Diacylglycerol Kinase (DGK) | Adooq Bioscience

Cat. No.: A70017

CAS No.: 3039488-69-9

DGK-IN-8

DGK-IN-8 is a specific inhibitor targeting diacylglycerol kinase (DGK) isoforms, including DGKα and DGKζ, with an IC50 value of ≤ 20 nM. This potent inhibitor is utilized in cancer research to investigate the role of DGK signaling in tumor growth and progression, providing insights into potential therapeutic strategies. Researchers can leverage DGK-IN-8 to explore the modulation of cellular signaling pathways influenced by diacylglycerol metabolism.

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Cat. No.: A70018

CAS No.: 2648723-43-5

DGKα-IN-4

DGKα-IN-4 is a selective diacylglycerol kinase alpha (DGKα) inhibitor with an IC50 of 0.1 nM. This compound enhances the anti-tumor efficacy of anti-PD-1 therapies by promoting T cell proliferation and function. DGKα-IN-4 is poised to advance research in the fields of oncology and immunology.

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Cat. No.: A70020

CAS No.: 3062708-86-2

DGKζ-IN-10

DGKζ-IN-10 is a selective inhibitor of diacylglycerol kinase zeta (DGKζ), exhibiting an IC50 of 200 nM or less. This compound is instrumental in research focused on the regulation of signaling pathways involving diacylglycerol, affecting various physiological processes. DGKζ-IN-10 is particularly useful for studies exploring the role of DGKζ in cell proliferation, differentiation, and apoptosis.

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Cat. No.: A70021

CAS No.: 2648418-86-2

DGKα-IN-3

DGKα-IN-3 is a potent inhibitor of diacylglycerol kinase alpha (DGKα), exhibiting an IC50 of 283 nM. This compound has been shown to significantly enhance the anti-tumor activity of anti-PD-1 therapies by promoting T cell proliferation and function. DGKα-IN-3 is a valuable tool for cancer and immunology research, providing insights into T cell modulation and potential therapeutic applications in tumor immunotherapy.

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Cat. No.: A70022

CAS No.: 2951002-04-1

DGKζ-IN-5

DGKζ-IN-5 is a highly selective inhibitor of diacylglycerol kinase zeta (DGKζ), which plays a crucial role in lipid signaling pathways. This compound is designed to modulate DGKζ activity, thereby impacting various cellular processes influenced by diacylglycerol levels. DGKζ-IN-5 can be utilized in research applications focusing on lipid metabolism, signal transduction, and related diseases, providing insights into the therapeutic potential of targeting DGKζ in various biological systems.

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Cat. No.: A70023

CAS No.: 2886734-91-2

DGKα-IN-6

DGKα-IN-6 is a selective inhibitor of diacylglycerol kinase alpha (DGKα), exhibiting an IC50 of 1.377 nM. This compound has demonstrated potential for use in cancer research, providing insights into the role of DGKα in tumor biology and signaling pathways. Researchers can utilize DGKα-IN-6 to explore its effects on cell proliferation and survival in various cancer models.

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Cat. No.: A70024

CAS No.: 3023735-55-6

DGK-IN-13

DGK-IN-13 is an inhibitor of diacylglycerol kinase (DGK), a key enzyme involved in lipid signaling pathways. This compound is utilized in cancer research to investigate the role of DGK in tumor growth and progression. By modulating DGK activity, DGK-IN-13 provides valuable insights into the mechanisms of cancer biology and potential therapeutic approaches.

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Cat. No.: A70026

CAS No.: 2830643-06-4

DGKα/ζ-IN-1

DGKα/ζ-IN-1 is a selective inhibitor of the diacylglycerol kinase (DGK) enzyme, specifically targeting DGKα and DGKζ. This compound is known to enhance T cell functionality, thereby promoting anti-tumor immune responses. Its synergistic effect with PD-1 blockade positions DGKα/ζ-IN-1 as a valuable tool for research in immunotherapy and tumor biology.

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Cat. No.: A70027

CAS No.: 3023735-35-2

DGK-IN-12

DGK-IN-12 is an inhibitor of diacylglycerol kinase (DGK), playing a crucial role in modulating cellular signaling pathways. This compound demonstrates significant biological activity in cancer research, particularly in studying tumor cell behavior and proliferation. DGK-IN-12 is valuable for exploring the therapeutic potential of DGK inhibition in various cancer models.

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Cat. No.: A70028

CAS No.: 3062706-10-6

DGKζ-IN-9

DGKζ-IN-9 is a specific inhibitor of diacylglycerol kinase ζ (DGKζ), exhibiting an IC50 of 200 nM or lower. This compound effectively modulates intracellular signaling pathways by preventing the conversion of diacylglycerol to phosphatidic acid. DGKζ-IN-9 is valuable for research investigating the role of DGKζ in various cellular processes and its potential implications in disease models.

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Cat. No.: A70029

CAS No.: 93076-87-0

JNJ-3790339

JNJ-3790339 is a selective inhibitor of diacylglycerol kinase alpha (DGKα), exhibiting an IC50 of 9.6 μM. This compound demonstrates the ability to induce cytotoxicity in malignant cells while enhancing T cell activation. JNJ-3790339 serves as a valuable tool for studying immune responses and potential cancer therapies.

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Cat. No.: A70030

CAS No.: 2886092-50-6

DGKα-IN-7

DGKα-IN-7 is a selective inhibitor of diacylglycerol kinase alpha (DGKα) with an IC50 of 6.225 nM. This compound is significant in cancer research, as it modulates signaling pathways that can impact tumor progression and cellular proliferation. DGKα-IN-7 may serve as a valuable tool for investigating the role of DGKα in various cancer-related studies.

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