Glucosidase

Cat. No.

A75190

CAS No.

3012673-89-8

α-Glucosidase-IN-41

α-Glucosidase-IN-41 is a potent inhibitor of α-glucosidase, functioning by altering the secondary structure of the enzyme to impede its catalytic activity. This compound is valuable in research focused on diabetes mellitus, providing insights into carbohydrate metabolism and potential therapeutic strategies. Its efficacy in modulating enzyme activity makes it a pertinent tool for studying glycemic control and related metabolic disorders.

Cat. No.

A75191

CAS No.

194940-15-3

(E)-p-Coumaramide

(E)-p-Coumaramide acts as an α-Glucosidase inhibitor, playing a significant role in carbohydrate metabolism regulation. This compound, which can be isolated from Welsh onion, demonstrates potential biological activity in managing glucose levels and may contribute to diabetes research. Its application extends to studies aimed at understanding the mechanisms of glycosidase enzymes in metabolic disorders.

Cat. No.

A75192

CAS No.

2734265-58-6

5-C-phenethyl-DNJ

5-C-phenethyl-DNJ is a selective α-glucosidase inhibitor, targeting glycosylation pathways with a Ki value of 0.81 μM for recombinant human acid α-glucosidase (rhGAA). This compound demonstrates notable selectivity for glycosyltransferases GANAB, GBA1, and GBA2. 5-C-phenethyl-DNJ is particularly valuable in the research of Pompe disease, enabling insights into enzymatic deficiencies and potential therapeutic strategies.

Cat. No.

A75193

CAS No.

1422390-59-7

2'-Rhamnoechinacoside

Synonyms: Michelioside A

2'-Rhamnoechinacoside (Michelioside A) is an α-glucosidase inhibitor derived from Phlomis stewartii, demonstrating notable anti-tumor activity. This phenylethanoid glycoside can be utilized in research focused on UV absorption and cancer biology, offering insights into therapeutic strategies against glucose-related disorders. Its mechanism of action and biological activity make it a valuable tool for studying metabolic processes and developing potential cancer treatments.

Cat. No.

A75194

CAS No.

252351-96-5

Lucidal

Synonyms: Lucialdehyde C

Lucidal is a natural lanosto-type triterpene aldehyde that functions as an inhibitor of α-glucosidase, exhibiting an IC50 of 0.635 mM. This compound demonstrates significant biological activities, including anticancer and antidiabetic effects. It is useful for research applications targeting metabolic disorders and cancer biology.

Cat. No.

A75195

CAS No.

1830306-93-8

Giffonin P

Giffonin P is a selective inhibitor of α-glucosidase, exhibiting an IC50 value of 55.3 μM. This compound effectively delays carbohydrate hydrolysis and glucose absorption, contributing to its anti-hyperglycemic properties. Giffonin P is primarily utilized in research related to type 2 diabetes, particularly in studies focused on managing postprandial blood glucose levels.

Cat. No.

A75197

CAS No.

2448345-96-6

α-Glucosidase-IN-8

α-Glucosidase-IN-8 is a potent competitive inhibitor of α-glucosidase, exhibiting an IC50 value of 0.18 µg/mL. This compound effectively blocks the enzymatic activity of α-glucosidase, which plays a crucial role in carbohydrate metabolism. Its primary applications include studying glucose absorption and management of conditions like diabetes, making it valuable for research in metabolic disease and pharmacology.

Cat. No.

A75198

CAS No.

3025234-94-7

α-Glucosidase-IN-36

α-Glucosidase-IN-36 is a selective inhibitor of α-glucosidase, exhibiting an IC50 value of 6.69 ± 0.18 μM and Ki and Kis values of 1.65 μM and 4.54 μM, respectively. This compound functions by binding to the active site of α-glucosidase, leading to alterations in its secondary structure, which subsequently inhibits enzyme activity. α-Glucosidase-IN-36 is valuable for research applications related to type 2 diabetes mellitus (T2DM), enabling investigations into carbohydrate metabolism and glycemic control.

Cat. No.

A75199

CAS No.

