relevant for research into Parkinson's disease and other neurological disorders. Pergolide sulfone can be utilized in studies investigating the pharmacological profiles of dopamine receptor interactions and their implications in neurodegenerative conditions.

Cat. No.

A70887

CAS No.

34104-67-1

Reduced Haloperidol

Synonyms: Haloperidol metabolite II

Reduced Haloperidol, a primary metabolite of Haloperidol, functions as a dopamine receptor antagonist. It exhibits significant antipsychotic activity, primarily utilized in research related to schizophrenia and other psychotic disorders. This compound is instrumental in studies investigating the modulation of neurotransmitter systems, aiding in the reduction of hallucinations and delusions associated with these conditions.

Cat. No.

A72397

CAS No.

161696-76-0

N-Desmethylolanzapine

Synonyms: N-Demethylolanzapine; LY170055

N-Desmethylolanzapine is an active metabolite of the antipsychotic agent olanzapine, primarily targeting dopamine D2 and serotonin 5-HT2A receptors. This compound’s formation is influenced by the activity of human liver flavin-containing monooxygenase 3 (FMO3), making it important for understanding drug metabolism. N-Desmethylolanzapine is utilized in research on antipsychotic drugs, aiding in studies of pharmacological effects and metabolic pathways associated with psychiatric disorders.

Cat. No.

A73718

CAS No.

109453-73-8

Bmapn

Bmapn is a drug derivative with impactful interactions on dopamine signaling pathways. It exhibits rewarding and reinforcing properties by decreasing dopamine transporter levels and enhancing dopamine receptor D2 gene expression specifically in the striatum. This compound is valuable for research applications studying addiction, neuropharmacology, and the modulation of dopaminergic systems.

Cat. No.

A73719

CAS No.

201740-80-9

Boc-Leu-OH·H2O-13C

Boc-Leu-OH·H2O-13C is a stable isotope-labeled derivative of N-Boc-L-leucine, featuring a carbon-13 (13C) label. This amino acid derivative, protected with a Boc group, serves as an essential building block for the synthesis of peptides, such as L-prolyl-L-leucyl-glycinamide, which exhibit modulatory activity on dopamine receptors. It is valuable for applications in peptide research, metabolic studies, and tracer experiments utilizing stable isotopes.

Cat. No.

A75310

CAS No.

7287-19-6

Prometryn

Prometryn is a herbicide that primarily inhibits photosynthesis by targeting the D1 protein in photosystem II. This compound demonstrates significant biological activity in controlling a wide range of weed species, thereby enhancing agricultural productivity. Prometryn is commonly utilized in research applications focused on weed management and crop yield optimization.

Cat. No.

A78222

CAS No.

70801-02-4

Flutroline

Synonyms: CP-36584

Flutroline is an orally active tetrahydro-7-carboline compound that functions as an antipsychotic agent. It exhibits significant potency in modulating neurotransmitter systems, making it a valuable tool for investigating the mechanisms underlying psychiatric disorders. Its primary applications include research into the pharmacological pathways influencing psychosis and the development of novel antipsychotic therapies.

Cat. No.

A78910

CAS No.

1627576-64-0

JJC8-089

JJC8-089 is a selective dopamine transporter (DAT) inhibitor that enhances motivational behaviors and promotes engagement in goal-directed tasks. Research has demonstrated that JJC8-089 effectively counteracts the low-effort behavior induced by the VMAT-2 inhibitor Tetrabenazine in rat models, leading to a marked preference for high-effort tasks over free access to food. This compound serves as a valuable tool for investigating dopamine-related behavioral mechanisms and motivational dysfunction.

Cat. No.

A85996

CAS No.

200936-87-4

Boc-Leu-OH hydrate

Synonyms: N-Boc-L-leucine monohydrate

Boc-Leu-OH hydrate (N-Boc-L-leucine monohydrate) is a protected form of the amino acid leucine, featuring a Boc protecting group. It serves as a useful intermediate in peptide synthesis, particularly for the generation of L-prolyl-L-leucyl-glycinamide, a peptide mimetic known for its modulatory effects on dopamine receptors. This compound is valuable in research focused on neuropharmacology and peptide therapeutics.

Cat. No.

A89414

CAS No.

54690-19-6

α-ethyl 2C-D hydrochloride

Synonyms: BL-3912; alpha-EH DOM

α-Ethyl 2C-D hydrochloride is a phenethylamine derivative that acts primarily on serotonin and dopamine receptors. This compound exhibits significant psychoactive properties and has been utilized in research to explore the effects of amphetamines and their analogs. It serves as a reference standard in drug discrimination studies, particularly for understanding the pharmacological profiles of MDMA.

Cat. No.

A90112

CAS No.

