Dopamine Receptors

Cat. No.

A59921

CAS No.

1216626-17-3

Amisulpride-d5

Synonyms: (Rac)-Aramisulpride-d5; (Rac)-Esamisulpride-d5; DAN 2163-d5

Amisulpride-d5 is a deuterium-labeled derivative of Amisulpride, a selective antagonist of the dopamine D2 and D3 receptors. It exhibits high affinity with Kis of 2.8 nM and 3.2 nM for human D2 and D3 receptors, respectively. This stable isotope is utilized in pharmacokinetic studies, metabolic research, and tracer studies to investigate the pharmacological properties and dynamics of dopamine receptor interactions.

Cat. No.

A59922

CAS No.

300561-58-4

SKF 77434 hydrobromide

SKF 77434 hydrobromide is a selective partial agonist of the dopamine D1 receptor. This compound exhibits key biological activity in modulating dopaminergic pathways, making it valuable for research into addiction mechanisms, particularly cocaine addiction. Its specificity for the D1 receptor supports investigations into the role of dopamine signaling in various neuropsychiatric conditions.

Cat. No.

A59924

CAS No.

13575-86-5

ADTN hydrobromide

ADTN hydrobromide is a long-acting dopamine agonist that targets dopamine receptors to modulate dopaminergic signaling. It has been shown to significantly decrease the behavioral visual threshold in zebrafish models with dopamine depletion, indicating its potential utility in studying dopamine-related pathways and neuropharmacology. This compound is valuable for research applications exploring dopamine receptor functions and related disorders.

Cat. No.

A59925

CAS No.

178928-68-2

NGD94-1

NGD94-1 is a potent and selective antagonist of the dopamine D4 receptor, exhibiting high affinity for the human D4.2 receptor (Ki = 3.6 nM). This compound plays a significant role in modulating cognitive functions within the frontostriatal system and regulates dopaminergic transmission, particularly in Phencyclidine (PCP)-induced models. NGD94-1 is suitable for applications in neurological disease research, providing valuable insights into dopaminergic mechanisms and their impact on cognition.

Cat. No.

A59926

CAS No.

1609580-97-3

(Rac)-PF-06256142

(Rac)-PF-06256142 is an agonist of the D1 receptor, exhibiting an EC50 of 107 nM. This compound plays a significant role in the study of dopaminergic signaling pathways and is relevant for research applications focused on psychiatric disorders such as schizophrenia and neurodegenerative conditions like Parkinson's disease. Its biological activity provides a useful tool for exploring the therapeutic potential of D1 receptor modulation in these diseases.

Cat. No.

A59928

CAS No.

1643462-93-4

(Rac)-Razpipadon

Synonyms: PW0464

(Rac)-Razpipadon is a selective D1 dopamine receptor agonist, demonstrating potent G protein-biased signaling with an EC50 of 5.8 nM in Gs-cAMP assays. This non-catechol compound is valuable for exploring dopamine D1 receptor pathways and studying related neurobiological processes. Its high efficacy makes it suitable for research applications focused on neuropharmacology and the modulation of dopaminergic signaling.

Cat. No.

A59929

CAS No.

316-81-4

Thioproperazine

Synonyms: RP 7843; SKF 5883; Thioperazine

Thioproperazine is an orally active antipsychotic agent primarily targeting dopaminergic pathways. It exhibits calming and antiemetic properties, making it effective for research into schizophrenia and bipolar disorder. Thioproperazine promotes the release of dopamine in the rat striatum, facilitating studies on its pharmacological effects and potential therapeutic applications in psychiatric disorders.

Cat. No.

A59931

CAS No.

114200-31-6

PAOPA

PAOPA is an allosteric modulator of the dopamine D2 receptor, derived from the analog of L-proline-L-leucine-glycine amide (PLG) peptide. This compound demonstrates significant potential in mitigating behavioral abnormalities in rodent models of schizophrenia. PAOPA enhances the receptor's affinity and promotes its binding to agonists, making it a valuable tool for research focused on neuropsychiatric disorders.

Cat. No.

A59932

CAS No.

