Drug Metabolite

Cat. No.

A70837

CAS No.

1283861-33-5

3'-Hydroxy simvastatin

3'-Hydroxy simvastatin is a key metabolite of simvastatin, which serves as a competitive inhibitor of HMG-CoA reductase (HMGCR) with a Ki of 0.2 nM. This compound retains significant biological activity relevant to cholesterol biosynthesis regulation and lipid metabolism. It is primarily used in research focusing on cardiovascular diseases and the pharmacodynamics of statin therapy.

Cat. No.

A70859

CAS No.

183320-29-8

OSI-413 free base

Synonyms: CP 373413

OSI-413 free base is a significant metabolite of Erlotinib, a potent EGFR tyrosine kinase inhibitor with an IC50 of 2 nM for human EGFR. This compound is instrumental in studying Erlotinib's metabolic pathways and its pharmacological effects. OSI-413 may provide valuable insights into alternative mechanisms of action and resistance, making it a relevant tool for cancer research, particularly in contexts involving EGFR-targeted therapies.

Cat. No.

A70900

CAS No.

205754-32-1

(Rac)-8-Hydroxy-efavirenz

(Rac)-8-Hydroxy-efavirenz is a metabolite of Efavirenz, functioning primarily as a non-nucleoside inhibitor of HIV-1 reverse transcriptase. This compound exhibits significant biological activity in the context of HIV research, contributing to the understanding of drug metabolism and efficacy. It is relevant for studies focusing on the pharmacokinetics and potential resistance mechanisms associated with antiretroviral therapy.

Cat. No.

A70908

CAS No.

1015073-44-5

PSI-7410

PSI-7410 is the active metabolite of PSI-7851, a known inhibitor of Hepatitis C virus (HCV) nonstructural protein 5B (NS5B). PSI-7410 exhibits antiviral activity, making it an important compound for research related to HCV replication and potential therapeutic interventions. Its role as a metabolite provides insight into the pharmacokinetics and efficacy of PSI-7851 in HCV treatment studies.

Cat. No.

A70911

CAS No.

135308-74-6

N,O-Didesmethylvenlafaxine

Synonyms: NODVFX

N,O-Didesmethylvenlafaxine is a key metabolite of venlafaxine, functioning primarily as a serotonin (5-HT) and norepinephrine (NE) reuptake inhibitor. This compound exhibits significant biological activity in modulating serotonin and norepinephrine levels, making it relevant in studies on mood disorders and antidepressant pharmacology. It serves as an important analytical standard for understanding the pharmacokinetics and pharmacodynamics of venlafaxine and its effects in clinical research applications.

Cat. No.

A70931

CAS No.

151602-49-2

5-O-Desmethyl omeprazole

5-O-Desmethyl omeprazole is a metabolic product of the proton pump inhibitor Omeprazole, generated through the action of cytochrome P450 enzymes. This compound is crucial for studying drug metabolism and pharmacokinetics, particularly in understanding the biotransformation of Omeprazole. Its analysis can provide insight into drug interactions and the therapeutic efficacy of proton pump inhibitors in clinical research.

Cat. No.

A70935

CAS No.

313989-46-7

Desmethyl-K777

Desmethyl-K777 is a key metabolite of K777, acting primarily through the inhibition of protein arginine methyltransferases (PRMTs). This compound exhibits potential in modulating cellular processes involved in cancer and other diseases characterized by altered methylation patterns. It is valuable for research applications focusing on epigenetic regulation and the therapeutic exploration of PRMTs in various biological contexts.

Cat. No.

A70952

CAS No.

949095-98-1

Duloxetine metabolite Para-Naphthol Duloxetine

Synonyms: Para-Naphthol duloxetine

Para-Naphthol Duloxetine is a drug metabolite derived from Duloxetine, a serotonin-norepinephrine reuptake inhibitor (SNRI). This compound is important for understanding the pharmacokinetics and pharmacodynamics of Duloxetine, as it may contribute to the drug's efficacy and side effect profile. Research applications include studies on metabolic pathways, drug interactions, and the therapeutic effects of SNRIs in various clinical contexts.

Cat. No.

A70999

CAS No.

1809100-36-4

(Rac)-5-Oxo-pitavastatin

(Rac)-5-Oxo-pitavastatin is a metabolite of Pitavastatin, a potent HMG-CoA reductase inhibitor. This compound serves as a valuable tool for studying the pharmacokinetics and pharmacodynamics of Pitavastatin. Its role in cholesterol biosynthesis modulation makes it relevant for research in cardiovascular diseases and lipid metabolism.

Cat. No.

A71019

CAS No.

1485081-26-2

N-De-2,4-difluorobenzyl dolutegravir

N-De-2,4-difluorobenzyl dolutegravir is a metabolite of Dolutegravir, an HIV integrase inhibitor that exhibits potent antiviral activity. This compound can be utilized in research applications focused on studying the metabolic pathways of Dolutegravir and its pharmacokinetics in HIV treatment. Understanding the properties of this metabolite may contribute to the development of improved therapeutic strategies and insights into drug resistance mechanisms.

Cat. No.

A73606

CAS No.

15087-06-6

Estriol 3-glucuronide sodium salt

Synonyms: Estriol 3-β-D-Glucuronide sodium salt

Estriol 3-glucuronide sodium salt is a conjugated metabolite of estriol, primarily recognized for its role in glucuronidation. It serves as a competitive inhibitor of the hydrolysis of 4-methylumbelliferyl-β-D-glucuronide (4Mu-GlcU) and acts as a substrate for hydrolysis by Klotho-human IgG1 Fc protein (KLFc). This compound is valuable for studies investigating steroid metabolism, enzymatic activity, and the physiological roles of estriol metabolites in various biological processes.

Cat. No.

A74723

CAS No.

140-38-5

4-Chlorophenylurea

Synonyms: NSC-12971

4-Chlorophenylurea is a metabolite of diflubenzuron that serves as a candidate for developing factor Xa inhibitors. It exhibits significant biological activity relevant to enzymatic inhibition pathways. This compound is primarily utilized in chemical research focused on anticoagulant drug development and associated pharmacological studies.