104343-33-1

MDL-25637

MDL-25637 is an α-glucosidase inhibitor that effectively inhibits the activity of enzymes such as sucrose, maltase, isomaltase, glucose amylase, and trehalose in the intestinal tract. This compound is primarily utilized in diabetes research to investigate the regulation of carbohydrate absorption and its implications for glucose homeostasis. Its ability to modulate enzymatic activity makes it a valuable tool for studying metabolic disorders associated with diabetes.

Cat. No.

A75200

CAS No.

329783-03-1

α-Amylase/α-Glucosidase-IN-1

α-Amylase/α-Glucosidase-IN-1 is a potent inhibitor of both α-amylase and α-glucosidase, exhibiting IC50 values of 2.01 µM and 2.09 µM, respectively. This compound is utilized in biochemical research to investigate mechanisms of glycemic control and has potential applications in the management of hyperglycemia. The inhibitory activity of α-Amylase/α-Glucosidase-IN-1 makes it a valuable tool for studying carbohydrate metabolism and related metabolic disorders.

Cat. No.

A75203

CAS No.

2477746-26-0

Mortatarin G

Mortatarin G is a prenylated flavonoid that functions as an α-glucosidase inhibitor. It demonstrates significant inhibitory activity against α-glucosidase, with an IC50 value of 20.4±1.4 μM. This compound is useful for research applications focused on carbohydrate metabolism and potential therapeutic strategies for managing diabetes and related metabolic disorders.

Cat. No.

A75204

CAS No.

2758286-48-3

α-Glucosidase-IN-3

α-Glucosidase-IN-3 is an oleanolic acid oxime ester derivative that acts as an inhibitor of α-glucosidase, exhibiting an IC50 value of 0.35 µM. This compound also demonstrates inhibitory activity against α-amylase, making it a valuable tool for studies focused on carbohydrate metabolism. Its potential applications include investigating the mechanisms of diabetes management and exploring the therapeutic effects of glycosidase inhibition in metabolic disorders.

Cat. No.

A75205

CAS No.

2949513-10-2

α-Glucosidase-IN-28

α-Glucosidase-IN-28 is a potent α-glucosidase inhibitor, exhibiting an IC50 of 0.62 μM and a Ki of 3.93 μM. This compound selectively binds to the original binding site of α-glucosidase, engaging in multiple hydrophobic interactions with adjacent amino acids. α-Glucosidase-IN-28 is primarily utilized in research related to diabetes and its associated metabolic disorders, providing valuable insights into glucose regulation and enzyme modulation.

Cat. No.

A75206

CAS No.

2820424-85-7

α-Glucosidase-IN-15

α-Glucosidase-IN-15 is a potent inhibitor of α-glucosidase, demonstrating an IC50 value of 3.34 μM. This compound exhibits significant antidiabetic activity by preventing the hydrolysis of carbohydrates, thereby reducing postprandial blood glucose levels. It is suitable for research applications focused on diabetes management and metabolic disorders.

Cat. No.

A75209

CAS No.

1444411-75-9

Kouitchenside G

Kouitchenside G is a natural inhibitor of α-Glucosidase, isolated from the plant Swertia kouitchensis. It demonstrates inhibitory activity with an IC50 value of 956 μM, making it a valuable tool for studying carbohydrate metabolism and enzyme modulation. This compound is pertinent for research applications focused on diabetes and metabolic disorders.

Cat. No.

A75210

CAS No.

2259327-01-8

Resinacein L

Resinacein L is a potent inhibitor of α-glucosidase, exhibiting an IC50 value of 0.635 mM. By impeding the digestion and absorption of carbohydrates in the gastrointestinal tract, Resinacein L effectively reduces postprandial blood glucose levels. This compound is valuable in research applications focused on diabetes management and the study of carbohydrate metabolism.

Cat. No.

A75213

CAS No.

170376-12-2

Glycosidase-IN-1

Glycosidase-IN-1 is a glycosidase inhibitor derived from D-mannose. This compound exhibits hypoglycemic activity and holds potential for the synthesis of immunosuppressive agents and β-glucosidase inhibitors. Its ability to modulate glycosidase activity makes it a valuable tool in biochemical research focused on carbohydrate metabolism and related diseases.