1055411-77-2

Dopamine D2 receptor antagonist-1

Dopamine D2 receptor antagonist-1 is a negative allosteric modulator of the dopamine D2 receptor (D2R) that exhibits sub-micromolar affinity. This compound is utilized in research studying dopaminergic signaling pathways and provides insights into neurological disorders associated with D2R dysfunction. Its role in modulating receptor activity makes it a valuable tool for exploring pharmacological interventions in the central nervous system.

Cat. No.

A59933

CAS No.

80373-22-4

Quinpirole

Synonyms: LY 171555; (-)-LY 141865

Quinpirole is a selective agonist of the dopamine D2 and D3 receptors, primarily targeting central nervous system functions. It is known to reduce hypothalamic norepinephrine concentrations, influencing dopaminergic signaling pathways. Quinpirole's unique mechanism results in decreased dopamine metabolites and potential increased levels of 3-methoxy-4-hydroxyphenylglycol (MHPG) sulfate, making it valuable for research on neuropharmacology and the modulation of mood and behavior.

Cat. No.

A59934

CAS No.

220941-93-5

CP 226269

CP 226269 is a potent agonist of the dopamine D4 receptor, demonstrating significant calcium flux induction with an EC50 of 32 nM. This compound also stimulates phospholipid methylation (PLM) in SK-N-MC neuroblastoma cells, exhibiting an EC50 of 2.9 nM. CP 226269 is utilized in research related to schizophrenia and other neuropsychiatric disorders, providing valuable insights into dopamine receptor functions.

Cat. No.

A59935

CAS No.

1329509-60-5

OPC 4392 hydrochloride

OPC 4392 hydrochloride is a modulator of dopamine receptors, acting as an agonist at presynaptic receptors while antagonizing postsynaptic D2 receptors. This compound has demonstrated the ability to reverse dopamine accumulation induced by Reserpine and inhibit stereotypic and climbing behaviors triggered by Apomorphine in mouse models. It serves as a valuable tool for investigating dopamine-related pathways and behaviors in neurological research.

Cat. No.

A59937

CAS No.

883958-36-9

MLS1082

MLS1082 is a pyrimidone-derived positive allosteric modulator targeting the D1-like dopamine receptors. It exhibits an EC50 of 123 nM for enhancing dopamine-stimulated G protein signaling. This compound is valuable for research applications focused on dopamine receptor pharmacology and the modulation of neurotransmitter systems.

Cat. No.

A59938

CAS No.

131796-63-9

Odapipam

Synonyms: NNC 756

Odapipam (NNC 756) is a selective dopamine D1 receptor antagonist, exhibiting high affinity with a Kd of 0.18 nM. This compound serves as a valuable tool in neuroscience research, particularly for studying dopaminergic signaling pathways and related neuropsychiatric disorders. In addition, Odapipam functions as an effective radiotracer for positron emission tomography (PET) imaging, enhancing the investigation of receptor dynamics in vivo.

Cat. No.

A59940

CAS No.

88768-67-6

Preclamol hydrochloride

Synonyms: (-)-3-PPP hydrochloride

Preclamol hydrochloride is a selective dopamine autoreceptor agonist, primarily targeting the D2 dopamine receptor. This compound exhibits significant biological activity in modulating dopamine signaling, making it a valuable tool for investigating the pathophysiology of schizophrenia. Its applications extend to neuropharmacology studies, aiding in the development of therapeutic strategies for dopaminergic dysregulation.

Cat. No.

A59941

CAS No.

145307-34-2

A-77636 hydrochloride

A-77636 hydrochloride is a selective and potent dopamine D1 receptor agonist with an antiparkinsonian profile, characterized by a pKi of 7.40 and a Ki of 39.8 nM. This compound is known for its long-lasting effects and is functionally inactive at the dopamine D2 receptor, making it a valuable tool for studying dopamine signaling and potential therapeutic interventions in Parkinson's disease. Its specificity and activity make A-77636 hydrochloride suitable for research focusing on dopaminergic systems and related neuropharmacological applications.

Cat. No.

A59943

CAS No.

587870-77-7

ABT-724 trihydrochloride

ABT-724 trihydrochloride is a highly selective agonist for the dopamine D4 receptor, exhibiting an EC50 of 12.4 nM for the human receptor. This compound also demonstrates potency as a partial agonist for rat and ferret D4 receptors, with EC50 values of 14.3 nM and 23.2 nM, respectively, while showing no activity on dopamine D1, D2, D3, or D5 receptors. ABT-724 trihydrochloride holds potential for exploring therapeutic applications in erectile dysfunction, with a favorable side effect profile for further research studies.

