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All Dyes is the single product list for the Fluorescent Dyes, Probes & Stains section. Many dyes here have no application or dye-family subcategory, so the list is the broadest way to browse the range. It suits searches by product name when the required dye is already known. Examples range from the near-infrared cyanine indocyanine green and the ratiometric calcium indicator Fura-2 pentapotassium to the nucleic acid stains Hoechst 33258 trihydrochloride and SYBR Green II. Classical stains such as hematoxylin, reactive labeling dyes and enzyme substrates are listed alongside them. For selection by task or by core structure, the parent Fluorescent Dyes, Probes & Stains page groups dyes by application and dye family.
Synonyms: JF525; SE; NHS
Janelia Fluor 525, SE is a yellow fluorescent dye characterized by excitation at 525 nm and emission at 549 nm. This compound features an NHS ester, enabling efficient labeling of primary amines for various applications. It is particularly suitable for live cell imaging, facilitating studies in fluorescence microscopy and cellular tracking.
Synonyms: JF549 TFA
Janelia Fluor® 549 TFA (JF549 TFA) is a fluorescent dye that exhibits a maximum absorption wavelength of 549 nm and an emission maximum of 571 nm. This product is utilized in advanced imaging techniques, particularly in fluorescence microscopy, enabling high-resolution visualization of cellular structures and dynamics. Janelia Fluor® dyes are recognized for their exceptional brightness and photostability, making them suitable for long-term studies in biological research applications.
Fura Red is a Ca2+-sensitive fluorescent dye that exhibits decreased fluorescence in response to increasing calcium ion concentrations. This property makes it an invaluable tool for monitoring intracellular calcium dynamics and studying calcium signaling pathways in various cell types. Fura Red is ideal for applications in live-cell imaging and fluorescence microscopy, facilitating the examination of physiological processes affected by calcium levels.
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Thiofluor 623 is a fluorescent probe designed for the selective sensing and bioimaging of thiols. It operates on a turn-on mechanism, becoming highly fluorescent upon reaction with thiols, which cleave the probe to release a red-emissive donor-acceptor fluorophore (Ex=563 nm, Em=623 nm). Notably, Thiofluor 623 exhibits excellent selectivity against interference from nitrogen and oxygen nucleophiles, making it an ideal tool for biological applications that require sensitive detection of thiol compounds.
Cyanine3 amine hydrochloride is a fluorescent dye characterized by its primary amine group, allowing for efficient covalent coupling with reactive groups such as NHS esters, carboxy groups (post-carbodiimide activation), and epoxides. This compound exhibits strong green fluorescence with excitation and emission maxima at 555 nm and 570 nm, respectively. It is widely utilized in biological research applications, including protein labeling, cellular imaging, and monitoring of biological processes.
JFX650 is a red fluorescent deuterated dye that emits light at an excitation wavelength of 650 nm and an emission maximum of 667 nm. This dye is ideally suited for live cell imaging applications, providing excellent signal stability and brightness. Its properties enable researchers to visualize cellular processes and dynamics in real-time, making it a valuable tool in fluorescence microscopy studies.
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Synonyms: 2,6-Diiodo-Pyrromethene 546
2,6-Diiodo-BODIPY 493/503 is a fluorescent dye characterized by diiodo substitution at the 2,6 positions of the pyrrole ring. This modification imparts red fluorescence, making it suitable for various applications in bioimaging and cellular studies. Its distinct optical properties enable researchers to utilize this compound in tracking cellular processes and visualizing biomolecules in live-cell assays.
Synonyms: Acid Red 52; Kiton Red 620
Sulforhodamine B sodium salt is a fluorescent dye primarily utilized for laser-induced fluorescence (LIF) applications. It exhibits strong fluorescence properties, making it suitable for the quantification of cellular proteins in cultured cells. This dye is widely employed in various research fields, including cell biology and biochemistry, facilitating studies on protein expression and cellular behavior.
