Dopamine Receptors

Cat. No.

A60218

CAS No.

117591-79-4

(S)-Remoxipride hydrochloride hydrate

Synonyms: (-)-Remoxipride hydrochloride hydrate

(S)-Remoxipride hydrochloride hydrate is a selective antagonist of the dopamine D2 receptor, exhibiting an IC50 value of 1.57 μM. This compound is primarily utilized in the study of psychotic disorders, providing a valuable tool for understanding the mechanisms underlying dopamine-related pathologies and developing therapeutic strategies. Its specificity for the D2 receptor makes it an important reagent in neuropharmacology research.

Cat. No.

A60219

CAS No.

59831-64-0

Milenperone

Milenperone is a potent dopamine antagonist that primarily targets dopamine receptors. Its biological activity allows for the modulation of dopaminergic signaling, making it valuable in research focusing on neurological disorders. Milenperone is particularly useful in studies investigating the mechanisms underlying conditions related to dopamine dysregulation.

Cat. No.

A60220

CAS No.

2446466-62-0

4-EEC hydrochloride

4-EEC hydrochloride is a synthetic stimulant that acts as a releasing agent for norepinephrine and dopamine. It exhibits neurochemical properties that can influence mood and cognitive function. This compound is primarily used in research applications related to neuropharmacology and the study of stimulant drugs.

Cat. No.

A60221

CAS No.

329218-14-6

Desethoxy Quetiapine dihydrochloride

Desethoxy Quetiapine dihydrochloride is a selective antagonist of the dopamine D2 receptor, exhibiting an IC50 value of 1330 nM. This compound effectively inhibits Apomorphine-induced climbing and swimming behavior in murine models, making it valuable for investigating neuropharmacological activity and the modulation of dopaminergic signaling. Its utility in behavioral studies supports research into the therapeutic effects of D2 receptor antagonism in psychiatric disorders.

Cat. No.

A60222

CAS No.

90955-43-4

SKF 83509

SKF 83509 is a selective dopamine D1 antagonist with a Ki value of 70.2 nM, demonstrating no activity at dopamine D2 receptors. This compound is primarily utilized in neuropharmacological research to investigate the role of dopamine D1 receptors in various neurological conditions. SKF 83509 aids in the exploration of dopaminergic signaling pathways and contributes to studies focused on drug addiction, schizophrenia, and other dopamine-related disorders.

Cat. No.

A60223

CAS No.

170857-36-0

Sonepiprazole hydrochloride

Synonyms: PNU-101387G hydrochloride; U-101387G hydrochloride

Sonepiprazole hydrochloride is a selective antagonist of the D4 dopamine receptor, exhibiting Ki values of 3.6 nM for the rat D4 dopamine receptor and 10.1 nM for the human D4.2 dopamine receptor. This compound demonstrates significant selectivity, with much higher Ki values of 5147 nM and 7430 nM for the rat D2 dopamine and Histamine H1 receptors, respectively. Sonepiprazole hydrochloride is useful for investigating the role of D4 receptors in neurological disorders and may have applications in psychopharmacology research.

Cat. No.

A60224

CAS No.

102671-35-2

FR 64822

FR 64822 is a potent dopamine D2 receptor agonist that demonstrates significant antinociceptive activity in preclinical models, such as rats and mice, via indirect stimulation of these receptors. In addition to its analgesic properties, FR 64822 has been shown to facilitate penile erection in juvenile rats and mitigate scopolamine-induced amnesia during passive avoidance tasks. Its diverse biological activities make it a valuable tool for research in neuropharmacology and behavioral studies.

Cat. No.

A60225

CAS No.

95999-12-5

(+)-UH 232 (UH 232)

Synonyms: UH 232

(+)-UH 232 is a partially selective agonist of the D3 dopamine receptor, exhibiting an intrinsic activity of 0.2-0.4. This compound effectively antagonizes quinpirole-induced mitogenesis, with a reported Ki value of 9.4 nM. It is utilized in research to explore D3 receptor signaling and its implications in various neurobiological processes.

Cat. No.

A60226

CAS No.

36504-93-5

Butaclamol

Butaclamol is an antipsychotic agent that functions primarily as a D2 dopamine receptor antagonist. This compound exhibits significant neuroleptic activity, making it a valuable tool in the study of psychotic disorders. It is utilized in research to explore the mechanisms underlying dopaminergic signaling and its implications in various neuropsychiatric conditions.

Cat. No.

A60227

CAS No.

3109-12-4

Deschlorohaloperidol

Synonyms: R-1838

Deschlorohaloperidol is a potent analogue of Haloperidol, primarily acting as a dopamine D2 receptor (D2R) antagonist. This compound exhibits significant antipsychotic activity, making it valuable in research focused on schizophrenia and related disorders. Its structural modifications enhance its efficacy for investigating dopamine signaling pathways and therapeutic interventions in psychiatric conditions.

Cat. No.

A60228

CAS No.

224170-09-6

U-101958 maleate

Synonyms: PNU-101958 maleate

U-101958 maleate is a highly selective antagonist for the dopamine D4 receptor, exhibiting an IC50 of 2.7 nM. In HEK-293 cells expressing the human recombinant D4.4 receptor, U-101958 behaves as an agonist, demonstrating its versatile interaction with this target. This compound is primarily utilized in research related to antipsychotic effects and the modulation of dopaminergic signaling pathways.

Cat. No.

A60229

CAS No.

871351-61-0

Ordopidine hydrochloride

Synonyms: ACR-325 hydrochloride

Ordopidine hydrochloride is a modulator of dopamine receptors that demonstrates an ED50 of 68 μmol/kg for increasing DOPAC levels in the rat striatum. This compound is valuable in research applications focused on neurological disorders and dopamine-related signaling pathways. Its ability to influence dopamine metabolism makes it a useful tool for exploring the role of dopamine in various physiological and pathological conditions.