Cat. No.

A59944

CAS No.

1221408-42-9

YQA14

YQA14 is a high-affinity antagonist of the dopamine D3 receptor. It exhibits significant anti-opioid addiction activity, demonstrating the ability to inhibit morphine- and cocaine-induced conditioned place preference (CPP) in preclinical models. This compound is valuable for research into the mechanisms of addiction and the development of therapeutic strategies for substance use disorders.

Cat. No.

A59945

CAS No.

67287-95-0

SKF 83959 hydrobromide

SKF 83959 hydrobromide is a potent partial agonist of the dopamine D1-like receptors, demonstrating Ki values of 1.18 nM for D1, 7.56 nM for D5, and significantly higher values for D2 and D3 receptors. This compound also acts as a powerful allosteric modulator of the sigma (σ)-1 receptor and belongs to the benzazepine class. SKF 83959 hydrobromide is utilized in research focused on cognitive dysfunction, with applications in studying Alzheimer's disease and depression.

Cat. No.

A59946

CAS No.

76135-30-3

7-Hydroxy-DPAT hydrobromide

7-Hydroxy-DPAT hydrobromide is a selective agonist for the D3 dopamine receptor, primarily impacting dopamine signaling pathways. This compound demonstrates significant biological activity in modulating locomotor behavior and influencing dopamine metabolism within the central nervous system. It serves as a valuable tool for research applications related to neuropharmacology and the study of dopamine-related disorders.

Cat. No.

A59947

CAS No.

101626-70-4

Talipexole

Synonyms: B-HT 920

Talipexole is a selective dopamine receptor agonist primarily targeting D2-like receptors. It is proposed for use as an antiparkinsonian agent, demonstrating potential in improving motor function in Parkinson's disease models. Research applications include studying dopaminergic signaling pathways and exploring therapeutic options for neurodegenerative disorders.

Cat. No.

A59948

CAS No.

2562346-14-7

Mesdopetam hemitartrate

Synonyms: IRL790 hemitartrate

Mesdopetam hemitartrate is a selective antagonist of the dopamine D3 receptor, exhibiting a Ki value of 90 nM and an IC50 of 9.8 μM for human recombinant D3 receptors. This compound demonstrates psychomotor stabilizing effects, making it a valuable tool in the investigation of motor and psychiatric complications associated with Parkinson's disease. Its unique properties contribute to research aimed at understanding the underlying mechanisms of dopamine-related disorders.

Cat. No.

A59949

CAS No.

1403894-72-3

Mesdopetam

Synonyms: IRL790

Mesdopetam is a selective antagonist of the dopamine D3 receptor, displaying a Ki value of 90 nM and an IC50 of 9.8 μM for the human recombinant D3 receptor. This compound exhibits psychomotor stabilizing properties and is utilized in research focused on motor and psychiatric complications associated with Parkinson's disease. Its role in modulating dopamine signaling makes it valuable for studying therapeutic strategies in this context.

Cat. No.

A59950

CAS No.

1782532-06-2

PD 168568 dihydrochloride

PD 168568 dihydrochloride is a potent and orally active antagonist of the dopamine receptor D4 (DRD4). This compound exhibits selectivity for the D4 receptor, with Ki values of 8.8 nM for DRD4 compared to 1842 nM for DRD2 and 2682 nM for DRD3. PD 168568 dihydrochloride is applicable in glioblastoma (GBM) research, making it a valuable tool for investigating the role of DRD4 in cancer biology and potential therapeutic strategies.

Cat. No.

A59951

CAS No.

89874-80-6

(R)-Preclamol hydrochloride

Synonyms: (+)-3-PPP hydrochloride

(R)-Preclamol hydrochloride is a dopamine (DA) agonist characterized by its ability to stimulate both dopamine autoreceptors and postsynaptic receptors. This compound is instrumental in research focused on the modulation of dopaminergic pathways, making it a valuable tool for studying dopamine-related physiological and neurobiological processes. Its unique enantiomeric properties enhance its potential applications in pharmacological studies and behavioral research.