Rhodamine B hydrazide is a fluorescent probe that targets metal ions and reactive species. This compound is effective in detecting copper ions (Cu2+), mercury ions, peroxynitrite, hydroxyl radicals, and nitric oxide (NO). It exhibits an excitation/emission wavelength of 510/578 nm for conventional fluorescence detection and alternative wavelengths of 554 nm absorption and 574 nm emission for specific sulfite detection, making it a versatile tool for various biological and chemical research applications.
Synonyms: Sulfo-Cyanine5-azide
CY5-N3 (Sulfo-Cyanine5-azide) is a cell-permeable fluorescent dye, with excitation and emission wavelengths of 646 nm and 662 nm, respectively. This compound is designed for use in live cell imaging applications, enabling visualization of cellular processes in real time. CY5-N3 can be utilized effectively in Click chemistry reactions for conjugating with various biomolecules, facilitating enhanced imaging strategies in biological research.
Synonyms: 6-FAM azide
FAM azide, 6-isomer is a derivative of 6-carboxyfluorescein featuring an azide functional group, serving as a coupling partner in copper-catalyzed azide-alkyne cycloaddition reactions. This fluorescent dye is crucial for synthesizing fluorescently labeled disparlure enantiomers, which are used in pheromone-binding protein binding assays. Additionally, FAM azide, 6-isomer is commonly utilized for labeling oligonucleotides, exhibiting excitation and emission maxima at 493 and 517 nm, respectively.
Synonyms: BODIPY FL,SE
BODIPY-FL NHS ester is a cell membrane-permeable, amine-reactive fluorescent probe that exhibits strong fluorescence with a maximum excitation wavelength of 502 nm and an emission wavelength of 511 nm. This reagent demonstrates exceptional stability and is resistant to changes in polarity, pH, and solvent type, ensuring consistent fluorescence under diverse experimental conditions. BODIPY-FL NHS ester is ideal for applications such as live cell imaging, protein labeling, immunoassays, and the synthesis of protease substrates, making it a versatile tool for fluorescent-based research.
Synonyms: FD&C Green No. 3; Food green 3; C.I. 42053
Fast Green FCF is a sea green triarylmethane food dye known for its absorption maximum between 622 and 626 nm. This compound exhibits inhibitory effects on α-synuclein aggregation, the amyloid beta (Aβ) peptide, P2X4 receptors, and the TLR4/Myd88/NF-κB signaling pathway. Fast Green FCF is utilized as a quantitative stain for histones at alkaline pH following acid extraction of DNA, as well as a protein stain in electrophoresis applications. Additionally, it has shown potential benefits in addressing cognitive impairment, mood disorders, pain allergies, and reproductive function.
ICG Maleimide is a thiol-reactive near-infrared (NIR) fluorescent dye that serves as a vital fluorochrome in bioimaging applications. It exhibits excitation and emission wavelengths of 789 nm and 813 nm, respectively, enabling the generation of stable fluorescence signals. This compound is widely used in biological research for visualizing cellular structures and tracking biomolecules in live-cell imaging studies.
BODIPY FL-C16 is a fluorescent probe that incorporates a BODIPY FL dye linked to a sixteen-carbon fatty acid chain, targeting lipid metabolism. This reagent is utilized in research applications to study lipid dynamics, cellular membrane behavior, and metabolic pathways related to fatty acids. Its fluorescent properties facilitate the visualization and tracking of lipid localization and transport in biological systems.
AF647-NHS ester is a far-red fluorescent dye that primarily targets amino groups for covalent attachment to biomolecules such as proteins and antibodies. With an excitation wavelength of 635 nm for conventional fluorescence detection and 620 nm for instantaneous detection, it is ideal for a variety of applications in imaging and labeling. This reagent is particularly useful in studies requiring sensitive imaging and tracking of biomolecular interactions. Store protected from light to maintain optimal performance.