76716-60-4

Fluprazine

Fluprazine is an anxiolytic compound that primarily targets neurotransmitter systems to alleviate anxiety symptoms. This compound exhibits key biological activity in modulating serotonin and dopamine receptors, making it relevant in the study of various psychiatric disorders. Researchers utilize Fluprazine for investigating therapeutic approaches in anxiety and related mood disorders.

Cat. No.

A92533

CAS No.

26964-71-6

Fenaperone hydrochloride

Fenaperone hydrochloride is a neuroleptic agent that primarily targets dopamine receptors in the central nervous system. It exhibits antipsychotic properties, making it relevant for research in neurological disorders and psychiatric conditions. Its mechanism includes modulation of neurotransmitter activity, contributing to its potential therapeutic effects in various mental health applications.

Cat. No.

A94612

CAS No.

62030-88-0

Duoperone

Duoperone is a neuroleptic agent that acts primarily by antagonizing dopamine receptors. This compound exhibits significant antiemetic properties in various animal models, making it valuable for studies related to nausea and psychotic disorders. Its applications extend to biochemical assays that investigate neurotransmitter dynamics and the pharmacological evaluation of antipsychotic drugs.

Cat. No.

A95090

CAS No.

70500-72-0

7-Hydroxycarbostyril

Synonyms: 7-Hydroxyquinolinone; 2,7-Dihydroxyquinoline

7-Hydroxycarbostyril, a quinolinone derivative, serves as a valuable intermediate in the synthesis of Brexpiprazole, a widely studied antipsychotic agent. Brexpiprazole functions as a partial agonist at the human 5-HT1A and dopamine D2L receptors, contributing to its therapeutic effects in the treatment of psychiatric disorders. This compound is instrumental for researchers investigating antipsychotic mechanisms and developing novel therapeutic agents.

Cat. No.

A95132

CAS No.

1227293-15-3

N-Acetyl-3,4-MDMC

N-Acetyl-3,4-MDMC is a drug derivative structurally related to 3,4-methylenedioxymethcathinone. This compound has been investigated for its psychoactive properties and potential interactions with monoamine transporters, particularly serotonin and dopamine receptors. Research applications include studies on its effects on neural activity and behavioral responses in various models of neurotransmission.

Cat. No.

A95639

CAS No.

7009-43-0

Methiomeprazine

Methiomeprazine is a drug derivative primarily targeting the dopaminergic system. It exhibits significant antipsychotic and sedative properties, making it valuable in the treatment of various psychiatric disorders. Methiomeprazine is commonly used in research related to neuropharmacology and the exploration of dopamine receptor interactions. Its efficacy in managing behavioral symptoms also positions it as a candidate for studies on mental health therapies.

Cat. No.

A95959

CAS No.

5800-19-1

Metiapine

Metiapine is an antipsychotic agent and a derivative of dibenzothiazepine. It primarily acts by modulating neurotransmitter systems associated with psychotic disorders. Metiapine has been shown to decrease food consumption, making it relevant in studies of appetite regulation and schizophrenia research. Its unique mechanism offers insights into the treatment of psychiatric conditions and the neural pathways involved.

Cat. No.

A96005

CAS No.

3565-47-7

R-1647

R-1647 is a haloperidol derivative targeting neurotransmitter systems associated with psychotic disorders. This compound demonstrates significant antipsychotic activity and is utilized in research to investigate mechanisms underlying schizophrenia and related conditions. Its pharmacological profile makes it an important tool for studying the efficacy and safety of novel antipsychotic therapies.

Cat. No.

A96024

CAS No.

99234-87-4

SKF 83692

SKF 83692 is a potent derivative that primarily targets dopamine receptors, specifically D1-like receptors. This compound exhibits notable biological activity in modulating dopaminergic signaling, making it valuable for research in neuropharmacology and the study of dopamine-related disorders. SKF 83692 serves as an important tool for investigating receptor pharmacology and the potential therapeutic effects of dopamine modulation in various neurological conditions.

Cat. No.

A96287

CAS No.

1823776-22-2

5-EAPB hydrochloride

5-EAPB hydrochloride is a benzofuran derivative that acts primarily as a serotonin and dopamine receptor modulator. This compound is known for its psychoactive properties and has been used in neurological research to explore the mechanisms of mood regulation and cognitive function. Its ability to enhance serotonergic transmission makes it a valuable tool for studying various neuropharmacological applications.

Cat. No.

A97010

CAS No.

2975-34-0

Carphenazine dimaleate

Carphenazine dimaleate is an antipsychotic agent belonging to the phenothiazine class. It primarily functions by antagonizing dopamine D2 receptors, making it effective in modulating symptoms of psychosis. This compound is utilized in research focused on chronic schizophrenia and related neuropsychiatric disorders, providing insights into therapeutic approaches for managing these conditions.