Dopamine Receptors

Cat. No.

A60013

CAS No.

124842-93-9

Y-20024 hydrochloride

Y-20024 hydrochloride is a selective D2 receptor antagonist known for its ability to cross the blood-brain barrier. It effectively inhibits Apomorphine-induced symptoms associated with attention deficit hyperactivity disorder (ADHD) in murine models and also mitigates Apomorphine-induced vomiting in canine subjects. This compound demonstrates prolactin-promoting activity and is valuable for research into neurological disorders such as ADHD and emesis.

Cat. No.

A60014

CAS No.

86636-93-3

Neflumozide

Synonyms: HRP 913

Neflumozide is a potent dopamine antagonist classified as a benzisoxazole derivative. It exhibits significant antipsychotic activity, making it a valuable tool for investigating psychosis and related conditions. This compound is useful in preclinical research aimed at understanding dopamine receptor modulation and its implications in psychiatric disorders.

Cat. No.

A60015

CAS No.

76352-13-1

Tropapride

Synonyms: MD 790501

Tropapride is a selective antagonist of the dopamine D2 receptor. It exhibits significant biological activity by modulating dopaminergic signaling, making it a valuable tool for investigating neurological disorders. This compound is commonly utilized in research focused on conditions such as schizophrenia, Parkinson's disease, and other related neurological dysfunctions.

Cat. No.

A60016

CAS No.

632-47-3

Bulbocapnine hydrochloride

Bulbocapnine hydrochloride is a potent dopamine receptor inhibitor that plays a significant role in modulating dopaminergic activity. This aporphine alkaloid is known to inhibit dopamine synthesis and exhibits neuroleptic-like properties, alongside anticonvulsant and antinociceptive effects. Its pharmacological profile makes it a valuable tool in research related to neurological disorders and the exploration of dopamine-related pathways.

Cat. No.

A60017

CAS No.

130465-45-1

A68930

A68930 is a selective agonist of the dopamine D1 receptor, which plays a crucial role in various neurological processes. Its primary biological activity includes the modulation of neural pathways related to dopamine signaling. A68930 is utilized in research investigating bronchiectasis and related pulmonary conditions, aiming to elucidate the role of dopamine in respiratory physiology and potential therapeutic strategies.

Cat. No.

A60018

CAS No.

192384-87-5

BP 897

BP 897 is a potent partial agonist of the dopamine D3 receptor and exhibits weak antagonistic activity at the D2 receptor. With a high affinity for the D3 receptor (Ki=0.92 nM) and significantly lower affinity for the D2 receptor (Ki=61 nM), BP 897 is a valuable tool for studying dopaminergic signaling. This compound is primarily used in research related to neuropsychiatric disorders and the role of dopamine receptors in therapeutic contexts.

Cat. No.

A60022

CAS No.

1135278-61-3

3'-Fluorobenzylspiperone maleate

3'-Fluorobenzylspiperone maleate is a selective ligand for dopamine D2 receptors, demonstrating significant potential in the modulation of dopaminergic activity. This compound has been shown to exhibit improved efficacy in alleviating behavioral disorders compared to placebo, making it a valuable tool for research into neuropsychiatric conditions and the pharmacological study of dopamine pathways. Its targeted action underscores its relevance in the investigation of dopamine-mediated therapeutic interventions.

Cat. No.

A60023

CAS No.

7416-34-4

Molindone

Synonyms: (±)-Molindone; SPN-810M

Molindone is a potent antagonist of dopamine D2 and D5 receptors, classified as an indole derivative. This compound exhibits significant biological activity in modulating dopaminergic neurotransmission and is primarily used in the research of schizophrenia and severe mental illnesses. Its mechanism of action makes it a valuable tool for studying dopaminergic pathways and their implications in psychiatric disorders.

Cat. No.

A60024

CAS No.

138-56-7

Trimethobenzamide

Synonyms: Ro 2-9578 free base

Trimethobenzamide is a D2 receptor blocker that serves as an effective antiemetic. It is primarily used to prevent nausea and vomiting, making it valuable in various clinical settings. This compound can be utilized in research applications focused on gastrointestinal motility and central nervous system interactions.

