Autotaxin (ENPP2)

Cat. No.

A42195

CAS No.

1306684-90-1

4-Pentadecylbenzylphosphonic acid

4-Pentadecylbenzylphosphonic acid is an inhibitor of Autotaxin (ATX), a lysophosphatidate-producing enzyme involved in various pathophysiological processes. This compound demonstrates antitumor activity, making it valuable for cancer research. Its ability to modulate ATX activity provides insights into tumor progression and therapeutic strategies targeting the tumor microenvironment.

Cat. No.

A42197

CAS No.

3047891-88-0

MEY-003

MEY-003 is a specific inhibitor of Autotaxin (ATX), exhibiting half-maximal inhibitory concentration (EC50) values of 460 nM and 1.09 μM for human ATX isoforms β and γ, respectively, when analyzed with LPC18:1. As a non-competitive inhibitor with a Ki value of 432 nM, MEY-003 is a valuable tool for studying ATX-related disease mechanisms and therapeutic strategies. Its potent inhibition of ATX activity supports research into various biological processes, particularly those associated with inflammation and cancer.

Cat. No.

A61143

CAS No.

1979939-16-6

CRT0273750

Synonyms: IOA-289

CRT0273750 is an inhibitor of autotaxin (ATX), which plays a crucial role in the modulation of lysophosphatidic acid (LPA) levels, exhibiting an IC50 of 0.014 μM. This compound is valuable in the study of ATX/LPA-dependent cancer models, contributing to research on tumor progression and metastasis. Its specificity for ATX provides a useful tool for elucidating the underlying mechanisms of LPA-mediated signaling pathways in various biological contexts.

Cat. No.

A64894

CAS No.

1623794-90-0

CBT-295

CBT-295 is an orally active inhibitor of autotaxin (ATX), a key enzyme implicated in various inflammatory processes. This compound significantly decreases inflammatory cytokines such as TGF-β, TNF-α, and IL-6, while also lowering bile duct proliferation marker CK-19 and mitigating liver fibrosis. CBT-295's ability to reverse liver fibrosis correlates with reduced blood and brain ammonia levels, as well as diminished neuroinflammation caused by ammonia. It presents a valuable tool for research focused on liver cirrhosis and associated encephalopathy.