Neurokinin Receptors

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  1. Aprepitant (MK-0869)

    Catalog No. A10083
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    neurokinin-1 receptor antagonist

    Aprepitant is classified as an NK1 antagonist. Aprepitant has been shown to inhibit both the acute and delayed emesis induced by cytotoxic chemotherapeutic drugs by blocking substance P landing on receptors in the brains neurons. It has also been shown to increase the activity of the 5-HT3 receptor antagonists ondansetron and the corticosteroid dexamethasone, which are also used to prevent nausea and vomiting caused by chemotherapy.

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  2. Talnetant

    Catalog No. A15254
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    NK3 receptor antagonist
    Talnetant is a potent and selective NK3 receptor antagonist(ki=1.4 nM, hNK-3-CHO); 100-fold selective for the hNK-3 versus hNK-2 receptor, with no affinity for the hNK-1 at concentrations up to 100 uM. Learn More
  3. SB-222200

    Catalog No. A15230
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    NK3 receptor antagonist
    SB 222200 is a selective, reversible and competitive antagonist of human NK-3 receptor(Ki=4.4 nM) that effectively crosses the blood-brain barrier. Learn More
  4. NKP608

    Catalog No. A15187
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    NK1 receptor antagonist
    NKP608 is a non-peptidic derivative of 4-aminopiperidine which acts as a selective, specific and potent antagonist at the neurokinin-1 (NK-1) receptor both in vitro(IC50=2.6 nM) and in vivo. Learn More
  5. Netupitant

    Catalog No. A14428
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    NK1 receptor antagonist
    Netupitant is a selective neurokinin 1 (NK1) receptor antagonist. It competitively binds to and blocks the activity of the human substance P/NK1 receptors in the central nervous system (CNS), thereby inhibiting NK1-receptor binding of the endogenous tachykinin neuropeptide substance P (SP), which may result in the prevention of chemotherapy-induced nausea and vomiting (CINV). Learn More
  6. GR-203040

    Catalog No. A13861
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    NK1 receptor antagonist
    GR203040 is a novel, potent and selective non-peptide tachykinin NK1 receptor antagonist. Learn More
  7. Rolapitant

    Catalog No. A13680
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    NK1 receptor antagonist
    Rolapitant, also known as SCH-619734, is a selective, bioavailable, CNS penetrant neurokinin NK1 receptor antagonist that shows behavioral effects in animals models of emesis. Learn More
  8. Fosaprepitant dimeglumine

    Catalog No. A11069
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    neurokinin-1 receptor antagonist
    Fosaprepitant is a selective neurokinin-1 (NK-1) receptor antagonist. Learn More
  9. Ibodutant (MEN 15596)

    Catalog No. A13104
    tachykinin NK2 receptor antagonist
    Ibodutant is a tachykinin NK2 receptor antagonist for the treatment of Irritable Bowel Syndrome with diarrhoea (IBS-D) Learn More
  10. GW679769 (Casopitant)

    Catalog No. A13103
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    NK1 receptor antagonist
    Casopitant mesylate is the mesylate salt of a centrally-acting neurokinin 1 (NK1) receptor antagonist with antidepressant and antiemetic activities. Learn More
  11. Vofopitant (GR 205171)

    Catalog No. A12793
    NK1 receptor antagonist
    GR 205171 is a selective neurokinin-1 receptor antagonist Learn More
  12. MK-0517 (Fosaprepitant)

    Catalog No. A11756
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    neurokinin-1 receptor antagonist
    Fosaprepitant (MK-0517, L-758,298) is a water-soluble phosphoryl prodrug for Aprepitant which is a NK1 antagonist. Learn More
  13. Talnetant hydrochloride

    Catalog No. A15255
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    NK3 receptor antagonist
    Talnetant Hcl is a potent and selective NK3 receptor antagonist(ki=1.4 nM, hNK-3-CHO); 100-fold selective for the hNK-3 versus hNK-2 receptor, with no affinity for the hNK-1 at concentrations up to 100 uM. Learn More

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