Dopamine Receptors

Cat. No.

A59854

CAS No.

85798-08-9

Quinpirole hydrochloride

Synonyms: LY 171555 hydrochloride; (-)-LY 141865 hydrochloride

Quinpirole hydrochloride functions as a high-affinity agonist for the dopamine D2 and D3 receptors. This compound is primarily utilized in research applications focused on neuropharmacology and the exploration of dopaminergic signaling pathways. Quinpirole hydrochloride serves as an important tool for studying the effects of dopamine receptor activation in various in vitro and in vivo models.

Cat. No.

A59855

CAS No.

71636-61-8

SKF 81297

SKF 81297 is a potent and selective agonist of the dopamine D1 receptor. This compound is primarily utilized in research exploring dopaminergic signaling pathways and has shown efficacy in modulating neurotransmitter release. Its applications extend to studies on neuropsychiatric disorders and the characterization of D1 receptor functions in various biological systems.

Cat. No.

A59856

CAS No.

67287-39-2

SKF 81297 hydrobromide

SKF 81297 hydrobromide is a potent and selective agonist of the dopamine D1 receptor. This compound is used extensively in research to investigate the role of D1 receptor activation in various physiological and pathological processes. Its biological activity makes it valuable for studying neuropharmacology, synaptic plasticity, and the modulation of dopaminergic signaling pathways.

Cat. No.

A59857

CAS No.

104632-26-0

Pramipexole

Pramipexole is a selective dopamine D2-type receptor agonist that effectively penetrates the blood-brain barrier. It exhibits high affinity with Kis of 2.2 nM for the D2-type receptor, 3.9 nM for D2, 0.5 nM for D3, and 1.3 nM for D4 receptors. This compound is utilized in research related to Parkinson's disease and restless legs syndrome, supporting studies aimed at understanding and treating these neurological disorders.

Cat. No.

A59858

CAS No.

97612-24-3

Eticlopride hydrochloride

Eticlopride hydrochloride is a selective antagonist of the dopamine D2 receptor, demonstrating high binding affinity for D2, α1-adrenergic, α2-adrenergic, and various serotonin receptors. This compound has KIs of 0.09 nM for D2, 112 nM for α1, 699 nM for α2, 6220 nM for 5HT1, and 830 nM for 5HT2. Eticlopride hydrochloride is primarily utilized in research related to antipsychotic mechanisms and dopamine signaling pathways.

Cat. No.

A59859

CAS No.

137417-08-4

Dihydrexidine hydrochloride (DAR-0100 hydrochloride)

Synonyms: DAR-0100 hydrochloride

Dihydrexidine hydrochloride is a potent and selective agonist of the D1-like dopamine receptors (D1/D5), exhibiting an IC50 of 10 nM for the D1 receptor. This compound demonstrates significant antiparkinsonian activity, making it valuable in neurological research. Additionally, Dihydrexidine hydrochloride has been shown to stimulate YAP phosphorylation, indicating its potential role in cellular signaling studies.

Cat. No.

A59860

CAS No.

18016-80-3

Lisuride

Lisuride is an orally active agonist of the dopamine D2 receptor, primarily utilized in neurological research. This ergot derivative is valuable for investigating conditions such as Parkinson's disease, migraine disorders, and hyperprolactinemia. Its ability to modulate dopamine activity makes Lisuride a significant compound for studying dopaminergic pathways and associated therapeutic strategies.

Cat. No.

A59861

CAS No.

19875-60-6

Lisuride maleate

Lisuride maleate is a potent dopamine agonist that acts directly on dopaminergic receptors. As an ergot derivative, it is primarily utilized in research to investigate its effects on dopamine-related pathways and conditions. Lisuride maleate shows potential in alleviating premenstrual mastalgia while exhibiting minimal side effects, making it a valuable tool for studies focused on neuropharmacology and hormonal regulation.

Cat. No.

A59862

CAS No.

52468-60-7

Flunarizine

Flunarizine is a potent dual blocker of Na+ and Ca2+ channels, specifically targeting T-type channels. It acts as a D2 dopamine receptor antagonist, exhibiting notable anticonvulsive and antimigraine properties. Additionally, flunarizine demonstrates peripheral vasodilatory effects, making it useful in research related to neurological disorders and vascular function.

