Prostanoid Receptors

OBE022 is an oral and selective prostaglandin F2α (PGF2α) receptor antagonist, with Kis of 1 nM, 26 nM for human and rat FP receptors, respectively.

E7046 is an orally bioavailable and specific EP4 antagonist, with IC50 of 13.5 nM and Ki of 23.14 nM, exhibiting anti-tumor activities.

CRTh2 antagonist 1 is a CRTh2 antagonist with an IC50 of 89 nM.

Tiaprost is a prostaglandin F2α (PGF2α) analogue.

LCB-2853 is an antagonist of thromboxane A2 (TXA2) receptor, with antiplatelet and antithrombotic activities.

EP1-antanoist-1 is a EP1 antagonist with a pKi of 7.54 and an pIC50 of 8.5.

AZ-1355 is an effctive lipid-lowering compound, which also inhibits platelet aggregation in vivo and elevates the prostaglandin I2/thromboxane A2 ratio in vitro.

MK-8318 is a potent and selective CRTh2 receptor antagonist with a Ki of 5.0 nM.

GSK726701A is a novel prostaglandin E2 receptor 4 (EP4) partial agonist with a pEC50 of 7.4.

PGD2-IN-1 is an antagonist of DP extracted from patent WO 2006044732 A2, example 15 (d); has an IC50 of 0.3 nM.

CAY10595 is a potent CRTH2/DP2 receptor antagonist that binds to the human receptor with a Ki of 10 nM.

BI-671800 is a CRTH2 antagonist that treats patients with asthma.

L 888607 is a potent, and selective CRTH2 (also known as DP2) agonist with a Ki of 0.8 nM.

Carbacyclin is a PGI2 analogue, acts as a prostacyclin (PGI2) receptor agonist and vasodilator, and potently inhibits platelet aggregation.

BAY-1316957 is a highly potent and selective EP4 receptor antagonist with an IC50 of 15.3 nM. Good oral bioavailability.

Saikosaponin B2 is a saponin activator.

GW627368 is a novel, potent and selective competitive antagonist of prostanoid EP4 receptor(Ki= 100 nM) with additional human TP receptor affinity(Ki= 150 nM).

MF498 is a novel and selective E prostanoid receptor 4 (EP4 receptor) antagonist, displayed strong binding affinity for the EP4 receptor with Ki of 0.7 nM,

Fenprostalene is a potent analog of prostaglandin F2α (PGF2α) that primarily targets the prostaglandin pathway. This compound is effective in veterinary medicine for inducing corpus luteum regression and lowering blood progesterone levels in dogs. Its primary applications include the treatment of pyometra and the induction of abortion, making it a critical reagent in reproductive health studies and veterinary practices.