Cat. No.

A60026

CAS No.

911378-38-6

RBI-257 maleate

RBI-257 maleate is a potent antagonist of the dopamine D4 receptor, exhibiting a Ki value of 0.3 nM. This compound has demonstrated significant biological activity in modulating dopaminergic signaling and is valuable for research applications related to neuropharmacology and psychiatric disorders. Its selectivity for the D4 receptor makes it a suitable tool for investigating the role of dopamine in various behavioral and neurological models.

Cat. No.

A60027

CAS No.

866021-03-6

L-745870 trihydrochloride

L-745870 trihydrochloride is a selective antagonist of the dopamine D4 receptor, characterized by a Ki value of 0.43 nM. This compound demonstrates reduced affinity for D2 and D3 receptors, with Ki values of 960 nM and 2300 nM, respectively. Additionally, L-745870 shows moderate interactions with 5-HT2 receptors, sigma sites, and α-adrenoceptors. It is primarily utilized in research focused on neuropharmacology and the modulation of dopaminergic pathways.

Cat. No.

A60028

CAS No.

68593-96-4

5-OH-DPAT

Synonyms: 5-Hydroxy-DPAT

5-OH-DPAT (5-Hydroxy-DPAT) is a potent and selective agonist of the dopamine D2 receptor, with minimal activity at 5-HT receptors. This compound is known to enhance male rat sexual behavior, providing insights into the role of dopamine in sexual function. As a valuable tool in neuropharmacology research, 5-OH-DPAT can be utilized to study dopamine receptor signaling and its implications in various behavioral models.

Cat. No.

A60029

CAS No.

20012-08-2

Trepipam

Synonyms: Trimopam; SCH-12679

Trepipam is a D1-dopamine receptor antagonist, primarily utilized for its neuroprotective properties. It has demonstrated efficacy in reducing self-injurious behavior in 6-OHDA-lesioned rats, making it a valuable tool in behavioral neuroscience studies. Trepipam has potential applications in researching conditions such as epilepsy and anxiety disorders, facilitating insights into dopaminergic signaling pathways.

Cat. No.

A60030

CAS No.

170856-57-2

U 101958

U 101958 is a potent full agonist of the dopamine D4 receptor, exhibiting a pEC50 of 8.7 in HEK293 cells expressing the D4 receptor. This compound demonstrates significant biological activity and is valuable for research in neuropharmacology, particularly in studies examining the role of dopamine signaling in psychiatric disorders. Its selectivity for the D4 receptor can aid in the exploration of D4-mediated effects in various biological systems.

Cat. No.

A60031

CAS No.

81264-57-5

(-)-MDO-NPA

(-)-MDO-NPA is a dual-target ligand for dopamine receptors D1R and D2R, functioning as an N-propylnorapomorphine analog. It demonstrates β-arrestin EC50 values of 1949 nM for D1R and 520 nM for D2R, and cAMP EC50 values of 717.5 nM for D1R and 7.7 nM for D2R. This compound is particularly valuable for studying dopamine-related disorders, including Parkinson's disease, and contributes to understanding receptor signaling pathways in pharmacological research.

Cat. No.

A60032

CAS No.

51012-32-9

Tiapride

Tiapride is a selective antagonist of the D2 and D3 dopamine receptors, exhibiting IC50 values of 110-320 nM and 180 nM, respectively. This compound demonstrates anti-dyskinetic and anxiolytic properties, making it valuable in neurological research. Tiapride is classified as a neuroleptic agent and is utilized in studies related to movement disorders and anxiety-related conditions.

Cat. No.

A60033

CAS No.

139689-10-4

(S)-SKF-77434

Synonyms: (S)-APB

(S)-SKF-77434 is a selective enantiomer targeting the dopamine D1 receptor, exhibiting an IC50 value of 2800 nM. This compound is utilized in research focused on neuropsychiatric disorders, providing insights into dopamine receptor modulation. Its affinity for the D1 receptor makes it a valuable tool for exploring the mechanisms underlying cognitive and behavioral functions.