Cat. No.

A59863

CAS No.

130465-39-3

A68930 hydrochloride

A68930 hydrochloride is a selective agonist for the dopamine D1 receptor, which plays a crucial role in various neurological and physiological processes. Its activation of the D1 receptor is significant in the study of conditions such as bronchiectasis. This reagent is valuable for investigating the role of dopamine signaling in respiratory disorders and may contribute to the understanding of therapeutic strategies involving dopamine modulation.

Cat. No.

A59864

CAS No.

3819-00-9

Piperacetazine

Piperacetazine is a phenothiazine antipsychotic that primarily functions as a dopamine receptor antagonist. It has demonstrated inhibitory effects on the transcriptional activity of the PAX3::FOXO1 fusion protein, along with antitumor activity, exhibiting an IC50 of 7.627 μM against PANC-1 cells. This compound is applicable in research related to schizophrenia, pancreatic cancer, and other tumor types, making it a valuable tool for studying both neuropsychiatric disorders and cancer biology.

Cat. No.

A59865

CAS No.

1643489-24-0

Tavapadon

Synonyms: PF-06649751; CVL-751

Tavapadon is a selective partial agonist of the dopamine D1 and D5 receptors. This orally active compound demonstrates significant efficacy in promoting motor function and alleviating disability, making it a promising candidate for research into Parkinson’s disease therapies. Tavapadon’s unique pharmacological profile supports its potential application in neurologic studies and drug development aimed at addressing dopamine-related disorders.

Cat. No.

A59866

CAS No.

522-97-4

Tetrahydroberberine

Synonyms: Canadine

Tetrahydroberberine is a potent dopamine D2 receptor antagonist, which modulates dopaminergic signaling pathways. Its biological activity includes potential gastrointestinal benefits, such as enhancing gastric function and alleviating gastric pressure. This compound is of interest in research applications focused on neuropharmacology and gastrointestinal physiology.

Cat. No.

A59868

CAS No.

158985-00-3

L-745870

L-745870 is a highly selective antagonist of the dopamine D4 receptor, demonstrating a Ki of 0.43 nM. It exhibits limited affinity for D2 (Ki of 960 nM) and D3 (Ki of 2300 nM) receptors, along with moderate affinity for 5-HT2 receptors, sigma sites, and α-adrenoceptors. This compound is suitable for studies investigating the role of the dopamine D4 receptor in neurological disorders and provides insights into neuropharmacology-related research applications.

Cat. No.

A59869

CAS No.

1638667-79-4

LY3154207

LY3154207 is a highly selective positive allosteric modulator (PAM) of the human dopamine D1 receptor, demonstrating potent activity with an EC50 of 3 nM. This compound has been designed for oral bioavailability and exhibits minimal allosteric agonist activity. Its primary applications include studies of dopaminergic signaling and potential therapeutic interventions in neurological disorders related to dopamine dysregulation.

Cat. No.

A59870

CAS No.

1354030-52-6

UNC9995

UNC9995 is a β-arrestin2-biased agonist of the dopamine receptor Drd2. This compound inhibits NLRP3 inflammasome activation by promoting the interaction between β-arrestin2 and NLRP3, thereby preventing neuronal degeneration. Furthermore, UNC9995 activates Drd2/β-arrestin2 signaling, which mitigates the transcription of inflammation-related genes induced by the JAK/STAT3 pathway. Research shows that UNC9995 enhances depressive behavior in mouse models and improves astrocyte dysfunctions, making it a valuable tool for studying neuroinflammatory processes and mood disorders.

Cat. No.

A59873

CAS No.

1434515-70-4

UCSF924

UCSF924 is a potent and selective partial agonist of the dopamine D4 receptor (DRD4), exhibiting an EC50 of 4.2 nM. This compound demonstrates no off-target effects on over 320 non-olfactory GPCRs, making it a valuable tool for research. UCSF924 is primarily used in studies related to neuropsychiatric disorders, facilitating a better understanding of the role of DRD4 in various neurological conditions.

Cat. No.

A59875

CAS No.

