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Autotaxin (ENPP2)

Autotaxin inhibitors act on the secreted enzyme that produces the lipid mediator lysophosphatidic acid (LPA). Autotaxin, also called ectonucleotide pyrophosphatase/phosphodiesterase 2 (ENPP2), is a lysophospholipase D that releases LPA from lysophosphatidylcholine. LPA signals through G protein-coupled receptors to regulate cell proliferation, migration and survival. Autotaxin has therefore been studied in cancer cell motility, fibrosis and inflammation. In mouse models, autotaxin expression in the lung contributes to the development of pulmonary fibrosis. Compounds in this category include PF-8380, HA130, PAT-505 and Autotaxin-IN-1, for studies of the autotaxin-LPA axis.

Items 51-52 of 52

  • CRT0273750
    Cat. No.
    A61143
    CAS No.
    1979939-16-6

    CRT0273750

    Synonyms: IOA-289

    CRT0273750 is an inhibitor of autotaxin (ATX), which plays a crucial role in the modulation of lysophosphatidic acid (LPA) levels, exhibiting an IC50 of 0.014 μM. This compound is valuable in the study of ATX/LPA-dependent cancer models, contributing to research on tumor progression and metastasis. Its specificity for ATX provides a useful tool for elucidating the underlying mechanisms of LPA-mediated signaling pathways in various biological contexts.

    In stock View Details
    1 mg
    $30.00
    5 mg
    $35.00
    All 6 sizes
  • CBT-295
    Cat. No.
    A64894
    CAS No.
    1623794-90-0

    CBT-295

    CBT-295 is an orally active inhibitor of autotaxin (ATX), a key enzyme implicated in various inflammatory processes. This compound significantly decreases inflammatory cytokines such as TGF-β, TNF-α, and IL-6, while also lowering bile duct proliferation marker CK-19 and mitigating liver fibrosis. CBT-295's ability to reverse liver fibrosis correlates with reduced blood and brain ammonia levels, as well as diminished neuroinflammation caused by ammonia. It presents a valuable tool for research focused on liver cirrhosis and associated encephalopathy.

    In stock View Details
    5 mg
    $85.00
    10 mg
    $140.00
    All 5 sizes

Items 51-52 of 52

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