Drug Metabolite

Cat. No.

A70374

CAS No.

176655-55-3

Ritonavir metabolite

Synonyms: Desthiazolylmethyloxycarbonyl Ritonavir

Ritonavir metabolite is a key drug metabolite of Ritonavir, a well-known HIV protease inhibitor. This compound is primarily utilized in pharmacokinetic studies to understand the metabolism and pharmacological effects of Ritonavir. Its biological activity contributes to the assessment of drug interactions and therapeutic efficacy in HIV treatment research.

Cat. No.

A70383

CAS No.

15883-20-2

N-Desbutyl Bupivacaine

Synonyms: Desbutylbupivacaine

N-Desbutyl Bupivacaine is a significant metabolite of Bupivacaine, functioning primarily as an NMDA receptor inhibitor and SCN5A antagonist. This compound plays a crucial role in the pharmacokinetics of Bupivacaine, contributing to its analgesic properties. It is utilized in research focused on pain management and the study of local anesthesia mechanisms, helping to better understand drug metabolism and efficacy.

Cat. No.

A70473

CAS No.

1126899-61-3

PHA-782584

PHA-782584 is a metabolite of sunitinib, which serves as a multitargeted tyrosine kinase inhibitor. This compound exhibits significant antitumor activity, making it relevant for cancer research applications. Investigating PHA-782584 can enhance the understanding of sunitinib's therapeutic effects and metabolic pathways.

Cat. No.

A70479

CAS No.

153365-82-3

Threo-dihydrobupropion

Threo-dihydrobupropion is a significant metabolite of bupropion, produced through oxidative and reductive processes. It exhibits pharmacological activity that may contribute to the therapeutic effects of bupropion, which functions as a dual inhibitor of dopamine and norepinephrine uptake, as well as a nicotine receptor antagonist. This compound is valuable for research into depression treatment and smoking cessation strategies.

Cat. No.

A70480

CAS No.

404844-03-7

N-Desmethyl imatinib mesylate

Synonyms: Norimatinib mesylate; Imatinib metabolite N-Desmethyl imatinib mesylate; CGP 74588 mesylate

N-Desmethyl imatinib mesylate is an active metabolite of imatinib, primarily functioning as a selective inhibitor of the c-Abl kinase. It effectively binds to the c-Abl catalytic domain, obstructing substrate phosphorylation and inhibiting the c-Abl-mediated activation of α-synuclein, as well as associated inflammatory signaling pathways. This compound promotes apoptosis in K562 human leukemia cells and demonstrates enhanced plasma concentrations in gastrointestinal stromal tumor contexts, especially following mild SARS-CoV-2 infection. N-Desmethyl imatinib mesylate is valuable for research into Parkinson's disease, gastrointestinal stromal tumors, and chronic myeloid leukemia.

Cat. No.

A70490

CAS No.

2803552-55-6

AN7602

AN7602 is a metabolite of the anti-inflammatory agent Crisaborole, a selective phosphodiesterase 4 (PDE4) inhibitor. This compound is utilized in the investigation of mild to moderate atopic dermatitis (AD), providing insights into the anti-inflammatory mechanisms and therapeutic potential in dermatological research.

Cat. No.

A70494

CAS No.

819058-88-3

A-849529

A-849529 is an acid metabolite of ABT-869, a potent, orally active multi-target inhibitor of the vascular endothelial growth factor receptor (VEGFR) and platelet-derived growth factor receptor (PDGFR) families. This compound retains significant biological activity, making it valuable for research focused on angiogenesis and tumor growth inhibition. A-849529 is suitable for studies investigating the mechanisms of action of VEGFR and PDGFR inhibitors in various cancer models.

Cat. No.

A70542

CAS No.

81093-43-8

3α-Hydroxy pravastatin sodium

3α-Hydroxy pravastatin sodium is the principal metabolite of pravastatin, functioning as a competitive inhibitor of HMG-CoA reductase. This compound is implicated in the regulation of cholesterol biosynthesis and plays a crucial role in lipid metabolism studies. Its biological activity makes it valuable for research applications focusing on cardiovascular diseases and the pharmacokinetics of statin therapies.

Cat. No.

A70546

CAS No.

