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Acetyl-CoA carboxylase (ACC) inhibitors block the first committed step of fatty acid synthesis. The biotin-dependent enzyme carboxylates acetyl-CoA to malonyl-CoA, the two-carbon donor used by fatty acid synthase. Cytosolic ACC1 supplies malonyl-CoA for de novo lipogenesis, mainly in liver and adipose tissue. ACC2 sits at the outer mitochondrial membrane, where its product restrains fatty acid oxidation. Mice lacking ACC2 oxidize fatty acids continuously and store less fat. Inhibitors are studied in models of hepatic steatosis, insulin resistance and lipid-dependent tumor growth, including non-small-cell lung cancer. TOFA, CP-640186, ND-646 and firsocostat (ND-630) are among the listed compounds.
Gigantetrocin is an inhibitor of Acetyl-CoA Carboxylase, a key enzyme in fatty acid biosynthesis. This compound has demonstrated bioactivity in modulating lipid metabolism and has potential applications in metabolic research, specifically in the study of obesity and related diseases. Its ability to regulate lipid synthesis makes it a valuable tool for investigating pathways associated with energy homeostasis and metabolic disorders.
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CKBA is an acetyl-CoA carboxylase 1 (ACC1) inhibitor, exhibiting an IC50 of 5.02 μM. This compound effectively inhibits the differentiation of Th17 cells, with IC50 values of 3.28 μM in mouse cells and 3.61 μM in human cells. In preclinical models, CKBA ointment significantly reduces psoriasis-like inflammation in mice, making it a valuable tool for investigating psoriasis and related inflammatory disorders.
Synonyms: Dichlorfop acid; (±)-Diclofop
Diclofop is an acetyl-CoA carboxylase (ACC) inhibitor, serving as an important metabolite of the herbicide diclofop-methyl. In addition to its herbicidal properties, Diclofop demonstrates antimalarial activity, with an IC50 value of 210 μM against Plasmodium falciparum. This compound can be utilized in research to explore mechanisms of ACC inhibition and its potential therapeutic applications in malaria treatment.
