Acyltransferases

Cat. No.

A69199

CAS No.

828934-40-3

(S)-(+)-Etomoxir

(S)-(+)-Etomoxir is the S enantiomer of Etomoxir, an irreversible inhibitor of carnitine palmitoyltransferase 1a (CPT-1a). This compound effectively inhibits fatty acid oxidation (FAO) by targeting CPT-1a, thereby reducing palmitate β-oxidation in human, rat, and guinea pig tissues. (S)-(+)-Etomoxir is widely used in research related to metabolism, obesity, and diabetes to explore the role of fatty acid metabolism in various physiological and pathological conditions.

Cat. No.

A69201

CAS No.

1808258-99-2

BMS-986172

BMS-986172 is a selective inhibitor of Monoacylglycerol acyltransferase 2 (MGAT2), demonstrating an IC50 of 4.6 nM for human MGAT2 and 20 nM for mouse MGAT2. This orally active compound has been shown to reduce food intake and body weight, making it a valuable tool for researching metabolic disorders, particularly obesity. Its efficacy in modulating MGAT2 activity supports its potential in addressing various metabolic diseases.

Cat. No.

A69204

CAS No.

1048244-34-3

ANAT inhibitor-2

ANAT inhibitor-2 is a selective inhibitor of the enzyme arylacetamide deacetylase (ANAT), which plays a role in the metabolism of various substrates. With an IC50 value of 20 μM, this compound demonstrates significant inhibitory activity, making it an important tool for studying canavan disease and its underlying biochemical pathways. Research applications include investigations into metabolic disorders and the development of therapeutic strategies for genetic conditions associated with ANAT dysfunction.

Cat. No.

A69205

CAS No.

3055162-52-9

AANAT-IN-1

AANAT-IN-1 is a potent inhibitor of aralkylamine N-acetyltransferase (AANAT), demonstrating an IC50 value of 10μM. AANAT plays a critical role in the synthesis of melatonin, a hormone implicated in various disorders, including seasonal affective disorder (SAD), characterized by dysregulated melatonin levels. This compound serves as a valuable research tool for studying the mechanisms of melatonin synthesis and its impact on seasonal mood fluctuations.

Cat. No.

A69206

CAS No.

1060438-30-3

H2-003

H2-003 is a selective inhibitor of human diacylglycerol O-acyltransferase 2 (DGAT2), targeting triglyceride biosynthesis. This compound demonstrates effectiveness in inhibiting lipid droplet formation in 3T3-L1 adipocytes, making it a valuable tool for studying DGAT2 function. H2-003 is applicable in research focusing on DGAT2 and metabolic disorders associated with triglyceride accumulation.

Cat. No.

A69207

CAS No.

119-47-1

GERI-BP002-A

GERI-BP002-A is an acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor derived from Aspergillus fumigatus F93. This compound is primarily utilized in cancer research, where it plays a crucial role in studying lipid metabolism and its impact on tumor progression. By inhibiting ACAT, GERI-BP002-A contributes to the alteration of cholesterol esters, facilitating investigations into lipid-related pathways in various cancer models.

Cat. No.

A69208

CAS No.

156967-65-6

Terpendole C

Terpendole C is a potent acyl-CoA: cholesterol acyltransferase (ACAT) inhibitor derived from Albophoma yamanashiensis. This compound exhibits significant biological activity in modulating lipid metabolism by inhibiting the conversion of cholesterol to cholesteryl esters. Terpendole C is widely utilized in research focusing on cholesterol-related disorders and lipid metabolism studies.

Cat. No.

A69209

CAS No.

81840-57-5

Yakuchinone B

Yakuchinone B is an Acyl-CoA: cholesterol O-acyltransferase (ACAT) inhibitor that exhibits hypocholesterolemic activity. Isolated from the seeds of Zingiberaceae, it specifically inhibits rat hepatic ACAT with an IC50 value of 20.6 μM. This compound holds potential for research applications related to hypercholesterolemia and atherosclerosis, contributing to the understanding of cholesterol metabolism and cardiovascular health.

Cat. No.

