Dopamine Receptors

Cat. No.

A60043

CAS No.

87539-19-3

N-Methylspiroperidol

N-Methylspiroperidol is a potent D2 receptor antagonist that plays a critical role in neuropharmacological research. It can be utilized in PET (Positron Emission Tomography) imaging studies, allowing for the investigation of binding dynamics to the 5-HT2C receptor. This compound is particularly valuable for assessing neurotransmitter interactions, including the competitive effects of dopamine, thereby enhancing our understanding of neuropsychiatric disorders.

Cat. No.

A60044

CAS No.

69079-98-7

(Z)-Flupenthixol decanoate

(Z)-Flupenthixol decanoate is a potent antagonist of dopamine D1 and D2 receptors, functioning primarily to inhibit dopaminergic signaling. This compound exhibits significant antipsychotic activity, making it valuable in the study of psychiatric disorders and neuropharmacology. Research applications include investigations into the modulation of dopaminergic pathways and the evaluation of therapeutic strategies for schizophrenia and related conditions.

Cat. No.

A60045

CAS No.

87075-17-0

SCH-23390

Synonyms: R-(+)-SCH-23390

SCH-23390 is a potent antagonist of dopamine D1-like receptors, exhibiting Ki values of 0.2 nM for the D1 subtype and 0.3 nM for the D5 subtype. This compound plays a significant role in behavioral research by shortening the latency period for cocaine-induced lever pressing in rat models. Additionally, SCH-23390 has been shown to eliminate generalized seizures induced by chemical convulsants, making it valuable in the study of neurological disorders associated with the dopamine system.

Cat. No.

A60046

CAS No.

85966-89-8

Preclamol

Synonyms: (-)-3-PPP

Preclamol is a potent dopamine receptor agonist that stimulates both autoreceptors and postsynaptic receptors. It has been shown to inhibit locomotor activity in rodent models at low doses, making it a valuable tool for studying dopaminergic signaling and related behavioral effects. This compound is useful in research related to neuropharmacology and the exploration of dopamine-related disorders.

Cat. No.

A60047

CAS No.

81702-42-3

(R)-SKF 38393 hydrochloride

Synonyms: (±)-SKF-38393 hydrochloride; SKF-38393A hydrochloride

(R)-SKF 38393 hydrochloride is a potent and selective antagonist of the D1 dopamine receptor. This compound effectively inhibits G protein-coupled inwardly rectifying potassium (GIRK) channels, making it a valuable tool for exploring dopamine signaling pathways. It is commonly used in research applications focused on neuropharmacology and the modulation of dopaminergic systems.

Cat. No.

A60048

CAS No.

98323-83-2

Carmoxirole

Synonyms: EMD 45609

Carmoxirole is a selective peripheral dopamine D2 receptor agonist, demonstrating antihypertensive properties in vivo. This compound is valuable for research into the modulation of cardiovascular functions and the mechanisms underlying hypertension. Its targeted action on the D2 receptor makes it a useful tool for investigating dopaminergic signaling pathways.

Cat. No.

A60049

CAS No.

253446-15-0

(R)-SKF-81297 hydrobromide

(R)-SKF-81297 hydrobromide is the R-enantiomer of SKF-81297, acting primarily as a selective agonist for the dopamine D1 receptor. It demonstrates key biological activities related to the modulation of dopaminergic signaling pathways. This reagent is valuable in research applications focusing on neuropharmacology, including studies on dopamine-related disorders and the exploration of its effects on cognition and behavior.

Cat. No.

A60050

CAS No.

68556-59-2

Prosulpride

Synonyms: GRI 1665

Prosulpride is a neuroleptic compound that selectively antagonizes dopamine receptors, primarily targeting D2 and D3 subtypes. It exhibits significant antipsychotic properties, making it relevant for the treatment of various psychiatric disorders. Prosulpride is utilized in research to explore dopaminergic signaling pathways and to investigate its therapeutic potential in conditions such as schizophrenia and mood disorders.

Cat. No.

A60052

CAS No.

