Glucosidase

Cat. No.

A75152

CAS No.

2870693-28-8

α-Glucosidase-IN-22

α-Glucosidase-IN-22 is a benzimidazole derivative that serves as a potent inhibitor of α-glucosidase, exhibiting an IC50 value of 0.64 μM. This compound demonstrates significant anti-diabetic properties, making it a promising candidate for research in type 2 diabetes mellitus (T2DM). Its ability to modulate carbohydrate digestion positions α-Glucosidase-IN-22 as a valuable tool in glucose metabolism studies and diabetes management investigations.

Cat. No.

A75154

CAS No.

202979-51-9

L-Afegostat

Synonyms: 5-epi-Isofagomine

L-Afegostat (5-epi-Isofagomine) is a glycosidase inhibitor that targets β-Glucosidase, exhibiting enzyme inhibition with a Ki of 30 μM. This iminosugar plays a significant role in carbohydrate synthesis and is valuable for studying glycosidase-related metabolic processes. It is particularly useful in research focused on enzyme regulation and glycosylation mechanisms.

Cat. No.

A75155

CAS No.

3018963-27-1

α-Glucosidase-IN-43

α-Glucosidase-IN-43 is a potent α-glucosidase inhibitor with an IC50 value of 4.32 μM, demonstrating significant hypoglycemic activity. This compound exhibits low toxicity in normal mouse fibroblasts and shows efficacy in vivo, effectively rescuing streptozotocin-induced diabetic rats. α-Glucosidase-IN-43 is valuable for investigating postprandial hyperglycemia and related metabolic disorders in diabetes research.

Cat. No.

A75156

CAS No.

5041-66-7

Quercetin 3'-methoxy-3-O-α-L-arabinofuranoside

Quercetin 3'-methoxy-3-O-α-L-arabinofuranoside is an α-glucosidase inhibitor, derived from the leaves and twigs of Fagus hayatae. This compound demonstrates weak inhibitory activity against α-glucosidase, an enzyme involved in carbohydrate metabolism. It serves as a valuable tool for research in glycemic control and metabolic studies.

Cat. No.

A75158

CAS No.

2488372-34-3

Anti-hyperglycemic agent-1

Anti-hyperglycemic agent-1 is a potent α-Glucosidase inhibitor, exhibiting an IC50 of 0.53 μM. This compound is primarily utilized in diabetes research to investigate mechanisms of glucose metabolism and control postprandial hyperglycemia. Its selective inhibition of α-Glucosidase makes it a valuable tool for studying the biochemical pathways involved in carbohydrate absorption and insulin sensitivity.

Cat. No.

A75160

CAS No.

1809429-26-2

Falandioside B

Falandioside B is an α-glucosidase inhibitor with an IC50 of 107.52 μM, effectively modulating carbohydrate metabolism. It exhibits antioxidant activity by scavenging ABTS radical cations, making it relevant for studies on oxidative stress. This compound is primarily utilized in research focused on managing postprandial hyperglycemia and its associated metabolic implications.

Cat. No.

A75161

CAS No.

735273-33-3

α-Glucosidase-IN-9

α-Glucosidase-IN-9 is a potent inhibitor of α-glucosidase, exhibiting an IC50 of 55.6 μM. This compound is relevant for research applications focused on type II diabetes, enabling the investigation of carbohydrate digestion and glucose absorption. Through its inhibitory action, α-Glucosidase-IN-9 provides a valuable tool for studying the metabolic implications associated with dysregulated glucose homeostasis.

Cat. No.

A75164

CAS No.

2832824-40-3

EB-0150

EB-0150 is a selective inhibitor of endoplasmic reticulum α-glucosidases I and II, exhibiting IC50 values of 0.73 µM and 0.0337 µM, respectively. This N-substituted derivative of valiolamine demonstrates broad-spectrum antiviral activity and can be utilized in research aimed at developing agents against both existing and emerging viral pathogens. Additionally, EB-0150 serves as a versatile click chemistry reagent, possessing an azide group that enables copper-catalyzed azide-alkyne cycloaddition (CuAAc) and strain-promoted alkyne-azide cycloaddition (SPAAC) with alkyne-containing and DBCO or BCN-labeled molecules.

Cat. No.