800CW NHS ester is a near-infrared fluorescent dye featuring an active ester moiety, enabling efficient conjugation with amine-containing small molecules, antibodies, and peptides to create fluorescent conjugates. This reagent is characterized by a high fluorescence quantum yield and minimal non-specific binding. 800CW NHS ester is suitable for various biomedical research applications, including microbial infection imaging, tumor visualization, and biochemical detection assays.
Synonyms: 5-Carboxyfluorescein diacetate
5-CFDA is a fluorescent dye that enables cellular imaging through its mechanism of free diffusion into cells. Once inside, it is hydrolyzed by intracellular non-specific lipases to yield carboxyl fluorescein (CF), which bears an additional negative charge, enhancing its cellular retention compared to standard fluorescein dyes. This compound is widely used in biological research for tracing cellular uptake and monitoring cellular activity in various applications.
Cy7.5 NHS ester is a fluorescent dye that primarily targets biological imaging applications. Its reactive NHS ester enables efficient conjugation to various biomolecules, such as mPEG-b-PDPA, to create fluorescent copolymers. Cy7.5 NHS ester is suitable for fluorescent imaging studies, with excitation and emission wavelengths at 780 nm and 820 nm, respectively, facilitating high-resolution visualization in research settings.
Synonyms: Cyanine2 Succinimidyl Ester (iodine)
Cy2-SE (iodine) is an amino fluorescent dye that falls under the category of Cyanine dyes. These compounds are characterized by their long wavelength absorption and emission properties, high extinction coefficients, and excellent water solubility. Cy2-SE is particularly useful for the labeling of proteins, antibodies, and small molecular compounds, facilitating the study of biomolecular interactions. The labeling process can be efficiently achieved through a straightforward mixing reaction, making it a valuable tool in various biological research applications, including fluorescence microscopy and flow cytometry.
Synonyms: Sulfo-Cy3 NHS ester; Sulfo Cyanine3 NHS ester
CY3-SE is a sulfonated cyanine dye that functions as a fluorescent labeling reagent. With an excitation wavelength of approximately 515 nm and an emission wavelength around 568 nm, CY3-SE effectively interacts with biomolecules such as nucleoside monophosphates and proteins. This interaction inhibits photoisomerization, enhancing both the fluorescence quantum yield and lifetime, making it suitable for various biological research applications, including imaging and labeling studies.
Sulfo-Cy7.5 NHS ester is a hydrophilic near-infrared (NIR) dye designed for the modification of amine groups through its NHS ester functionality. Featuring a trimethylene bridge with a linker arm, this compound enables efficient attachment to proteins, peptides, and other biomolecules. Sulfo-Cy7.5 NHS ester is an invaluable tool for research applications involving NIR imaging, facilitating advanced studies in biological and biomedical fields.
ReAsH-EDT2 is a red fluorescent dye specifically designed to target proteins. This membrane-permeable biarsenical compound exhibits covalent binding to tetracysteine sequences, enabling precise imaging of protein dynamics. ReAsH-EDT2 is suitable for studies involving protein localization, trafficking, and visualization in live cells, facilitating important insights in cellular biology and protein function.
CO Probe 1 is a highly effective fluorescent carbon monoxide (CO) probe designed for real-time imaging applications. It operates by utilizing the Tsuji-Trost reaction, where CO reduces Pd2+ to Pd0 in the presence of PdCl₂, resulting in the removal of the allyl protecting group and subsequent release of fluorescein. This process allows for a significant fluorescence enhancement of up to 150 times within 20 minutes, exhibiting high selectivity and rapid response with minimal cytotoxicity. CO Probe 1 is particularly valuable for investigating pathological mechanisms associated with CO signaling regulation in conditions such as inflammation, vascular disease, and cancer.
Cyanine5.5 NHS ester chloride is a reactive dye designed for the labeling of proteins, antibodies, and small molecular compounds. It functions through covalent bonding to primary amines, allowing for the development of sensitive and specific assays. This dye is particularly useful in fluorescence imaging and various biochemical assays, enabling enhanced visualization of biological samples in research applications.
