Fluorescein Dyes

Cat. No.

A63558

CAS No.

1440755-31-6

Atrovastatin-PEG3-FITC

Atrovastatin-PEG3-FITC is a KRAS-PDEδ interaction inhibitor that serves as a valuable tool in the study of KRAS signaling pathways. This compound can function as a ligand in fluorescence anisotropy assays, enabling researchers to investigate protein-protein interactions and their implications in cancer biology. Its application aids in understanding the role of KRAS in various malignancies and exploring potential therapeutic interventions.

Cat. No.

A73431

CAS No.

168912-70-7

Cholylglycylamidofluorescein

Synonyms: CGamF

Cholylglycylamidofluorescein (CGamF) is a fluorescent probe designed to study hepatic bile acid transport mechanisms. This compound is composed of cholic acid linked through a glycylamino bond to fluorescein, offering a fluorescence excitation/emission maxima at 492/515 nm in aqueous solutions. CGamF is utilized in research applications involving bile acid metabolism and transport processes within liver cells, enabling in-depth studies of hepatic function and pathology.

Cat. No.

A75532

CAS No.

61419-02-1

Naphthofluorescein

Synonyms: Naphthafluorescein

Naphthofluorescein is a potent inhibitor of HIF-1 through the inhibition of HIF prolyl-hydroxylase activity. It effectively suppresses Mint3-dependent HIF-1 signaling and glycolytic activity in cancer cells and macrophages while exhibiting low cytotoxicity in vitro and negligible adverse effects in vivo. Additionally, Naphthofluorescein serves as a fluorescent pH-sensitive probe, making it suitable for functional Cerenkov imaging applications.

Cat. No.

A76532

CAS No.

2374144-23-5

FITC-GW3965

FITC-GW3965 is a fluorescence-labeled agonist of liver X receptor beta (LXRβ), designed to facilitate the study of LXRβ functions in biological systems. The compound is synthesized by replacing the trifluoromethyl group of GW3965 with an amide linkage to incorporate the FITC dye. FITC-GW3965 is valuable for research applications involving the exploration of lipid metabolism, cholesterol homeostasis, and gene regulation mediated by LXRβ.

Cat. No.

A86505

CAS No.

106070-31-9

2,7-Dichlorodihydrofluorescein

Synonyms: DCFH2

2,7-Dichlorodihydrofluorescein (DCFH2) is a non-fluorescent probe specifically designed to detect reactive oxygen species (ROS). Upon hydrolysis by intracellular esterases, DCFH2 reacts with various ROS, including hydroxyl radicals, hydrogen peroxide, and peroxynitrite, to produce the highly fluorescent compound 2,7-dichlorofluorescein (DCF). The fluorescence intensity of DCF directly correlates with ROS levels, making it an essential reagent for quantitatively assessing oxidative stress. This compound is suitable for both in vitro and in vivo applications, including oxidative stress analysis in cell models and targeted delivery studies, such as those utilizing liver-targeted liposomes.

Cat. No.

A87604

CAS No.

3012-71-3

6-Isothiocyanato-Fluorescein

Synonyms: FITC Isomer Ⅱ

6-Isothiocyanato-Fluorescein (FITC Isomer II) is a fluorescent dye used primarily as a biochemical assay reagent. It targets amine groups, enabling covalent labeling of proteins and other biomolecules. This property makes it valuable for various applications in cell biology, immunology, and fluorescence microscopy, facilitating the study of cellular processes and protein interactions.

Cat. No.

A92860

CAS No.

1032732-74-3

Biotin-4-Fluorescein

Biotin-4-Fluorescein is a fluorescent probe designed for the detection and quantification of (strept)avidin through biotin-binding interactions. Its strong fluorescent properties enable sensitive visualization and quantification in various biological samples. This reagent is particularly useful in applications such as immunohistochemistry, cell staining, and affinity chromatography, facilitating studies in biochemistry and molecular biology.

Cat. No.

A92983

CAS No.

2933358-06-4

DSPE-Fluorescein

DSPE-Fluorescein is a phospholipid that exhibits excellent biocompatibility and amphiphilic properties, making it an ideal candidate for drug formulation and delivery systems. Its unique characteristics enhance the solubility and bioavailability of therapeutic agents, contributing to improved therapeutic outcomes. DSPE-Fluorescein is widely utilized in drug delivery research to facilitate the targeting and release of pharmaceutical compounds.

Cat. No.

B11011

CAS No.

2768977-07-5

FAM DBCO, 6-isomer

FAM DBCO, 6-isomer is a fluorescent dye that incorporates a terminal dibenzocyclooctyne (DBCO) group, allowing for copper-free Click Chemistry applications. This compound exhibits high reactivity due to its strained structure, facilitating the efficient formation of covalent bonds in bioconjugation reactions. FAM DBCO can be utilized in a variety of biological applications, including cell labeling, tracking, and imaging studies.

Cat. No.

B11027

CAS No.

510758-23-3

FAM azide, 5-isomer

FAM azide, 5-isomer is a fluorescent dye commonly used in Click Chemistry for bioconjugation applications. This compound facilitates the labeling of biomolecules with minimal cytotoxicity, enhancing the visualization of cellular structures and processes. Its high fluorescence intensity makes it suitable for various applications, including live-cell imaging, biomolecule tracking, and the development of fluorescent probes in research and diagnostic assays.

