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Soluble epoxide hydrolase (sEH) inhibitors block the hydrolysis of epoxy fatty acids to their diols. The enzyme converts epoxyeicosatrienoic acids (EETs), vasodilatory lipid mediators made from arachidonic acid by cytochrome P450 enzymes, into less active dihydroxy acids. Blocking sEH raises EET levels, so inhibitors are used in studies of blood pressure, vascular inflammation and pain. Urea-based inhibitors listed in this section include TPPU, AUDA, AR-9281 and GSK2256294A. The section also holds dual inhibitors of sEH and histone deacetylase 6 (HDAC6), such as sEH/HDAC6-IN-1.
sEH inhibitor-2 is a potent soluble epoxide hydrolase (sEH) inhibitor with an IC50 value of 0.9 nM. It demonstrates high oral bioavailability and effectively maintains elevated serum levels of epoxyeicosatrienoic acids (EETs). This compound is essential for investigating mechanisms of cardiovascular protection and related therapeutic applications.
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4H-Tomentosin is a mixed-competitive inhibitor of soluble epoxide hydrolase (sEH), demonstrating an IC50 of 6.84 μM and a Ki value of 7.02 μM. This compound interacts with the sEH enzyme through hydrogen bonding with key residues such as Tyr343, Ile363, and Tyr383. Its ability to effectively inhibit sEH makes it a valuable tool for research into lipid signaling pathways and the modulation of inflammatory responses.
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Arabinothalictoside is a selective inhibitor of soluble epoxide hydrolase (sEH), exhibiting an IC50 value of 47.1 µM. It is derived from the plant species Annona squamosa L. and plays a significant role in regulating lipid metabolism. This compound is valuable in research studies focused on cardiovascular and urinary diseases, facilitating investigations into pathways associated with epoxide-mediated signaling.
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N-(3-Methoxybenzyl)stearamide is an epoxide hydrolase inhibitor that effectively inhibits human and mouse soluble epoxide hydrolase (hsEH and msEH) with IC50 values of 0.001 and
Soluble epoxide hydrolase inhibitor targets soluble epoxide hydrolase (sEH) and demonstrates potent inhibition of human soluble epoxide hydrolase (h-sEH) with a pIC50 of 8.4. This compound plays a critical role in modulating the levels of epoxyeicosatrienoic acids (EETs) and is valuable in research applications related to cardiovascular and inflammatory diseases. Its inhibition can enhance cannabinoid signaling pathways, making it a useful tool for studying the effects of eicosanoids in various biological contexts.
sEH inhibitor-5 is a highly potent soluble epoxide hydrolase (sEH) inhibitor, demonstrating an IC50 value of 0.1 nM. Its primary mechanism involves the selective inhibition of the sEH enzyme, which plays a crucial role in regulating eicosanoid metabolism. This compound is valuable for research applications investigating the modulation of inflammation and cardiovascular function, making it an essential tool for studies related to metabolic disorders and vascular health.
