Dopamine Receptors

Cat. No.

A60191

CAS No.

757176-96-8

Dinoxyline

Dinoxyline is a potent agonist of dopamine receptors, exhibiting high affinity with Ki values of 7 nM, 6 nM, 5 nM, and 43 nM for D1, D2, D3, and D4 receptors, respectively. This compound is valuable for investigating dopaminergic signaling pathways and their implications in neurological research. Its ability to selectively engage dopamine receptors makes it an essential tool for studies related to mood disorders, addiction, and other neurological conditions.

Cat. No.

A60192

CAS No.

410074-73-6

Amitifadine

Synonyms: DOV-21947; EB-1010

Amitifadine is a serotonin-norepinephrine-dopamine reuptake inhibitor (SNDRI) that targets the dopamine transporter (DAT), norepinephrine transporter (NET), and serotonin transporter (SERT). It exhibits inhibitory concentrations of 12 nM for serotonin, 23 nM for norepinephrine, and 96 nM for dopamine in HEK 293 cells. This compound is pertinent for research applications exploring the modulation of monoaminergic systems and investigating potential therapeutic effects in mood disorders.

Cat. No.

A60193

CAS No.

1953181-29-7

BRD5814

BRD5814 is a potent antagonist of the dopamine D2 receptor (D2R), a key target in the modulation of dopaminergic signaling. This compound demonstrates significant inhibitory activity, making it a valuable tool in research focused on schizophrenia and other neuropsychiatric disorders. Its application in studies of D2R-related pathways can aid in understanding the complex mechanisms underlying these conditions.

Cat. No.

A60194

CAS No.

562104-72-7

FAUC-312

FAUC-312 is a tetrahydropyrimidine that acts as a selective partial agonist of the dopamine D4 receptor, exhibiting a Ki value of 1.5 nM. This compound modulates dopaminergic signaling and has potential applications in researching neuropsychiatric disorders, including schizophrenia and attention deficit hyperactivity disorder (ADHD). Its specificity towards the D4 receptor allows for the exploration of receptor-specific pathways and therapeutic interventions.

Cat. No.

A60195

CAS No.

51938-11-5

7-Hydroxychlorpromazine hydrochloride

7-Hydroxychlorpromazine hydrochloride is the active metabolite of Chlorpromazine, primarily targeting dopamine receptors. This compound is known to increase prolactin levels and enhance dopamine turnover, exhibiting notable sedative effects. Research applications include studying psychosis and investigating its efficacy in inhibiting amphetamine-induced stereotyped behaviors in rodent models.

Cat. No.

A60196

CAS No.

108351-90-2

PD 118440

PD 118440 is an orally active dopamine agonist that targets dopaminergic signaling pathways within the central nervous system. This compound demonstrates notable biological activity by inhibiting striatal dopamine synthesis and suppressing the firing of dopamine neurons. Additionally, PD 118440 has been shown to reverse Reserpine-induced depression in rodent models, making it a valuable tool for research in neuropharmacology and mood disorder studies.

Cat. No.

A60197

CAS No.

51473-23-5

Lergotrile mesylate

Lergotrile mesylate is a potent orally active dopamine agonist that functions primarily by activating dopamine receptors in the adenohypophysis, thereby inhibiting prolactin secretion. This mechanism contributes to its potential applications in the research of Parkinson's disease and related disorders. By modulating dopamine activity, Lergotrile mesylate serves as a valuable tool for exploring therapeutics targeting dopaminergic pathways.

Cat. No.

A60198

CAS No.

59032-40-5

Disulergine

Synonyms: CH 29-717

Disulergine is an ergot alkaloid that acts as a dopamine receptor agonist. It has been shown to inhibit prolactin secretion in rats and also suppress the release of growth hormone (GH). This compound is particularly relevant for research applications exploring the regulation of hormonal pathways and the physiological effects of dopamine receptor modulation.

Cat. No.

A60199

CAS No.