202645-74-7

JHW007 hydrochloride

JHW007 hydrochloride is a selective antagonist of dopamine receptors, primarily targeting the D2 subtype. It demonstrates notable activity in modulating neurotransmitter release and has been investigated for its potential effects in cocaine-related research. This compound is valuable for studies exploring addiction mechanisms and neuropharmacology.

Cat. No.

A60053

CAS No.

863680-46-0

(-)-GSK598809 ((1S,5R)-GSK598809)

Synonyms: (1S,5R)-GSK598809

(-)-GSK598809 is a selective antagonist of the dopamine D3 receptor (DRD3). This compound exhibits potent inhibition of DRD3 activity, making it a valuable tool for research into neuropsychiatric disorders and addiction. Its specificity for DRD3 allows for detailed investigations into dopamine-related signaling pathways and their implications for various therapeutic areas.

Cat. No.

A60054

CAS No.

25614-03-3

Bromocriptine

Synonyms: CB-154 free base

Bromocriptine is a potent agonist of the dopamine D2 and D3 receptors, exhibiting a high binding affinity with a pKi of 8.05 ± 0.2. This compound is primarily utilized in research to investigate dopaminergic signaling pathways and their implications in various neurological and psychiatric disorders. It is also employed in studies related to endocrine functions, particularly in conditions such as hyperprolactinemia and Parkinson's disease.

Cat. No.

A60055

CAS No.

127685-30-7

Seproxetine hydrochloride

Synonyms: S-Norfluoxetine hydrochloride; LY 215229 hydrochloride

Seproxetine hydrochloride is a dopamine receptor inhibitor known for its selective serotonin reuptake inhibitory activity. By specifically blocking the serotonin uptake transporter, it increases serotonin levels in the brain, while also exhibiting significant interactions with dopamine receptors. This compound is actively researched for its potential therapeutic applications in mood disorders and associated neurological conditions, showcasing enhanced biological activity and efficacy through its ability to form stable charge transfer complexes.

Cat. No.

A60056

CAS No.

111073-34-8

OPC-4392

OPC-4392 is an orally active presynaptic dopamine autoreceptor agonist and postsynaptic D2 receptor antagonist. This compound demonstrates significant antipsychotic activity by reversing Reserpine-induced dopamine depletion and inhibiting Apomorphine-induced stereotypic behaviors in murine models. OPC-4392 is a valuable reagent for research on antipsychotic therapies and the underlying mechanisms of dopamine modulation.

Cat. No.

A60057

CAS No.

20049-44-9

Nor-SCH-12679 maleate

Nor-SCH-12679 maleate is a dopamine receptor antagonist that plays a crucial role in research focused on dopaminergic signaling pathways. By inhibiting dopamine receptor activity, it can counteract the stimulatory effects of other compounds, such as peppermint oil, on locomotor activity in experimental models. This compound is valuable for studies investigating the modulation of behavior and neuropharmacological effects related to dopamine signaling.

Cat. No.

A60058

CAS No.

935776-74-2

JNJ-37822681

JNJ-37822681 is a fast-dissociating antagonist of the D2 dopamine receptor, primarily employed in the research of schizophrenia. This compound demonstrates high specificity for D2 receptors and effectively increases levels of extracellular serotonin, dopamine, and norepinephrine within the rat cerebral cortex. Additionally, JNJ-37822681 exhibits antidepressant-like effects in the mouse tail suspension test while achieving favorable brain distribution and minimizing prolactin release, making it a valuable tool for neuroscience research.

Cat. No.

A60060

CAS No.

1609583-15-4

(R)-PF-06256142

(R)-PF-06256142 is the R enantiomer of PF-06256142, selectively acting as an orthosteric agonist for the D1 dopamine receptor. This compound demonstrates significant potential in modulating receptor desensitization compared to dopamine and other catechol-containing agonists. Its properties make it a valuable tool for research into dopamine-related signaling pathways and receptor pharmacology.

Cat. No.

A60061

CAS No.