Cat. No.

A75214

CAS No.

2586282-68-8

α-Glucosidase-IN-10

α-Glucosidase-IN-10 is a potent inhibitor of α-glucosidase, exhibiting an IC50 value of 92.7 μM. This compound serves as a valuable tool for investigating the modulation of carbohydrate metabolism and is particularly relevant for research in type II diabetes. Its ability to effectively inhibit α-glucosidase makes it suitable for studies focused on glucose absorption regulation and diabetes management strategies.

Cat. No.

A75215

CAS No.

22567-38-0

Bisabolone oxide A

Bisabolone oxide A is an α-glucosidase inhibitor that modulates carbohydrate metabolism by delaying the absorption of glucose in the intestine. This compound demonstrates significant potential in research applications related to diabetes management and glycemic control. Its ability to influence α-glucosidase activity makes it a valuable tool for studies focused on metabolic disorders and enzymatic regulation.

Cat. No.

A75216

CAS No.

2820424-84-6

α-Glucosidase-IN-17

α-Glucosidase-IN-17 is a potent inhibitor of α-glucosidase, displaying an IC50 value of 3.79 μM. This compound demonstrates significant antidiabetic activity, making it a valuable research tool for studying the regulation of carbohydrate metabolism and the management of diabetes. It can be utilized in pharmacological studies aimed at exploring the modulation of blood glucose levels.

Cat. No.

A75217

CAS No.

321686-01-5

α-Glucosidase-IN-21

α-Glucosidase-IN-21 is a potent inhibitor of α-glucosidase, demonstrating an IC50 of 2.62 μM. This compound exhibits significant anti-diabetic activity, making it valuable for research into glycemic control and obesity-related metabolic disorders. Its efficacy as an α-glucosidase inhibitor supports its use in studies targeting carbohydrate metabolism and related therapeutic applications.

Cat. No.

A75218

CAS No.

420809-56-9

α-Glucosidase-IN-20

α-Glucosidase-IN-20 is a potent orally active inhibitor of α-glucosidase, with an IC50 value of 3.01 μM. This compound demonstrates significant anti-diabetic activity by modulating carbohydrate metabolism and reducing postprandial glucose levels. It is suitable for research applications aimed at exploring therapeutic strategies for managing type 2 diabetes and related metabolic disorders.

Cat. No.

A75220

CAS No.

72691-72-6

(+)-Cembrene A (d-Cembrene A)

Synonyms: d-Cembrene A

(+)-Cembrene A is an α-glucosidase inhibitor, exhibiting an IC50 of 30.31 μM. This compound demonstrates nontoxicity towards human normal hepatocyte (LO2) cells, making it a suitable candidate for research in metabolic disorders and carbohydrate metabolism regulation. Its ability to modulate α-glucosidase activity suggests potential applications in studies focused on diabetes and related pathophysiological conditions.

Cat. No.

A75221

CAS No.

919364-56-0

Afegostat tartrate

Synonyms: AT 2101; D-Isofagomine tartrate; Isofagomine tartrate

Afegostat tartrate is a potent glucosidase inhibitor that selectively binds to acid-β-glucosidase (GCase) within the endoplasmic reticulum, functioning as a pharmacological chaperone. This compound enhances enzyme stability and promotes proper folding, making it valuable for research related to Gaucher disease and other lysosomal storage disorders. Its ability to influence GCase activity makes it an important tool for studies aimed at understanding enzyme deficiencies and developing therapeutic strategies.

Cat. No.

A75222

CAS No.

24672-84-2

α-Glucosidase-IN-35

α-Glucosidase-IN-35 is a chromene that functions as a potent inhibitor of α-glucosidase, exhibiting an IC50 value of 0.169 mg/mL. Isolated from the aqueous extract of the aerial parts of Brickellia cavanillesii, this compound is valuable in studies targeting carbohydrate metabolism and diabetes research. Its application may facilitate the exploration of α-glucosidase inhibition as a therapeutic strategy in metabolic disorders.