69082-47-9

Brl 20596

Brl 20596 is a potent central dopamine receptor antagonist. This compound exhibits significant inhibitory activity at dopamine receptors, making it valuable for antipsychotic research. Its ability to modulate dopaminergic signaling can aid in the investigation of neuropsychiatric disorders related to dopamine dysregulation.

Cat. No.

A60200

CAS No.

81654-57-1

7-Hydroxy ropinirole bromide

Synonyms: SK&F 89124 bromide

7-Hydroxy ropinirole bromide is a selective DA2 receptor agonist that demonstrates significant inhibitory effects on neurotransmitter release and sympathetic nerve responses. This compound, a derivative of N,N-di-n-propyldopamine (DPDA), has shown promise in isolated perfused rabbit ear artery models, making it a valuable tool for studying cardiovascular and neurological disorders. Its targeted mechanism of action underscores its relevance in exploring therapeutic interventions in these fields.

Cat. No.

A60201

CAS No.

163239-24-5

PD-147693

PD-147693 is the active metabolite of the presynaptic dopamine autoreceptor agonist CI-1007, exhibiting antipsychotic activity akin to its parent compound. This reagent is utilized in neuropharmacological research to explore the mechanisms of dopaminergic signaling and evaluate potential therapeutic approaches for neuropsychiatric disorders. Its relevance extends to studies focused on dopamine receptor interactions and their implications in psychopharmacology.

Cat. No.

A60202

CAS No.

175442-95-2

(Rac)-GR218231

(Rac)-GR218231 is a selective antagonist of the dopamine D3 receptor, exhibiting a pKi value of 8.9. This compound is valuable for studying the role of D3 receptors in various neurological and psychiatric disorders. Its pharmacological properties make it an important tool for research into dopamine-related pathways and potential therapeutic interventions.

Cat. No.

A60203

CAS No.

61955-05-3

A 23887

A 23887 is a semirigid antipsychotic compound that primarily targets the dopamine D2 receptor. It exhibits significant affinity for this receptor, which is crucial for modulating dopaminergic signaling pathways. This compound is primarily utilized in research related to psychiatric disorders, particularly in the study of schizophrenia and other neuropsychiatric conditions.

Cat. No.

A60205

CAS No.

1329611-00-8

Ropinirole-d3 hydrochloride

Synonyms: SKF 101468-d3 hydrochloride

Ropinirole-d3 hydrochloride is a deuterium-labeled derivative of Ropinirole hydrochloride, functioning as a potent agonist for D2 and D3 dopamine receptors, with a Ki value of 29 nM for the D2 receptor. It exhibits pEC50 values of 7.4, 8.4, and 6.8 for human D2, D3, and D4 receptors, respectively, while showing no affinity for D1 receptors. This compound is primarily utilized in research related to dopamine receptor signaling and has potential implications for therapies targeting Parkinson's disease.

Cat. No.

A60206

CAS No.

138559-56-5

ADR 851 free base

ADR 851 free base is a potent antagonist of the dopamine D2 receptor, making it valuable for research applications focused on antiemetic effects. This compound demonstrates significant potential in modulating dopamine-related pathways, contributing to the understanding of various neurological and psychiatric disorders. Its utilization in experimental studies may provide insights into therapeutic strategies targeting nausea and vomiting.

Cat. No.

A60208

CAS No.

71636-62-9

SKF-80723

SKF-80723 acts as a selective agonist for the dopamine D1 receptor, playing a crucial role in neurotransmitter signaling. This compound is primarily utilized in neuroscience research, particularly in studies related to Parkinson's disease and dopaminergic dysfunction. Its activation of D1 receptors offers insights into potential therapeutic strategies for neurodegenerative conditions associated with dopaminergic signaling deficits.

Cat. No.

A60209

CAS No.

189681-71-8

Aplindore fumarate

Synonyms: DAB-452 fumarate

Aplindore fumarate is a partial agonist of the dopamine D2 receptor, primarily utilized in neurological research. This compound has shown potential in studies related to Parkinson's disease and schizophrenia, offering insights into dopaminergic signaling pathways. Its activity makes it a valuable tool for investigating therapeutic strategies and understanding the underlying mechanisms of these disorders.