315698-36-3

MLS1547

MLS1547 is a potent G protein-biased agonist of the dopamine D2 receptor (D2R) with a Ki value of 1.2 μM. It effectively stimulates G protein-mediated signaling pathways, exhibiting an EC50 of 0.37 μM in calcium mobilization assays. Additionally, MLS1547 functions as an antagonist for dopamine-stimulated β-arrestin recruitment to the D2R, demonstrating an IC50 of 9.9 μM. This compound is valuable for investigating D2R signaling mechanisms and exploring therapeutic strategies for disorders associated with dopamine dysregulation.

Cat. No.

A59876

CAS No.

53772-83-1

Zuclopenthixol

Synonyms: (Z)-Clopenthixol

Zuclopenthixol is a thioxanthene derivative that functions as a mixed antagonist of dopamine D1 and D2 receptors. This compound has demonstrated antipsychotic properties and is primarily utilized in research related to neuropharmacology and the treatment of schizophrenia. Its ability to modulate dopaminergic signaling makes it a valuable tool for studying dopamine-related disorders and therapeutic interventions.

Cat. No.

A59878

CAS No.

2622-26-6

Pericyazine

Synonyms: Propericiazine; RP 8909

Pericyazine is a selective D2-dopamine receptor antagonist primarily utilized in the management of severe anxiety states and psychosis. This first-generation antipsychotic demonstrates key biological activities, including adrenolytic and anticholinergic effects, as well as potential extrapyramidal symptoms. Research applications of pericyazine extend to neuropharmacology, helping to elucidate the role of dopamine in psychiatric disorders.

Cat. No.

A59881

CAS No.

630117-19-0

PD-168077 maleate

PD-168077 maleate is a selective agonist targeting the dopamine D4 receptor, exhibiting a Ki value of 9 nM. This compound demonstrates the ability to activate dopamine signaling pathways, making it a valuable tool for research into neuropharmacology and psychiatric disorders. Its targeted mechanism is essential for studying the roles of dopamine receptor subtypes in various biological contexts.

Cat. No.

A59883

CAS No.

80751-85-5

SKF 83959

SKF 83959 is a selective partial agonist of the dopamine D1-like receptors, demonstrating Ki values of 1.18 nM for D1 and 7.56 nM for D5, while exhibiting lower affinity for D2 and D3 receptors at 920 nM and 399 nM, respectively. Additionally, SKF 83959 acts as a potent allosteric modulator of the sigma-1 receptor. This compound is primarily utilized in research focused on cognitive dysfunction, Alzheimer's disease, and depression, providing insights into potential therapeutic pathways.

Cat. No.

A59884

CAS No.

5002-47-1

Fluphenazine decanoate

Fluphenazine decanoate functions as a CNS-penetrant dopamine D2 receptor antagonist and is classified as a long-acting phenothiazine neuroleptic. This compound is primarily utilized in the study of schizophrenia and offers significant insights into dopaminergic pathways and neuropsychiatric disorders. Its prolonged action makes it a valuable tool for examining chronic treatment effects in preclinical research.

Cat. No.

A59888

CAS No.

73220-03-8

(S)-Remoxipride hydrochloride

Synonyms: (-)-Remoxipride hydrochloride

(S)-Remoxipride hydrochloride is a selective antagonist of the dopamine D2 receptor, exhibiting an IC50 value of 1.57 μM. This compound is primarily utilized in research related to psychotic disorders, aiding in the exploration of dopamine receptor pathways and their roles in neuropsychiatric conditions. Its specificity for the D2 receptor positions it as a valuable tool for studying schizophrenia and other related disorders.

Cat. No.

A59889

CAS No.

3520-14-7

D-Tetrahydropalmatine

D-Tetrahydropalmatine is an isoquinoline alkaloid that functions as a dopamine receptor antagonist, with a preferential affinity for D1 receptors. This compound exhibits significant inhibitory activity against organic cation transporter 1 (OCT1). D-Tetrahydropalmatine is utilized in research focused on neurological disorders and the modulation of dopamine signaling pathways. Its unique properties make it a valuable tool in the exploration of receptor interactions and pharmacological investigations.