A75166

CAS No.

1622982-59-5

6,8-Dihydroxy-1,2,7-trimethoxy-3-methylanthraquinone

6,8-Dihydroxy-1,2,7-trimethoxy-3-methylanthraquinone is an anthraquinone that serves as an α-glucosidase inhibitor, exhibiting an IC50 value of 185 μM. This compound, which can be isolated from Cassia seeds, is valuable for investigating carbohydrate metabolism and potential therapeutic applications in managing diabetes. Its inhibitory activity makes it a suitable candidate for research focused on the modulation of glucose absorption.

Cat. No.

A75167

CAS No.

1801934-15-5

Ganoderlactone D

Ganoderlactone D is a potent inhibitor of α-Glucosidase, demonstrating an IC50 value of 41.7 μM in yeast models. This compound is utilized in research to explore its potential effects on carbohydrate metabolism and its role in the management of postprandial hyperglycemia. Its inhibitory action provides a valuable tool for studying the modulation of glucose absorption and its implications in diabetes research.

Cat. No.

A75168

CAS No.

132282-70-3

(2α,3β,4α)-2,3,19-Trihydroxyurs-12-ene-23,28-dioic acid

(2α,3β,4α)-2,3,19-Trihydroxyurs-12-ene-23,28-dioic acid is a natural saponin extracted from Rubus ellipticus var. obcordatus that acts as an α-Glucosidase inhibitor. This compound exhibits an inhibitory activity with an IC50 of 1.68 mM, making it a valuable tool for research focused on carbohydrate metabolism and diabetes management. Its biological properties facilitate studies exploring the regulation of glucose absorption and potential therapeutic approaches in glycemic control.

Cat. No.

A75169

CAS No.

2820424-81-3

α-Glucosidase-IN-18

α-Glucosidase-IN-18 is a potent inhibitor of α-glucosidase, exhibiting an IC50 value of 3.96 μM. This compound demonstrates significant antidiabetic activity, making it a valuable tool for research in glucose metabolism and diabetes treatment. Its oral bioavailability supports its potential applications in pharmacological studies targeting carbohydrate digestion and postprandial blood glucose regulation.

Cat. No.

A75171

CAS No.

161187-57-1

α-Glucosidase-IN-23

α-Glucosidase-IN-23 is a potent inhibitor of α-glucosidase, demonstrating an IC50 value of 4.48 μM. This compound effectively lowers blood glucose levels by inhibiting the enzyme α-glucosidase, making it a valuable tool in diabetes research. α-Glucosidase-IN-23 is suitable for studies focused on glucose metabolism and the development of therapeutic strategies for diabetes management.

Cat. No.

A75173

CAS No.

26788-86-3

α-Glucosidase-IN-56

α-Glucosidase-IN-56 is a potent inhibitor of α-glucosidase, with an IC50 value of 45.86 μM. This compound exhibits significant anti-glycation activity, making it a valuable tool for research in the fields of diabetes and metabolic disorders. Its ability to inhibit carbohydrate digestion positions it as a candidate for further studies aimed at understanding and managing glycemic responses.

Cat. No.

A75174

CAS No.

2816072-18-9

α-Glucosidase-IN-13

α-Glucosidase-IN-13 is an α-glucosidase inhibitor, demonstrating an IC50 value of 5.69 μM. This compound effectively interferes with the enzyme's activity, making it a valuable tool for studying carbohydrate metabolism and the regulation of blood glucose levels. Its applications extend to diabetes research and the development of therapeutic strategies targeting glycemic control.

Cat. No.

A75175

CAS No.

2966859-35-6

α-Glucosidase-IN-30

α-Glucosidase-IN-30 is a competitive inhibitor of α-glucosidase, exhibiting a Ki value of 40.0 µM and an IC50 of 49.0 µM. This reagent demonstrates non-cytotoxicity in both cancer (MCF-7) and normal (HDF) cell lines, making it suitable for research applications in Type 2 diabetes studies. Its oral bioactivity and selectivity position it as an important tool for exploring therapeutic interventions targeting carbohydrate metabolism.

Cat. No.

A75177

CAS No.

