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$0.00 Neurokinin Receptors
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Serlopitant
Catalog No. A21582 Neurokinin-1 (NK-1) receptor antagonistSerlopitant is a selective Neurokinin-1 (NK-1) receptor antagonist. Learn More -
Vofopitant dihydrochloride
Catalog No. A21543 NK1 receptor antagonistVofopitant dihydrochloride (GR 205171A) is a potent, selective and orally available tachykinin neurokinin 1(NK1) receptor antagonist. Learn More -
Maropitant
Catalog No. A21473 NK1 receptor antagonistMaropitant is a neurokinin (NK1) receptor antagonist. Learn More -
Pavinetant
Catalog No. A21174 NK3R antagonistPavinetant (MLE-4901) is a neurokinin-3 receptor (NK3R) antagonist. Learn More -
Befetupitant
Catalog No. A13149 NK1R antagonistBefetupitant is a high-affinity, nonpeptide, competitive tachykinin 1 receptor (NK1R) antagonist. Learn More -
Tradipitant
Catalog No. A16918 NK1 receptor antagonistTradipitant, also known as VLY-686 and LY686017, is the 2nd generation neurokinin-1 receptor antagonist, which showed activity in preclinical anxiety models. Learn More -
Senktide
Catalog No. A16945 NK3 receptor agonistSenktide is a potent, selective agonist of the neuromedin K3 (NK3) receptor (EC50 = 0.5-3 nM). Learn More -
SB-222200
Catalog No. A15230 NK3 receptor antagonistSB 222200 is a selective, reversible and competitive antagonist of human NK-3 receptor(Ki=4.4 nM) that effectively crosses the blood-brain barrier. Learn More -
Talnetant hydrochloride
Catalog No. A15255 NK3 receptor antagonistTalnetant Hcl is a potent and selective NK3 receptor antagonist(ki=1.4 nM, hNK-3-CHO); 100-fold selective for the hNK-3 versus hNK-2 receptor, with no affinity for the hNK-1 at concentrations up to 100 uM. Learn More -
Talnetant
Catalog No. A15254 NK3 receptor antagonistTalnetant is a potent and selective NK3 receptor antagonist(ki=1.4 nM, hNK-3-CHO); 100-fold selective for the hNK-3 versus hNK-2 receptor, with no affinity for the hNK-1 at concentrations up to 100 uM. Learn More -
Aprepitant (MK-0869)
Catalog No. A10083 neurokinin-1 receptor antagonistAprepitant is classified as an NK1 antagonist. Aprepitant has been shown to inhibit both the acute and delayed emesis induced by cytotoxic chemotherapeutic drugs by blocking substance P landing on receptors in the brains neurons. It has also been shown to increase the activity of the 5-HT3 receptor antagonists ondansetron and the corticosteroid dexamethasone, which are also used to prevent nausea and vomiting caused by chemotherapy.
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NKP608
Catalog No. A15187 NK1 receptor antagonistNKP608 is a non-peptidic derivative of 4-aminopiperidine which acts as a selective, specific and potent antagonist at the neurokinin-1 (NK-1) receptor both in vitro(IC50=2.6 nM) and in vivo. Learn More -
Netupitant
Catalog No. A14428 NK1 receptor antagonistNetupitant is a selective neurokinin 1 (NK1) receptor antagonist. It competitively binds to and blocks the activity of the human substance P/NK1 receptors in the central nervous system (CNS), thereby inhibiting NK1-receptor binding of the endogenous tachykinin neuropeptide substance P (SP), which may result in the prevention of chemotherapy-induced nausea and vomiting (CINV). Learn More -
GR-203040
Catalog No. A13861 NK1 receptor antagonistGR203040 is a novel, potent and selective non-peptide tachykinin NK1 receptor antagonist. Learn More -
Rolapitant
Catalog No. A13680 NK1 receptor antagonistRolapitant, also known as SCH-619734, is a selective, bioavailable, CNS penetrant neurokinin NK1 receptor antagonist that shows behavioral effects in animals models of emesis. Learn More -
Fosaprepitant dimeglumine
Catalog No. A11069 neurokinin-1 receptor antagonistFosaprepitant is a selective neurokinin-1 (NK-1) receptor antagonist. Learn More -
Ibodutant (MEN 15596)
Catalog No. A13104 tachykinin NK2 receptor antagonistIbodutant is a tachykinin NK2 receptor antagonist for the treatment of Irritable Bowel Syndrome with diarrhoea (IBS-D) Learn More -
GW679769 (Casopitant)
Catalog No. A13103 NK1 receptor antagonistCasopitant mesylate is the mesylate salt of a centrally-acting neurokinin 1 (NK1) receptor antagonist with antidepressant and antiemetic activities. Learn More -
Vofopitant (GR 205171)
Catalog No. A12793 NK1 receptor antagonistGR 205171 is a selective neurokinin-1 receptor antagonist Learn More -
MK-0517 (Fosaprepitant)
Catalog No. A11756 neurokinin-1 receptor antagonistFosaprepitant (MK-0517, L-758,298) is a water-soluble phosphoryl prodrug for Aprepitant which is a NK1 antagonist. Learn More
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