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Browse reagents with product-specific evidence for calcium detection, measurement or staining. The selection includes different reporting formats; consult each product for its intended use and experimental conditions.
Calcium-sensitive fluorescent indicators and calcium-detection or staining reagents are not interchangeable. This page does not imply that every product measures free intracellular calcium. Indicator precursors, calcium-channel pharmacology and probes made by subsequent conjugation are outside this selection without evidence for the exact reagent.
Calcium Green BAPTA-2 AM is a fluorescent calcium indicator that selectively binds to free calcium ions, allowing for the measurement of intracellular calcium levels. Its high sensitivity and rapid response make it ideal for studying calcium signaling in live cells. This reagent is widely used in pharmacological studies and cellular imaging applications to investigate various physiological processes related to calcium dynamics.
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INDO 1 is a cell-impermeant fluorescent calcium indicator that selectively binds to Ca2+, leading to a shift in emission wavelength from 485 nm to 410 nm upon binding. This property makes INDO 1 valuable for monitoring intracellular calcium levels in various biological research applications, including studies of signal transduction and cellular activity. Its robust fluorescent response allows for precise measurements, facilitating advancements in understanding calcium-related physiological processes.
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Fura PE-3 potassium is a calcium-sensitive fluorophore designed for the measurement of intracellular calcium concentrations. This reagent is particularly effective for loading into intrapulmonary arteries (IPA) and mesenteric resistance arteries (MA), facilitating the study of vasoconstriction mechanisms. Fura PE-3 potassium is widely utilized in calcium imaging applications, enhancing the understanding of vascular function and calcium-related signaling pathways in various biological contexts.
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FURA-PE3/AM is a fluorescent calcium indicator dye designed to detect intracellular calcium levels. Its leak-resistant properties enhance signal fidelity during cellular imaging, making it suitable for applications in studies of calcium signaling dynamics in live cells. This reagent is widely utilized in diverse research fields, including neurobiology and pharmacology, to investigate calcium-dependent cellular processes.
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BTC tetrapotassium is a cell-impermeant calcium indicator that targets calcium ions with a dissociation constant (Kd) of approximately 7-26 µM. This reagent exhibits several advantageous properties for cellular calcium imaging, including long excitation wavelengths at 400/485 nm and minimal interference from magnesium ions. Its reliability in providing accurate ratiometric measurements makes it a valuable tool for researchers investigating calcium dynamics in various biological systems.
Synonyms: ARS sodium
Alizarin Red S sodium is an anthraquinone-derived dye that specifically targets calcium deposits. This reagent forms coordination bonds with calcium ions, resulting in an orange-red fluorescence that can be detected under excitation at 500 nm and emission at 570 nm. Alizarin Red S sodium is widely used in research applications for screening calcium compounds in synovial fluid, detecting osteoblast differentiation, and visualizing bone structures in murine models.
Synonyms: Kernechtrot
Nuclear Fast Red is an anthraquinone dye that serves as a fluorescent probe targeting guanine. As a highly sensitive "off/on" probe, it is capable of detecting guanine with increased specificity. Additionally, Nuclear Fast Red is utilized as a histochemical and colorimetric reagent for calcium staining, often in combination with aluminum ions as a red nuclear counterstain. Its applications span various fields of biological research, including histology and nucleic acid detection.
Alizarin cyanin green F is a fluorescent dye that interacts with calcium ions, likely through its sulfonic acid and hydroxyl groups. This compound is widely used in biological research for visualizing calcium distribution in tissues and cells. Its fluorescent properties enable effective imaging and analysis in studies of cellular processes and mineralization.
Synonyms: Green 488 BAPTA 1AM
BAPTA Green 1AM is a cell-permeable fluorescent calcium indicator that utilizes Oregon Green 488 as a green fluorophore and BAPTA as the calcium chelator. This reagent provides a sensitive method for measuring intracellular calcium levels, enabling researchers to investigate various cellular processes influenced by calcium signaling. BAPTA Green 1AM is widely used in studies related to cellular physiology, signal transduction, and neuronal activity.
Dipyrrometheneboron difluoride is a green-fluorescent dye that serves as a fluorochrome, effectively labeling nonpolar lipids and facilitating the detection of calcium ions. Its unique photophysical properties make it valuable for various fluorescence-based applications in biological research, including imaging and characterization of membrane dynamics and calcium signaling. This reagent is essential for studies requiring precise localization of lipids and real-time monitoring of calcium concentrations in live cells.
Fura-FF AM is a cell-permeable acetoxymethyl ester of the fluorescent calcium indicator fura-FF. Upon intramolecular hydrolysis by intracellular esterases, it releases fura-FF within cells. As a difluorinated derivative of fura-2, Fura-FF exhibits a lower affinity for calcium, making it ideal for investigating calcium-rich compartments. This reagent is widely used in cellular imaging and calcium dynamics studies.
Rhod-5N is a cell-impermeant calcium-binding fluorescent dye that features a BAPTA chelating group linked to a rhodamine fluorophore. This dye is particularly effective in detecting cation content in MOPS buffer, demonstrating a higher selectivity for Cd2+ over other common cations such as Na+, K+, Mg2+, Ca2+, and Zn2+, with the exception of Pb2+. Its sensitivity allows for detection at a limit of 3.1 μg/L, making it a valuable tool for research applications in calcium signaling and metal ion detection.
