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All Dyes is the single product list for the Fluorescent Dyes, Probes & Stains section. Many dyes here have no application or dye-family subcategory, so the list is the broadest way to browse the range. It suits searches by product name when the required dye is already known. Examples range from the near-infrared cyanine indocyanine green and the ratiometric calcium indicator Fura-2 pentapotassium to the nucleic acid stains Hoechst 33258 trihydrochloride and SYBR Green II. Classical stains such as hematoxylin, reactive labeling dyes and enzyme substrates are listed alongside them. For selection by task or by core structure, the parent Fluorescent Dyes, Probes & Stains page groups dyes by application and dye family.
Synonyms: Bz-Arg-Gly-Phe-Phe-Leu-4MβNA
Bz-RGFFL-4MβNA is a fluorogenic peptide substrate with the sequence Bz-Arg-Gly-Phe-Phe-Leu-4MβNA. This compound is designed for use in enzymatic assays and can facilitate the study of protease activity. Its unique fluorescent properties allow for sensitive detection and quantification in various biological research applications, providing valuable insights into cellular processes and enzyme kinetics.
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ASMI is a ratiometric, two-photon excited fluorescent probe that targets mitochondrial cysteine. It features a biocompatible merocyanine fluorophore and an acrylate moiety for selective thiol reactivity. ASMI enables high-contrast, bright imaging of living cells and intact tissues, with a depth of up to 150 μm, facilitating rapid monitoring of cellular redox states. The probe exhibits a two-photon action cross section (Φσmax) of 65.2 GM at an excitation wavelength (λex) of 740 nm, making it suitable for advanced fluorescence microscopy applications.
Z-Val-Lys-Met-AMC is a fluorescent substrate designed to detect β-secretase activity, specifically targeting cathepsin B. This compound can be utilized in research applications focused on Alzheimer's disease and other neurodegenerative disorders, facilitating the study of proteolytic enzymes involved in pathogenesis. The fluorescent nature of this substrate allows for easy monitoring and quantification of enzyme activity in vitro.
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Ac-Gly-Pro-AFC is a fluorogenic substrate specifically designed to assess fibroblast activation protein (FAP) endopeptidase activity. This compound exhibits high sensitivity and selectivity, making it useful for studying FAP's role in tumor microenvironments and fibrosis. It is applicable in various research domains, including cancer biology and tissue remodeling studies, facilitating the quantification of enzymatic activity in biological samples.
FITC-YVADAPK(Dnp) is a fluorogenic substrate primarily used to study caspase-1 activity. Upon cleavage by caspase-1, the fluorescence intensity increases, allowing for quantitative analysis of enzyme activity in various biological samples. This reagent is suitable for applications in apoptosis research and the investigation of inflammatory responses.
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M-H2S is an endoplasmic reticulum-targeted near-infrared fluorescent probe designed for the selective detection of hydrogen sulfide (H₂S) in living cells and zebrafish. With a detection limit of 39.1 nM, M-H2S demonstrates a linear fluorescence intensity ratio response (F₆₅₀/F₅₆₀) over a concentration range of 0-40 μM, optimized for physiological pH conditions (7.2). This probe is particularly valuable for investigating the role of H₂S in endoplasmic reticulum functionality, cellular stress responses, and associated pathological conditions.
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Meso-Cl cyanine 7.5 free acid chloride is a fluorescent dye primarily targeting amine groups in biological molecules. This reagent effectively labels antibodies, nucleic acids, and proteins, enabling detailed studies in various applications, including microscopy and flow cytometry. With excitation and emission wavelengths of 815 nm and 825 nm, respectively, it provides high sensitivity and versatility for fluorescence detection techniques in chemical research.
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Cyanine 5.5 DBCO chloride is a versatile click chemistry reagent featuring a cycloalkyne moiety that enables efficient, copper-free bioconjugation. This compound serves as a linker for the Cyanine 5.5 fluorophore, providing excellent stability and fast reaction kinetics. With excitation and emission wavelengths of 680 nm and 715 nm, respectively, it is ideal for applications in fluorescent imaging and labeling of lipids and biomolecules in various biological research contexts.
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Ac-VDVAD-AFC is a caspase-specific fluorescent substrate designed for the detection of caspase-3 and caspase-2 activities. This reagent serves as a valuable tool for studying apoptosis and investigating mechanisms involved in tumorigenesis and cancer progression. Its fluorescent properties enable quantitative measurement, facilitating research in cell death and therapeutic responses in cancer models.
(BHQ-3)-OSu hexafluorophosphate is a chemical reagent employed in fluorescent labeling of protease substrates. It serves as a vital tool for investigating protease activity, enabling precise tracking and measurement through fluorescence detection. This compound is particularly useful in applications involving cell biology, biochemistry, and molecular research, facilitating the study of enzyme kinetics and signaling pathways.
Ac-Arg-Gly-Lys-AMC is a fluorogenic substrate specifically designed for the assessment of protease activity. Upon hydrolysis by active proteases, it releases the fluorescent compound 7-amino-4-methylcoumarin (AMC), which exhibits strong fluorescence when exposed to UV light. This reagent is instrumental in various biochemical assays and applications focused on studying protease function and regulation.