3093893-44-5

α-Glucosidase-IN-100

α-Glucosidase-IN-100 is a potent inhibitor of α-glucosidase, a key enzyme involved in carbohydrate metabolism. This compound is instrumental in exploring metabolic disorders, particularly diabetes, by modulating glucose absorption and metabolism. Its use in research may provide insights into therapeutic strategies for managing hyperglycemia and associated metabolic conditions.

Cat. No.

A75178

CAS No.

38231-86-6

Valienamine

Valienamine is an alpha-glucosidase inhibitor that plays a crucial role in the regulation of carbohydrate metabolism. This compound is a fundamental structural component of various natural glycosidase inhibitors, including the agricultural fungicide validamycin A and the antidiabetic drug acarbose. Valienamine is primarily utilized in research applications focused on diabetes management and crop protection strategies.

Cat. No.

A75179

CAS No.

2366153-27-5

1,6,8-Trihydroxy-2,7-dimethoxy-3-methylanthraquinone

1,6,8-Trihydroxy-2,7-dimethoxy-3-methylanthraquinone is a potent α-glucosidase inhibitor isolated from Cassia obtusefolia. It demonstrates a significant inhibitory effect with an IC50 value of 120.65 μg/mL. This compound is valuable for research into diabetic mechanisms and potential therapeutic interventions. Its efficacy in modulating carbohydrate metabolism makes it a useful tool in the study of metabolic disorders.

Cat. No.

A75181

CAS No.

2758286-53-0

α-Amylase-IN-2

α-Amylase-IN-2 is an oleanolic acid oxime ester derivative that acts as a potent α-glucosidase inhibitor, exhibiting an IC50 value of 1.28 µM. Additionally, it demonstrates inhibitory activity against α-amylase with an IC50 of 3.8 µM. This compound is valuable for research applications focused on metabolic disorders such as diabetes, where modulation of carbohydrate digestion is critical.

Cat. No.

A75183

CAS No.

87797-84-0

6β-Hydroxyipolamiide

6β-Hydroxyipolamiide is an α-glucosidase inhibitor identified in the methanolic extract of S. jamaicensis leaves. It demonstrates significant inhibitory activity with an IC50 of 539.17 μg/mL. This compound is relevant for research focused on carbohydrate metabolism and the management of conditions related to glycemic control.

Cat. No.

A75186

CAS No.

1624628-01-8

α-Glucosidase-IN-68

α-Glucosidase-IN-68 is a selective inhibitor of α-glucosidase, demonstrating an IC50 of 0.251 μM, along with inhibition of AChE and BChE at 0.774 μM and 0.793 μM, respectively. This compound exhibits strong antioxidant properties, with IC50 values of 0.69 μM in the DPPH assay and 0.02 μM in the ABTS assay. Additionally, α-Glucosidase-IN-68 has been shown to have an antidiabetic effect in streptozotocin-induced diabetic rat models, making it a valuable tool for research in diabetes and related metabolic disorders.

Cat. No.

A75187

CAS No.

2699784-18-2

α-Glucosidase-IN-2

α-Glucosidase-IN-2 is a potent inhibitor of α-Glucosidase, exhibiting an IC50 of 9.48 µM. This compound demonstrates significant antidiabetic activity by impeding carbohydrate digestion and absorption, thereby lowering postprandial blood glucose levels. It serves as a valuable tool for research in diabetes management and metabolic studies.

Cat. No.

A75188

CAS No.

1010804-67-7

Timosaponin N

Timosaponin N is a natural steroidal saponin that acts as an inhibitor of α-Glucosidase. Its primary mechanism involves reducing glucose absorption in the intestine, making it an important research tool in studies related to diabetes and glycemic control. Timosaponin N may provide insights into therapeutic pathways for managing blood sugar levels in diabetic patients.

Cat. No.

A75189

CAS No.

2446063-14-3

α-Amylase/α-Glucosidase-IN-2

α-Amylase/α-Glucosidase-IN-2 is a potent dual inhibitor of α-amylase and α-glucosidase, demonstrating IC50 values of 13.02 µM and 13.09 µM, respectively. This compound is primarily utilized in research investigating diabetic complications, offering significant insights into glucose metabolism and potential therapeutic strategies for managing diabetes. Its dual mechanism of action makes it a valuable tool for studying carbohydrate digestion and its implications in hyperglycemia.