Endogenous Metabolite

Cat. No.

A74258

CAS No.

2055172-61-5

(S)-KT109

(S)-KT109 is a selective inhibitor of diacylglycerol lipase β (DAGLβ), exhibiting an IC50 of 39.81 nM. This compound demonstrates lower inhibitory effects on DAGLα, with an IC50 of 794.3 nM, and shows reduced activity against α/β-amidase domain-containing 6 (ABHD6) at an IC50 of 630.9 nM. (S)-KT109 is valuable for research investigating the roles of endocannabinoids in various biological pathways, particularly those involving lipids and neurobiology.

Cat. No.

A74268

CAS No.

10219-69-9

(R)-Coriolic acid

Synonyms: 13(R)-HODE

(R)-Coriolic acid is an endogenous metabolite derived from the metabolism of linoleic acid through the action of lipoxygenase. It has been identified in the supernatants and membranes of cultured bovine endothelial cells, reflecting its role in COX-mediated pathways. Additionally, (R)-Coriolic acid is recognized as a weak inhibitor of U-46619-induced platelet aggregation, with an IC50 of 2.7 µM. This compound is valuable for research on lipid metabolism, cardiovascular function, and platelet biology.

Cat. No.

A74292

CAS No.

481-70-9

Endocrocin

Endocrocin is an anthraquinone and a notable fungal secondary metabolite. It functions primarily as a chemotaxis inhibitor, exhibiting significant immunosuppressive properties. This compound is valuable in research focused on immune response modulation and the study of fungal-derived metabolites in therapeutic applications.

Cat. No.

A74318

CAS No.

105462-23-5

NE58018

NE58018 is a potent inhibitor of bone resorption, primarily targeting Farnesyl pyrophosphate synthase (FPPS). This compound demonstrates enhanced inhibitory activity due to its structural features and the presence of aminophosphonates. NE58018 modulates the interactions of Thr201 and Tyr204 residues, which are critical for substrate binding and catalysis, thereby increasing the overall inhibition of FPPS. It is useful in research related to bone metabolism and related disorders.

Cat. No.

A74352

CAS No.

140112-65-8

Oleic Acid-2,6-diisopropylanilide

Oleic Acid-2,6-diisopropylanilide is a potent inhibitor of acylCoA:cholesterol acyltransferase (ACAT), a key enzyme involved in the synthesis of cholesteryl esters related to dietary cholesterol absorption, with an IC50 of 7 nM. This compound has demonstrated biological activity by lowering low-density lipoproteins and increasing high-density lipoprotein levels in animal models subjected to high-fat, high-cholesterol diets. It serves as a valuable tool in research applications focused on lipid metabolism and cardiovascular disease.

Cat. No.

A74368

CAS No.

309913-51-7

Scio-323

Scio-323 is an orally active inhibitor of the p38 mitogen-activated protein kinase (MAPK), primarily targeting chronic inflammatory responses linked to polyethylene particles. This compound has demonstrated the ability to reduce inflammation; however, it shows minimal impact on bone formation during such responses. Notably, Scio-323 treatment does not enhance bone growth in the presence of polyethylene particles, and osteoblast-like activity remains suppressed. This positions Scio-323 as a significant candidate for research into chronic inflammatory conditions affecting bone metabolism.

Cat. No.

A74397

CAS No.

483369-58-0

Denagliptin

Synonyms: GSK823093

Denagliptin is a small molecule inhibitor of dipeptidyl peptidase IV (DPP-4), primarily targeting endogenous metabolites involved in glucose metabolism. This compound demonstrates significant activity in the research of type 2 diabetes and offers insights into endocrine and metabolic disorders. While stable in the solid state, Denagliptin is known to degrade in solution and in various excipient mixtures, with degradation primarily occurring through cyclization reactions. Understanding its degradation pathways is crucial for advancing formulation development and regulatory compliance.

Cat. No.

A74419

CAS No.

1162665-52-2

IDX375

IDX375 is a selective non-nucleoside inhibitor targeting the Hepatitis C Virus (HCV) NS5B polymerase. This compound exhibits potent inhibitory activity primarily against HCV genotypes 1a and 1b. The binding interactions and structural conformation of IDX375 have been validated through X-ray co-crystallization studies, providing insight into its mechanism of action. This reagent is useful for research applications focusing on HCV replication and therapeutic development.

Cat. No.

B20253

CAS No.

1643852-84-9

AGI-16903

AGI-16903 is a metabolite of Enasidenib, functioning as a reversible and selective inhibitor of mutant isocitrate dehydrogenase 2 (IDH2) enzymes. It exhibits IC50 values of 100 nM and 400 nM for IDH2R140Q and IDH2R172K variants, respectively. This compound is primarily used in cancer research, particularly in studies focused on IDH2 mutations and their role in tumorigenesis.

Cat. No.

B21392

CAS No.

645-35-2

L-Hisidine (monohydrocholoride)

L-Histidine (monohydrochloride) is an essential amino acid that serves as a critical endogenous metabolite, particularly for infants. It plays a role in various biological processes and functions as an inhibitor of mitochondrial glutamine transport. This compound is frequently used in research applications involving amino acid metabolism, cellular signaling pathways, and neurotransmitter synthesis.

Cat. No.

B21667

CAS No.

591-59-3

DL-Glyceraldehyde 3-phosphate

DL-Glyceraldehyde 3-phosphate is a critical endogenous metabolite that serves as an intermediate in glycolysis and gluconeogenesis pathways. This compound exhibits potent inhibitory effects on the growth of Escherichia coli, highlighting its potential role in microbiological research. Additionally, DL-Glyceraldehyde 3-phosphate acts as a competitive inhibitor of acyltransferase, making it valuable for studies on metabolic regulation and enzyme kinetics.