Acid alizarin red B is a fluorescent dye primarily utilized for calcium detection in biological samples. Its vibrant scarlet hue enables clear visualization and quantification of calcium ions, making it a valuable tool in various research applications, including cell biology and histology. The compound’s ability to bind with calcium facilitates detailed studies of calcium homeostasis and related cellular processes.
FFP-18-AM is a cell-permeable fluorochrome designed for the detection of near-membrane calcium levels. This fluorescent indicator enables researchers to visualize and quantify calcium dynamics within cellular environments. Its application is crucial in studying calcium signaling pathways and related physiological processes in various cell types.
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Fura-5F pentapotassium is a cell-impermeant fluorescent calcium indicator that primarily targets calcium ions. It exhibits enhanced fluorescence upon binding to calcium, making it an essential tool for studying calcium dynamics in various biological systems. This reagent is commonly used in fluorescence microscopy and spectrofluorometry for investigating cellular calcium signaling and related physiological processes.
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Fura-4F pentapotassium is a cell-impermeant fluorochrome specifically designed as a fluorescent indicator for measuring intracellular calcium ion concentrations. Its unique properties enable precise detection of calcium influx in living cells, making it valuable for studies in cellular signaling and physiological processes. This reagent is ideal for applications in pharmacology, neuroscience, and cell biology.
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Fluo-3 pentapotassium is a cell-impermeable fluorochrome primarily used as a calcium ion (Ca2+) indicator. This compound is non-fluorescent in its native state, but upon binding to calcium ions, it exhibits increased fluorescence with an excitation/emission maximum at 488/525 nm. Fluo-3 pentapotassium is widely applicable in cellular studies to measure intracellular calcium levels and assess cellular signaling pathways.
Fluo-3FF AM is a calcium indicator with a low affinity for calcium ions (Kd = 42 μM), designed to allow for the monitoring of intracellular calcium levels. With an absorption/emission maximum of 462 nm/526 nm, it remains non-fluorescent until it enters cells and binds to calcium, resulting in a marked fluorescence enhancement. Fluo-3FF AM is insensitive to magnesium ions and demonstrates relative photostability, making it suitable for various biological research applications involving calcium signaling pathways.
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FG 488 BAPTA-2 AM is a calcium-specific reporter dye that serves as a vital tool for quantifying intracellular calcium levels. Through its high affinity for calcium ions, this fluorescent probe enables real-time monitoring of calcium dynamics in live cells. It is particularly valuable in research applications involving cell signaling, neuronal activity, and muscle contraction studies.
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Alizarin complexone dihydrate is a calcium-binding fluorescent dye primarily used for visualizing mineralized areas in bone tissues. Its ability to bind calcium crystals enables effective staining, making it a valuable tool in bone research. Additionally, Alizarin complexone exhibits inhibitory effects on the reverse transcriptase activity of RAV-2, HIV-1, and RSV, with IC50 values of 3.8 μg/mL, 45 μg/mL, and 100 μg/mL, respectively, indicating its potential as an antiviral agent. Furthermore, it has been shown to delay RSV-induced tumor induction in avian models.
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Synonyms: ARS
Alizarin Red S is an anthraquinone derivative dye primarily utilized for visualizing calcium deposits. It forms a coordination bond with calcium ions, resulting in an orange-red fluorescence, making it useful for detecting osteoblast differentiation and screening calcium compounds in synovial fluid. This reagent is also commonly employed for bone staining in murine models. The excitation and emission wavelengths are 500 nm and 570 nm, respectively.
Rhod-2 triammonium is a cell impermeant red fluorescent calcium ion probe that targets calcium binding. This reagent exhibits a notable increase in fluorescence intensity upon calcium binding, with excitation maxima shifting from 549 nm in the calcium-free state to 552 nm in the calcium-bound state, and emission maxima at 581 nm. Rhod-2 triammonium is ideal for studying intracellular calcium dynamics and monitoring calcium fluctuations in live cells without the spectral shifts associated with UV-excitable indicators.
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5,5'-Difluoro BAPTA is a selective calcium probe that targets intracellular calcium ions (Ca2+), enabling precise studies of cytosolic free Ca2+ levels. This difluoro derivative is recognized for its utility in NMR spectroscopy, particularly 19F NMR, to monitor changes in calcium concentration within various biological systems. In addition to its role as a calcium indicator, 5,5'-Difluoro BAPTA has been shown to inhibit the growth of pollen tubes, highlighting its potential applications in plant biology and developmental studies.
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Fluo-4 potassium is a fluorescent dye designed for the selective detection of intracellular calcium ions (Ca2+). With an excitation wavelength of 494 nm and an emission wavelength of 516 nm, it serves as an effective indicator for monitoring calcium dynamics in live cells. Fluo-4 potassium is primarily utilized in research applications involving signal transduction, excitable cells, and calcium signaling studies, often introduced into cells through techniques such as patch clamping and microinjection.
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Calcein calcium potassium is a fluorescent dye that serves as a self-quenching probe, primarily utilized to assess lipid vesicle leakage and as a complexometric indicator for calcium ion titrations with EDTA. Due to its inability to cross intact cell membranes, it is valuable for studying cellular processes without influencing live cell conditions. Additionally, Calcein may be employed as a model drug to evaluate the efficiency and bioavailability of drug delivery systems in research applications.
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