Cat. No.

A60210

CAS No.

159559-71-4

7-Hydroxy-PIPAT

7-Hydroxy-PIPAT is a selective agonist of the D3 dopamine receptor, exhibiting a high binding affinity with a Ki value of 0.99 nM. This compound is utilized in research to explore mechanisms related to dopaminergic signaling and may offer insights into the pathology of neuropsychiatric disorders. Its potent activity makes it a valuable tool for studying D3 receptor-mediated pathways in various biological contexts.

Cat. No.

A60211

CAS No.

57359-17-8

S3608

S3608 is an atypical dopamine agonist that selectively activates dopamine receptors, contributing to enhanced locomotor activity. This compound has been shown to dose-dependently increase locomotor activity in rodent models, making it a valuable tool for studying dopaminergic signaling and its implications in neuropharmacology. S3608 can be utilized in research applications focused on movement disorders, addiction, and behavioral studies related to dopamine modulation.

Cat. No.

A60212

CAS No.

170858-34-1

Sonepiprazole mesylate

Synonyms: PNU-101387G mesylate; U-101387G mesylate

Sonepiprazole mesylate is a selective D4 dopamine receptor antagonist that exhibits inhibition constants (Kis) of 3.6 nM for rD4-Dopamine and 10.1 nM for hD4.2-Dopamine, indicating potent activity at these targets. Additionally, it shows significantly lower affinity for rD2-Dopamine (5147 nM) and Histamine-H1 receptors (7430 nM). This compound is valuable for research applications focused on neurobiology, particularly in studies related to dopamine receptor signaling and its implications in psychiatric disorders.

Cat. No.

A60213

CAS No.

69319-52-4

A31472

A31472 is a potent antagonist of dopamine D-2 receptors, making it a valuable tool for studying the pharmacology of antipsychotic agents. Its mechanism of action is critical for exploring the underlying pathways associated with dopamine dysregulation. Researchers can utilize A31472 to investigate its effects on behavioral and neurochemical processes relevant to psychiatric disorders.

Cat. No.

A60214

CAS No.

4177-58-6

Clothixamide

Synonyms: Clotixamide

Clothixamide is a dopamine antagonist that primarily targets dopamine receptors in the central nervous system. It exhibits biological activity relevant to the modulation of dopaminergic signaling and is useful for investigating various psychiatric disorders, including schizophrenia and depression. Research applications include studying the effects of dopamine inhibition on behavior and neurotransmitter pathways.

Cat. No.

A60215

CAS No.

83507-02-2

Org-10490

Org-10490 is a potent antagonist of dopamine D1 and D2 receptors, primarily utilized in neurological and psychiatric research. It plays a critical role in studies related to disorders such as schizophrenia and bipolar disorder by modulating dopaminergic signaling pathways. Its efficacy in receptor inhibition makes Org-10490 valuable for investigating therapeutic strategies targeting dopamine-related conditions.

Cat. No.

A60216

CAS No.

327026-93-7

Lensiprazine

Lensiprazine is a potent dopamine D2 receptor antagonist that also functions as a serotonin reuptake inhibitor. This compound is primarily utilized in research focusing on psychiatric disorders, including bipolar disorder and schizophrenia, facilitating the exploration of neurochemical pathways involved in these conditions. Its dual action provides valuable insights into the modulation of neurotransmitter systems.

Cat. No.

A60217

CAS No.

79262-47-8

Savoxepin mesylate

Savoxepin mesylate is a selective antagonist of the D2 dopamine receptor, exhibiting antipsychotic properties. It specifically targets dopamine D2 receptors in the hippocampus while sparing those in the striatum, thereby minimizing the likelihood of extrapyramidal side effects. This selective action makes Savoxepin mesylate a valuable tool for research addressing dopaminergic signaling and its implications in neuropsychiatric disorders.