A69211

CAS No.

128831-46-9

TMP-153

TMP-153 is a potent inhibitor of Acyl-CoA:cholesterol acyltransferase (ACAT) with an IC50 value ranging from 5-10 nM for hepatic and intestinal ACAT, demonstrated in preclinical studies. This compound effectively reduces cholesterol levels and is primarily utilized in research related to atherosclerosis and lipid metabolism. TMP-153's mechanism of action makes it a valuable tool for studying cholesterol-related disorders and their potential therapeutic interventions.

Cat. No.

A69212

CAS No.

2267352-04-3

S-309309

S-309309 is a selective inhibitor of MGAT2, an enzyme involved in glycan biosynthesis. This compound demonstrates oral bioactivity and has potential applications in metabolism-related research, particularly in the study of lipid metabolism and its implications in metabolic disorders. S-309309 may serve as a valuable tool for investigating the role of MGAT2 in cellular pathways and metabolic regulation.

Cat. No.

A69213

CAS No.

6575-24-2

2,6-Dichlorophenylacetic acid

2,6-Dichlorophenylacetic acid acts as an inhibitor of isopenicillin N synthase (IPNS) and acyl-CoA: 6-APA acyltransferase. This compound exhibits notable cytostatic activity against tumor cells, making it a valuable tool in cancer research. Its role in modulating bacterial cell wall biosynthesis positions it as a relevant agent for studying antibiotic mechanisms and drug development.

Cat. No.

A69218

CAS No.

331751-78-1

ANAT inhibitor-1

ANAT inhibitor-1 is a selective inhibitor of human aspartate N-acetyltransferase (ANAT), specifically developed for research into canavan disease. By inhibiting ANAT, this compound plays a crucial role in studying the biochemical pathways disrupted in this disorder. Its application extends to elucidating the mechanisms underlying neurodegenerative conditions and developing potential therapeutic strategies.

Cat. No.

A69219

CAS No.

1402702-76-4

ST1060

ST1060 is a selective ceramide synthase 2 (CerS2) inhibitor. It effectively reduces the levels of long-chain dihydroceramide (dhCer) with IC50 values of 63.6 μM and 61.3 μM for C24:0 and C24:1, respectively. This compound is valuable for research applications involving lipid metabolism, cellular stress responses, and potential therapeutic strategies targeting sphingolipid pathways.

Cat. No.

A69220

CAS No.

179054-51-4

FR-182980

FR-182980 is a potent orally active inhibitor of acyl-CoA:cholesterol acyltransferase 1 (ACAT1), with an IC50 of 30 nM. This compound exhibits notable hypocholesterolemic activity, making it a valuable tool for the study of atherosclerosis and related lipid metabolism disorders. Researchers can utilize FR-182980 to investigate the role of ACAT1 in cholesterol homeostasis and its potential as a therapeutic target in cardiovascular diseases.

Cat. No.

A69222

CAS No.

55303-92-9

Penicillide

Synonyms: Vermixocin A

Penicillide, an acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor, is derived from the fungus Talaromyces derxii cultivated on rice. This compound exhibits significant inhibitory activity against ACAT, making it valuable for studies related to cholesterol metabolism and lipid disorders. Researchers can utilize Penicillide to explore its potential applications in understanding the regulation of cholesterol homeostasis and its implications in cardiovascular diseases.

Cat. No.

A69224

CAS No.

185539-34-8

SM-32504

SM-32504 is a potent inhibitor of acyl-CoA:cholesterol acyltransferase (ACAT), exhibiting significant capability to lower serum cholesterol levels in mouse models subjected to high-fat and high-cholesterol diets. This compound serves as a valuable tool for studying hypercholesterolemia and atherosclerosis, providing insights into lipid metabolism and associated cardiovascular diseases.

Cat. No.

A69228

CAS No.

124884-99-7

YM-17E hydrochloride

YM-17E hydrochloride is a potent inhibitor of acyl CoA:cholesterol acyltransferase (ACAT), demonstrating an IC50 of 44 nM. This compound exhibits significant hypocholesterolemic effects, making it valuable for research in cholesterol metabolism and cardiovascular disease. Its application in studies on lipid regulation may advance understanding of lipid-related disorders.