1351692-92-6

Febuxostat acyl glucuronide

Synonyms: Febuxostat acyl-β-D-glucuronide

Febuxostat acyl glucuronide is a metabolite of Febuxostat, a selective and non-purine inhibitor of xanthine oxidase (XO). This compound plays a critical role in studying the pharmacokinetics and pharmacodynamics of Febuxostat, as it can provide insights into its metabolic pathways and therapeutic efficacy. Research applications include investigations into gout treatment and the evaluation of the drug's metabolic stability and safety profile.

Cat. No.

A70547

CAS No.

84484-78-6

Didesmethylsibutramine hydrochloride

Synonyms: BTS 54-505

Didesmethylsibutramine hydrochloride is the primary amine metabolite of sibutramine, primarily acting as a reuptake inhibitor. This compound exhibits significant biological activity by inhibiting NMDA-evoked activity, which is important for neuropharmacology research. Additionally, didesmethylsibutramine hydrochloride is known to induce thermogenesis, making it valuable for studies related to weight management and energy metabolism.

Cat. No.

A70591

CAS No.

1394861-12-1

Desmethylene paroxetine hydrochloride

Desmethylene paroxetine hydrochloride is a significant urinary metabolite of paroxetine, which functions primarily as a selective serotonin reuptake inhibitor (SSRI). This compound serves as a valuable reference standard in pharmacokinetic studies and drug metabolism research. Its role in understanding the pharmacological effects and safety profiles of paroxetine can facilitate the development of therapeutic strategies for mood disorders.

Cat. No.

A70613

CAS No.

142761-12-4

(S)-(+)-O-Desmethyl Venlafaxine

(S)-(+)-O-Desmethyl Venlafaxine is the S-enantiomer of O-Desmethyl Venlafaxine, an active metabolite of the antidepressant Venlafaxine, classified as a serotonin-norepinephrine reuptake inhibitor (SNRI). This compound is utilized in pharmacological research to investigate its role in regulating serotonin and norepinephrine levels, which may have implications for treating mood disorders. Studies on this metabolite contribute to a deeper understanding of SNRIs' mechanisms and their potential therapeutic applications.

Cat. No.

A70615

CAS No.

120398-66-5

Perindopril acyl-β-D-glucuronide

Perindopril acyl-β-D-glucuronide is a metabolite of the ACE inhibitor Perindopril. This compound plays a crucial role in the metabolic pathway of Perindopril, influencing its pharmacokinetics and pharmacodynamics. It is essential for research applications related to cardiovascular diseases, allowing scientists to study the effects of ACE inhibition and the therapeutic potential of Perindopril in diverse biological contexts.

Cat. No.

A70623

CAS No.

1015167-40-4

Dabigatran acyl-β-D-glucuronide

Dabigatran acyl-β-D-glucuronide is an active metabolite of the direct thrombin inhibitor Dabigatran. This compound enhances activated partial thromboplastin time (aPTT) in isolated human platelet-poor plasma, reflecting its anticoagulant properties. It is valuable for studying the pharmacokinetics and pharmacodynamics of anticoagulants in various research applications.

Cat. No.

A70649

CAS No.

163217-70-7

4-Hydroxy Atorvastatin lactone

Synonyms: P-Hydroxyatorvastatin lactone; 4-ATL

4-Hydroxy Atorvastatin lactone is a metabolite of Atorvastatin, an orally active inhibitor of HMG-CoA reductase. This compound exhibits significant activity in lipid-lowering, making it valuable for studies related to cholesterol management and cardiovascular health. It is utilized in biochemical and pharmacological research to investigate the effects of statins on lipid metabolism and overall cardiovascular risk.

Cat. No.

A70680

CAS No.

463962-56-3

Simvastatin Acyl-β-D-glucuronide

Simvastatin Acyl-β-D-glucuronide is a primary metabolite of Simvastatin, which functions as a competitive inhibitor of HMG-CoA reductase with a Ki of 0.2 nM. This compound plays a significant role in the pharmacokinetics of Simvastatin and is utilized in research applications focused on lipid metabolism and cholesterol regulation. Its analysis can provide insights into the metabolic pathways and efficacy of statin therapeutics.

Cat. No.

A70691

CAS No.