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ONOO-/O2- Tracker Probe is a dual-responsive near-infrared fluorescent probe designed to selectively detect peroxynitrite (ONOO⁻) and superoxide anion (O₂•⁻) simultaneously. This probe emits a strong fluorescence signal only in the presence of both reactive oxygen and nitrogen species, making it an effective tool for monitoring oxidative stress in biological systems. Research applications include assessing drug-induced liver injury (DILI) and studying other conditions associated with oxidative damage.
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18:1 Bromo-squareFluor (632/649) PE ammonium is a fluorescent lipid designed for membrane visualization with excitation and emission wavelengths of 632 nm and 649 nm, respectively. This compound serves as a valuable tool in imaging applications, enabling researchers to study cellular membranes and lipid interactions in various biological contexts. Its fluorescent properties make it suitable for use in fluorescence microscopy and related techniques.
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1,2-Dimethylpyridinium iodide-Bodipy is a fluorescent probe designed for the selective detection of hydrogen sulfide (H2S). This compound exhibits notable fluorescence response upon H2S activation, emitting near-infrared light at 718 nm. Its unique self-assembled structure enhances its sensitivity and biocompatibility, making it suitable for real-time imaging and monitoring of H2S levels in biological research applications.
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BAY-771 is a pyrimidinedione-based chemical probe that exhibits favorable lead-like properties and high permeability in Caco-2 cell assays, indicating the absence of efflux. It demonstrates negligible inhibitory activity against BCAT1 and shows no activity towards BCAT2, making it suitable as a negative control for BAY-069. BAY-771 is primarily utilized in research related to tumor metabolism, aiding in the investigation of metabolic pathways in cancer.
Bromophenol red sodium is a fluorescent dye that serves as a chemical indicator. It has been shown to bind to lysozyme, inhibiting its enzymatic activity against the bacterial cell wall, while not affecting the polysaccharide component of peptidoglycan. This dual functionality makes it useful for studying enzyme interactions and bacterial cell wall composition in various biochemical research applications.
C4 BODIPY 505/515 MG is a fluorescently labeled glycerolipid that exhibits excitation and emission maxima at 495 nm and 503 nm, respectively. This compound is primarily used as a fluorescent lipid probe for studying membrane dynamics and lipid interactions in biological systems. Its bright fluorescence allows for effective visualization in various biological research applications, including live-cell imaging and lipid metabolism studies.
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Ac-LETD-AFC is a fluorogenic substrate specifically designed for the quantification of caspase-8 activity. This compound enables the measurement of caspase-8-mediated proteolytic activity, serving as a valuable tool for studying cancer cell apoptosis and oxidative stress metabolism. Its application supports research in cellular signaling pathways related to programmed cell death and various stress responses.
Talogreptide mesaroxetan is a diagnostic imaging agent primarily utilized for enhanced visualization in imaging techniques. It exhibits antineoplastic properties, making it valuable in cancer research and diagnostics. This compound aids in the identification and characterization of tumors, facilitating improved patient management and treatment planning. Its application in imaging studies contributes significantly to the understanding of oncological processes.
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Ac-WVAD-AMC is a fluorogenic substrate specifically designed to target caspase 1. This compound enables the quantitative measurement of caspase 1 enzymatic activity through fluorescence detection. Its utility in various biological research applications includes studies on apoptosis, inflammation, and cell death pathways, making it a valuable tool for investigating the role of caspases in cellular processes.
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Sulfo-Cy3(Me)COOH potassium is a sulfo-Cyanine 3 derivative designed as a fluorescent dye. This compound exhibits strong orange fluorescence, making it suitable for labeling proteins and nucleic acids with an excitation wavelength of 554 nm and an emission wavelength of 568 nm. It is commonly utilized in various biological applications, including fluorescence microscopy and flow cytometry, facilitating the visualization and tracking of biomolecules in research studies.
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Lyso-laurdan is a fluorescent lipid probe that targets lysosomal membranes. It features a morpholine group that enables its accumulation in lysosomes through protonation, allowing it to adopt a cationic form in the acidic environment of these organelles. This localization facilitates the investigation of lysosomal membrane properties and dynamics, making it a valuable tool for researchers studying lysosomal function and related cellular processes.
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Abz-GFDPFRQ-EDDnp is a fluorogenic substrate targeting metallothionein oligopeptidase, with excitation and emission wavelengths of 320 nm and 420 nm, respectively. This compound is instrumental in assessing the enzymatic activity of metallothionein oligopeptidase in tissue extracts. Its applications extend to research studies focused on temporal lobe epilepsy, facilitating insights into the enzyme's role in neurological processes.
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MeOSuc-Ala-Ala-Pro-Val-4-MNA is a fluorogenic substrate specifically designed for the detection of elastase activity. Upon enzymatic cleavage, it emits fluorescence detectable at 425 nm with an excitation wavelength of 340 nm. This compound is valuable for research applications involving protease activity assays and can aid in the study of various pathologies where elastase plays a key role.
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Cyanine 3.5 maleimide chloride is a fluorescent dye that targets thiol groups in proteins for specific labeling applications. It exhibits advantageous properties, including a long wavelength, adjustable absorption and emission spectra, high extinction coefficient, and good water solubility. This dye is commonly utilized in the labeling of proteins, antibodies, and small molecular compounds, facilitating the study of protein dynamics and interactions through fluorescence techniques. The labeling process is straightforward, typically involving a simple mixing reaction with the target biomolecule.
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