Cat. No.

A60034

CAS No.

3033883-17-6

D3R/MOR antagonist 2

D3R/MOR antagonist 2 targets the dopamine D3 receptor (D3R) and the mu-opioid receptor (MOR) as a dual antagonist. With affinities of Ki 361 nM for D3R and 85.2 nM for MOR, this compound exhibits potential analgesic effects through MOR partial agonism while simultaneously mitigating opioid misuse liability via D3R antagonism. It serves as a valuable tool for research in pain management and addiction pharmacology.

Cat. No.

A60036

CAS No.

873445-60-4

SV 156

SV 156 is a highly selective antagonist of the D2 dopamine receptor, exhibiting a Ki value of 2.5 nM for human D2 receptors. With approximately 40-fold selectivity for the D2 receptor over the D3 subtype, SV 156 is primarily utilized in research related to L-DOPA-associated abnormal involuntary movements (AIMs). This compound serves as a valuable tool for investigating the mechanisms underlying dopaminergic signaling and movement disorders.

Cat. No.

A60037

CAS No.

1301178-83-5

(±)-BAK2-66

(±)-BAK2-66 is a potent dopamine D3 receptor antagonist, exhibiting Ki values of 1 nM for the D3 receptor and 960 nM for the D2 receptor. This compound is valuable for research applications focused on modulating dopaminergic signaling and exploring mechanisms underlying addiction in animal models. Its selectivity makes it an important tool for studying the role of the D3 receptor in various neurological conditions.

Cat. No.

A60038

CAS No.

80125-14-0

(S)-Remoxipride

Synonyms: (-)-Remoxipride

(S)-Remoxipride is a selective antagonist of the dopamine D2 receptor, exhibiting an IC50 value of 1.57 μM. This compound is primarily utilized in research pertaining to psychotic disorders, offering insights into dopaminergic signaling and its implications in various neuropsychiatric conditions. Its specificity for the D2 receptor makes it a valuable tool for studying the effects of dopamine modulation in both in vitro and in vivo settings.

Cat. No.

A60039

CAS No.

2983777-67-7

D1R antagonist 1

D1R Antagonist 1 is a selective antagonist of the dopamine D1 receptor (D1R), functioning through the inhibition of G-protein-mediated and β-arrestin-mediated signaling pathways. This compound is valuable for research focused on dopamine-related neuropharmacology, allowing for the investigation of D1R-linked physiological processes and potential therapeutic applications in dopamine-related disorders.

Cat. No.

A60040

CAS No.

474432-65-0

FAUC 346

FAUC 346 is a highly selective partial agonist of the dopamine D3 receptor, exhibiting an EC50 of 1.5 nM. This compound demonstrates significant biological activity in modulating dopaminergic signaling, making it a valuable tool for research focused on neuropharmacology and psychiatric disorders. FAUC 346 can be utilized to explore the therapeutic potential of D3 receptor modulation in various neurological conditions.

Cat. No.

A60041

CAS No.

1639208-51-7

Valbenazine dihydrochloride

Synonyms: NBI-98854 dihydrochloride

Valbenazine dihydrochloride is a selective inhibitor of the vesicular monoamine transporter 2 (VMAT2) and primarily targets dopamine receptors. It is utilized in the treatment of tardive dyskinesia, offering therapeutic benefits for alleviating movement disorder symptoms linked to chronic dopamine receptor antagonism. Extensive preclinical studies support its efficacy, particularly in relation to the genetic factors contributing to tardive dyskinesia.

Cat. No.

A60042

CAS No.

452917-21-4

AVE-5997

AVE-5997 is a selective D3 dopamine receptor antagonist. It effectively reduces hyperactivity induced by MK-801, making it a valuable tool for studying dopaminergic dysregulation. This compound is particularly relevant in the research of schizophrenia and related neuropsychiatric disorders.