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- Kodji X, .et al. Sensory nerves mediate spontaneous behaviors in addition to inflammation in a murine model of psoriasis, FASEB J, 2018, Sep 11:fj201800395RR PMID: 30204499
Biological Activity
Aprepitant is classified as an NK1 antagonist. Aprepitant has been shown to inhibit both the acute and delayed emesis induced by cytotoxic chemotherapeutic drugs by blocking substance P landing on receptors in the brains neurons. It has also been shown to increase the activity of the 5-HT3 receptor antagonists ondansetron and the corticosteroid dexamethasone, which are also used to prevent nausea and vomiting caused by chemotherapy.
Targets
| Neurokinin-1 receptor (Cell-free assay) | ||||
| 0.1 nM |
| In vitro (25°C) | DMSO | 96 mg/mL (179.63 mM) | |
| Water | Insoluble | ||
| Ethanol | 14 mg/mL (26.19 mM) | ||
| In vivo | 5% DMSO+corn oil | 12 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 18.71 mL | 93.56 mL | 187.13 mL |
| 0.5 mM | 3.74 mL | 18.71 mL | 37.43 mL |
| 1 mM | 1.87 mL | 9.36 mL | 18.71 mL |
| 5 mM | 0.37 mL | 1.87 mL | 3.74 mL |
*The above data is based on the productmolecular weight 534.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A10083 |
|---|---|
| Actions | Antagonist |
| CAS No. | 170729-80-3 |
| Formula | C23H21F7N4O3 |
| M. Wt | 534.4 |
| Purity | >98% |
| Synonyms | MK0869, MK-869, L-754030, Emend |
| SMILES | C[[email protected]](C1=CC(=CC(=C1)C(F)(F)F)C(F)(F)F)O[[email protected]@H]2[[email protected]@H](N(CCO2)CC3=NC(=O)NN3)C4=CC=C(C=C4)F |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
Datasheet
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Contact information
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