98185-20-7

Raclopride tartrate

Raclopride tartrate is a selective antagonist of the dopamine D2 and D3 receptors, exhibiting high binding affinity with Ki values of 1.8 nM and 3.5 nM, respectively. This compound demonstrates potential antipsychotic effects and is primarily utilized in research focused on the modulation of dopaminergic signaling. Its application extends to studying neuropsychiatric disorders and exploring therapeutic strategies for schizophrenia and related conditions.

Cat. No.

A60062

CAS No.

2376333-77-4

Dopamine D3 receptor ligand-4

Dopamine D3 receptor ligand-4 is a highly potent and selective ligand for the dopamine D3 receptor, exhibiting a Ki value of 0.5 nM. It demonstrates impressive selectivity for the D3 receptor over the D2 receptor, with a Ki of 7.43 nM. This compound is valuable for research applications focused on understanding dopamine-related pathways and potential therapeutic targets in neuropsychiatric disorders.

Cat. No.

A60063

CAS No.

245514-32-3

S 33138

S 33138 is a potent D3 receptor antagonist. This compound has demonstrated the ability to inhibit addictive behaviors in various animal models, as well as ameliorate cognitive deficits in rodent and primate models of schizophrenia and Parkinson's disease. S 33138 serves as a valuable tool for research applications focused on neurological disorders, advancing the understanding of pathophysiological mechanisms and potential therapeutic strategies.

Cat. No.

A60064

CAS No.

105277-43-8

PD 119819

PD 119819 is a selective dopamine autoreceptor agonist belonging to the benzopyran-4-one class. It modulates dopaminergic activity by inhibiting spontaneous locomotor activity and reducing brain dopamine synthesis. This compound is valuable for research into dopamine-related neurophysiology and the study of disorders influenced by dopamine receptor activity.

Cat. No.

A60065

CAS No.

95999-11-4

(-)-UH 232

(-)-UH 232 is a central dopamine receptor agonist with a primary action of modulating dopaminergic signaling. It has been shown to reduce the formation of 3,4-dihydroxyphenylalanine (DOPA) in striatal and limbic regions of the rat brain. This compound serves as a valuable tool for investigating neurological disorders, including Parkinson's disease and schizophrenia.

Cat. No.

A60066

CAS No.

189744-46-5

Ro 10-5824

Ro 10-5824 is a selective partial agonist of the dopamine D4 receptor (D4R), exhibiting a Ki value of 5.2 nM. This compound is noted for its ability to enhance novel object exploration in C57BL/6 mice, making it a valuable reagent for studies investigating cognitive behaviors and dopaminergic signaling. Ro 10-5824 is useful in research applications related to neuropharmacology and the understanding of psychiatric disorders.

Cat. No.

A60067

CAS No.

137550-79-9

RS-12254

RS-12254 is a dopamine receptor agonist that exerts hypotensive and diuretic effects through its regulation of blood pressure and electrolyte balance. This compound effectively lowers blood pressure and minimizes plasma norepinephrine levels, contributing to its diuretic and natriuretic properties. RS-12254 is valuable in research applications focused on cardiovascular regulation and sympathetic nerve activity modulation.

Cat. No.

A60068

CAS No.

172940-14-6

Berupipam hemifumarate

Berupipam hemifumarate is a selective dopamine D1 receptor antagonist, primarily utilized for investigating its role in psychotic disorders. It serves as a substrate for UDP-glucuronosyltransferase (UGT), exhibiting high affinity for UGT enzymes while displaying variability in glucuronidation rates across different species and genders. This compound is valuable for research focused on dopamine-mediated pathways and their implications in neuropsychiatric conditions.

Cat. No.

A60069

CAS No.

2379422-72-5

LY3154885

LY3154885 is an orally active positive allosteric modulator (PAM) targeting the dopamine D1 receptor. This compound enhances receptor activity, facilitating increased dopaminergic signaling. Its favorable drug-drug interaction profile makes it a valuable tool for research into dopamine-related pathways and potential therapeutic applications in neuropsychiatric disorders.