171489-03-5

Desmethylene tadalafil

Desmethylene tadalafil is a metabolite of Tadalafil that primarily functions as a selective inhibitor of phosphodiesterase type 5 (PDE5). This compound is significant in studies investigating the pharmacokinetics and metabolic pathways of Tadalafil, as well as its potential implications in conditions associated with erectile dysfunction and pulmonary hypertension. Its role in enzymatic metabolism, primarily mediated by CYP3A4, makes it relevant for research focused on drug-drug interactions and personalized medicine.

Cat. No.

A70721

CAS No.

172152-37-3

Ilaprazole sulfone

Ilaprazole sulfone is the primary metabolite of Ilaprazole, primarily formed through the activity of cytochrome P450 enzymes CYP3A4 and CYP3A5. As a metabolite of an oral proton pump inhibitor, Ilaprazole sulfone holds relevance in pharmacokinetic studies and the evaluation of drug interactions. Its examination may provide insights into the efficacy and safety profiles of proton pump inhibitors in clinical settings.

Cat. No.

A70744

CAS No.

265989-44-4

4-Hydroxy atorvastatin hemicalcium

4-Hydroxy atorvastatin hemicalcium is a metabolite of the widely studied HMG-CoA reductase inhibitor, atorvastatin. This compound exhibits significant lipid-lowering activity, contributing to the therapeutic efficacy of atorvastatin in managing hyperlipidemia. Research applications include studying the metabolic pathways of atorvastatin and evaluating its pharmacokinetic properties in various biological systems.

Cat. No.

A70752

CAS No.

180634-64-4

Masoprocol tetrapivalate

Synonyms: Nordihydroguaiaretic acid tetrapivalate

Masoprocol tetrapivalate is a catecholic butane metabolite that functions as an inhibitor of tyrosine kinase activity, specifically targeting IGF-1R and EGFR pathways. This compound regulates tyrosine kinase signaling involved in cell proliferation, making it a valuable reagent in studies of proliferative diseases, including malignant, precancerous, and benign cancers, as well as solid tumors. Its use in research may help elucidate the mechanisms underlying these conditions and aid in the development of therapeutic strategies.

Cat. No.

A70764

CAS No.

2377533-92-9

2-Formyl sunitinib

2-Formyl sunitinib is a metabolite of the tyrosine kinase inhibitor sunitinib, primarily involved in modulating cellular signaling pathways. This compound demonstrates significant biological activity in cancer research, particularly in studying the effects of sunitinib metabolism on tumor growth and response. Its application in experimental models can provide insights into the mechanisms of action and therapeutic implications of tyrosine kinase inhibitors in oncology.

Cat. No.

A70765

CAS No.

2715981-74-9

Alpelisib carboxylic acid

Alpelisib carboxylic acid is the principal metabolite of Alpelisib, a selective PI3K inhibitor targeting the p110α isoform. This compound plays a crucial role in understanding the pharmacokinetics and biological effects of Alpelisib in various cancer models. Its analysis is valuable in research related to cancer therapy and the evaluation of PI3K pathway modulation.

Cat. No.

A70796

CAS No.

101901-07-9

7-Hydroxy etodolac

Synonyms: 7-OH-ET

7-Hydroxy etodolac is a metabolite of etodolac, a non-steroidal anti-inflammatory drug that functions as a cyclooxygenase (COX) inhibitor. This compound is of interest in pharmacokinetic studies and metabolism research, providing insights into the metabolic pathways of NSAIDs. Its investigation can enhance the understanding of drug efficacy and safety profiles in therapeutic applications.

Cat. No.

A70809

CAS No.

60324-59-6

Nomelidine

Nomelidine is a metabolite of Zimelidine that primarily acts as a serotonin reuptake inhibitor. It demonstrates notable antidepressant and analgesic properties, making it valuable for research involving mood disorders and pain management. This compound is suitable for studies focused on the pharmacological effects of antidepressants and their mechanisms of action.

Cat. No.

A70827

CAS No.

406484-24-0

JANEX-1-M

JANEX-1-M is a metabolite of JANEX-1, a selective inhibitor of Janus kinase 3 (JAK3). This compound is known to effectively inhibit mast cell degranulation and the subsequent release of pro-inflammatory mediators. JANEX-1-M is utilized in research focused on inflammatory responses and the modulation of immune system activity.