Cat. No.

A69232

CAS No.

141993-70-6

Eldacimibe

Synonyms: WAY-ACA 147

Eldacimibe is an inhibitor of acyl-CoA:cholesterol acyltransferase 2 (ACAT2), which plays a crucial role in cholesterol metabolism. This compound effectively reduces plasma cholesterol levels by inhibiting cholesterol absorption and preventing the transformation of macrophages into foam cells. Eldacimibe is applicable in research focused on cardiovascular diseases such as atherosclerosis, as well as endocrine and metabolic disorders, particularly hypercholesterolemia.

Cat. No.

A69233

CAS No.

96224-26-9

CL 277082

CL 277082 is a potent and selective inhibitor of acyl CoA:cholesterol acyltransferase (ACAT). It exhibits robust inhibitory activity with IC50 values of 0.14 μM in intestinal mucosal microsomes, 0.74 μM in liver microsomes, and 1.18 μM in rat adrenal microsomes. This compound effectively inhibits the ACAT-mediated cholesterol esterification process, making it a valuable tool for research into cholesterol absorption and metabolism.

Cat. No.

A69234

CAS No.

1710630-11-7

MGAT2-IN-2

MGAT2-IN-2 is a highly selective inhibitor of acyl CoA:monoacylglycerol acyltransferase 2 (MGAT2), demonstrating an IC50 of 3.4 nM. This compound is instrumental in studying lipid metabolism and associated metabolic disorders, making it valuable for research in obesity and diabetes. Its potent inhibitory activity offers potential avenues for therapeutic development targeting MGAT2.

Cat. No.

A69239

CAS No.

1841424-92-7

MGAT2-IN-4

MGAT2-IN-4 is a selective inhibitor of monoacylglycerol transferase 2 (MGAT2), demonstrating metabolic stability in the liver. This compound is instrumental for investigating the roles of MGAT2 in metabolic disorders such as obesity, diabetes, and non-alcoholic steatohepatitis (NASH). Researchers can utilize MGAT2-IN-4 to explore therapeutic strategies targeting these conditions.

Cat. No.

A69243

CAS No.

5429-85-6

Oleyl anilide

Synonyms: Oleic acid anilide; OAA

Oleyl anilide is an inhibitor of acyl-coenzyme A:cholesterol acyltransferase (ACAT), with an IC50 value of 26 µM. This compound primarily disrupts cholesterol esterification, making it a valuable tool for studying lipid metabolism and associated disorders. Research applications include investigations into cholesterol homeostasis and the development of potential therapeutic strategies for conditions linked to aberrant lipid accumulation.

Cat. No.

A69245

CAS No.

129095-76-7

Ilexoside XLVIII

Ilexoside XLVIII is identified as an acyl CoA cholesteryl acyl transferase (ACAT) inhibitor. This compound, a triterpene saponin sourced from the aqueous extract of Ilex kudincha leaves, demonstrates significant biological activity related to lipid metabolism regulation. It is primarily used in research applications focused on cholesterol homeostasis and related metabolic disorders.

Cat. No.

A69247

CAS No.

130804-35-2

Lecimibide

Synonyms: DuP 128

Lecimibide is a potent and selective inhibitor of acyl-CoA:cholesterol acyltransferase (ACAT), which plays a crucial role in cholesterol metabolism. This compound demonstrates significant antihyperlipidemic activity, making it valuable for research into lipid disorders and cardiovascular diseases. Lecimibide can be utilized in studies focusing on the modulation of cholesterol levels and the exploration of therapeutic strategies for hyperlipidemia.

Cat. No.

A69248

CAS No.

162490-89-3

F-1394

F-1394 is an orally active acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor, designed to impede dietary cholesterol absorption. This compound exhibits significant biological activity in reducing cholesterol levels and is widely applied in cardiovascular disease research. F-1394 provides valuable insights into cholesterol metabolism and the potential therapeutic strategies for related disorders.