Cat. No.

A60230

CAS No.

710655-15-5

PF-592379

PF-592379 is a selective agonist of the dopamine D3 receptor, exhibiting an EC50 of 21 nM. This compound demonstrates significant potential in modulating dopaminergic signaling pathways, making it valuable for research applications related to neuroinflammatory disorders and addiction. Its ability to influence dopamine receptor activity makes PF-592379 a useful tool for studying the role of dopamine in various physiological and pathological processes.

Cat. No.

A60231

CAS No.

108226-05-7

Benzamide Derivative 1

Benzamide Derivative 1 is a dopamine receptor antagonist with potential applications in the treatment of gastrointestinal disorders. This compound, derived from patent EP0213775A1, compound 18, exhibits key biological activity by modulating dopamine signaling pathways. Its role in gastrointestinal function makes it a valuable tool for researchers investigating the interplay between dopamine receptors and gut health.

Cat. No.

A60232

CAS No.

152886-85-6

U91356

U91356 is a selective dopamine receptor agonist that targets D1-like receptors. This compound has been shown to enhance dopaminergic signaling, making it useful in studies investigating neurological disorders such as schizophrenia and Parkinson's disease. U91356 facilitates the exploration of dopamine-related pathways and receptor interactions in various biological systems.

Cat. No.

A66204

CAS No.

2517420-92-5

(Rac)-NNC 55-0396

(Rac)-NNC 55-0396 is a racemic mixture that targets the dopamine D2 receptor. This compound is of significant interest in neurological research due to its potential role in modulating dopaminergic signaling pathways. It is commonly utilized in studies investigating the pharmacological effects of dopamine receptor antagonists in various neurological disorders.

Cat. No.

A66684

CAS No.

53786-28-0

R 29676

R 29676 is a neuroleptic agent that inhibits sodium-dependent GABA binding, effectively modulating GABA uptake. This compound has demonstrated significant potential in research related to neuropharmacology and the treatment of various neuropsychiatric disorders. Its ability to influence GABAergic signaling makes it a valuable tool for studying the mechanisms underlying anxiety and mood regulation.

Cat. No.

A67415

CAS No.

5611-64-3

Methalthiazide

Methalthiazide is an antipsychotic agent that enhances the activity of natural stimulators of AMPA receptors. Its primary mechanism involves modulating glutamatergic signaling, making it a valuable tool in schizophrenia research. This compound can be utilized to explore the underlying mechanisms of psychotic disorders and assess potential therapeutic strategies.

Cat. No.

A68116

CAS No.

5169-78-8

Tipepidine

Tipepidine is an inhibitor of the dopamine D2 receptor-mediated G-protein coupled inwardly rectifying potassium (GIRK) currents, exhibiting a half-maximal inhibitory concentration (IC50) of 7.0 μM. By inhibiting these currents, Tipepidine activates ventral tegmental area (VTA) dopamine neurons, thereby influencing dopaminergic signaling. This compound has demonstrated potential antidepressant-like effects and is commonly studied in research related to neuropharmacology and respiratory conditions.

Cat. No.

A68567

CAS No.

693765-11-6

(Z)-Flunarizine

(Z)-Flunarizine is the (Z)-isomer of Flunarizine, a potent dual blocker of Na+/Ca2+ channels, specifically targeting T-type calcium channels. This compound exhibits significant anticonvulsant and antimigraine properties, as well as peripheral vasodilatory effects. It is utilized in research applications focused on neuropharmacology and cardiovascular studies.

Cat. No.

A70055

CAS No.

95333-81-6

SKF-102698

SKF-102698 is an inhibitor of dopamine β-hydroxylase, a key enzyme in catecholamine biosynthesis. By inhibiting this enzyme, SKF-102698 effectively increases endogenous dopamine levels, providing valuable insights into dopaminergic signaling. This compound is particularly useful in hypertension research, allowing for the exploration of dopamine’s role in blood pressure regulation and cardiovascular health.

Cat. No.

A70056

CAS No.

14901-16-7

U-14624

U-14624 is a potent inhibitor of dopamine beta-hydroxylase, exhibiting strong oral bioavailability. This compound effectively suppresses the enzymatic activities of aminopyrine N-demethylase, aniline hydroxylase, and p-nitroanisole O-demethylase. U-14624 is valuable for research applications focusing on neuropharmacology and the regulation of dopamine levels.

Cat. No.

A70060

CAS No.

22632-06-0

Bupicomide

Bupicomide is a selective inhibitor of dopamine beta-monooxygenase, functioning through the mechanism analogous to fusaric acid. This compound has demonstrated utility in the study of hypertension, making it a valuable tool for research on neurochemical pathways related to blood pressure regulation and cardiovascular health.

Cat. No.

A70062

CAS No.

1446-24-8

3-Allylphenol

3-Allylphenol is a potent inhibitor of dopamine β-hydroxylase, demonstrating a Ki value of 12 mM. This compound is essential for studying the regulation of catecholamine synthesis and can be utilized in research applications aimed at understanding neurotransmitter dynamics and related physiological processes.

Cat. No.

A70165

CAS No.

329218-11-3

Quetiapine sulfoxide dihydrochloride

Synonyms: Quetiapine S-oxide dihydrochloride

Quetiapine sulfoxide dihydrochloride is a primary metabolite of the second-generation antipsychotic quetiapine. This compound functions as a 5-HT receptor agonist and a dopamine receptor antagonist, contributing to its pharmacological effects. It is commonly utilized in research related to neuropharmacology and metabolic profiling of antipsychotic drugs, offering insights into the drug's therapeutic activity and safety profile.