Cat. No.

B11054

CAS No.

728912-45-6

Pentafluorobenzenesulfonyl fluorescein

Pentafluorobenzenesulfonyl fluorescein is a selective fluorescent probe designed for the detection of hydrogen peroxide (H2O2) within cellular environments. This compound exhibits minimal fluorescence in its native state, becoming markedly fluorescent upon cleavage of the sulfonyl linkage by H2O2. Its specific reactivity allows for effective monitoring of oxidative stress and related biological processes, making it a valuable tool for research in cell biology and redox signaling pathways.

Cat. No.

B11142

CAS No.

1926163-32-7

FITC-YVADAPK(Dnp)

FITC-YVADAPK(Dnp) is a fluorogenic substrate primarily used to study caspase-1 activity. Upon cleavage by caspase-1, the fluorescence intensity increases, allowing for quantitative analysis of enzyme activity in various biological samples. This reagent is suitable for applications in apoptosis research and the investigation of inflammatory responses.

Cat. No.

B11261

CAS No.

53360-53-5

5-Aminofluorescein hydrochloride

Synonyms: 5-AF hydrochloride

5-Aminofluorescein hydrochloride is a highly effective fluorescent dye primarily utilized for protein labeling. This reagent exhibits strong fluorescence activity, making it ideal for cell imaging and the development of molecular probes in biomedical research. Its capabilities enable the visualization of protein localization and dynamic changes, facilitating a deeper understanding of biological processes. Additionally, 5-Aminofluorescein hydrochloride is valuable for detecting interactions between biomolecules, thereby aiding in the analysis of complex biological phenomena.

Cat. No.

B11288

CAS No.

946123-11-1

Coumarin 343 X carboxylic acid

Coumarin 343 X carboxylic acid is a blue-emitting fluorophore utilized primarily as a laser dye. This compound exhibits its potential as a Förster resonance energy transfer (FRET) donor for fluorescein (FAM), making it valuable in fluorescence-based assays and applications that require sensitive detection. Its unique spectral properties enable its use in various biological and chemical research contexts, providing a versatile tool for researchers in the field.

Cat. No.

B11301

CAS No.

890090-41-2

FAM NHS ester, 6-isomer

FAM NHS ester, 6-isomer is a hydrophilic fluorescent dye that enables effective labeling of biomolecules. Its N-hydroxysuccinimide (NHS) ester group selectively reacts with primary amines, including those found in lysine residues and aminosilane-coated surfaces, under neutral to slightly basic conditions to form stable covalent bonds. This property makes it suitable for diverse applications in fluorescence microscopy, flow cytometry, and target protein labeling in biochemical research.

Cat. No.

B11338

CAS No.

630-88-6

3,6-Dichlorofluorescein

Synonyms: Fluorescein chloride

3,6-Dichlorofluorescein is a derivative of fluorescein, primarily used for its fluorescence properties in analytical chemistry. It serves as a reagent in spot tests, particularly for the detection of compounds containing amino and heterocyclic nitrogen. This compound’s sensitivity and ability to emit a strong fluorescent signal make it valuable for various biochemical assays and environmental monitoring applications.

Cat. No.

B11339

CAS No.

1619222-85-3

FAM tetrazine, 5-isomer

FAM tetrazine, 5-isomer is a fluorescent dye characterized by its terminal tetrazine group, facilitating rapid click chemistry reactions with trans-cyclooctene (TCO). This compound serves as a versatile labeling agent in various biological applications, including protein tagging, cellular imaging, and detection of biomolecular interactions. Its high fluorescence and effective reactivity make it a valuable tool for researchers in fields such as biochemistry and molecular biology.

Cat. No.

B11366

CAS No.

2702251-82-7

Difluorocarboxyfluorescein NHS Ester, 6-isomer

Difluorocarboxyfluorescein NHS Ester, 6-isomer is an amine-reactive fluorescent dye known for its enhanced photostability and lower pKa (approximately 4.7), which renders its fluorescence largely pH insensitive within physiological ranges. This dye is particularly suitable for the labeling of proteins, peptides, and nucleotides, offering significant improvements in resolution during HPLC purification when utilizing a single isomer. Researchers benefit from the dye's favorable characteristics in various applications, enabling precise tracking and analysis of biomolecules in complex biochemical studies.

Cat. No.

B11387

CAS No.

2086689-06-5

N-(Azido-PEG2)-N-fluorescein-PEG4-acid

N-(Azido-PEG2)-N-fluorescein-PEG4-acid is a fluorescein labeling reagent that features an azide group and a carboxylic acid moiety. It is designed for use in click chemistry, specifically facilitating copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkyne-containing molecules. This reagent is ideal for applications in bioconjugation and cellular imaging, enabling the fluorescent tagging of biomolecules for detailed analysis in chemical research.

Cat. No.

B21820

CAS No.

1379771-95-5

BODIPY FL azide

BODIPY FL azide is a BDP fluorescent dye characterized by an azide group that enables Click Chemistry. This green fluorophore, belonging to the borodipyrromethane class, exhibits a high quantum yield in aqueous solutions and demonstrates excellent stability against photobleaching. It is particularly suitable for applications requiring FAM fluorescence measurements, making it an ideal tool for various biochemical assays and cellular imaging studies.