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Fatty Acid Synthase (FASN)

Fatty acid synthase (FASN) inhibitors block the enzyme that assembles palmitate from acetyl and malonyl units. FASN is a large homodimeric protein that carries all catalytic steps of fatty acid synthesis on one polypeptide chain. Many tumor cells express high FASN levels and rely on de novo lipogenesis, so the enzyme is studied in cancer metabolism. C75, a synthetic α-methylene-γ-butyrolactone, was described in 2000 as a FASN inhibitor tested in xenografts. Orlistat, known as a pancreatic lipase inhibitor, was shown in 2004 to inhibit the thioesterase domain of FASN. Denifanstat, TVB-3166 and TVB-3664 are later reversible FASN inhibitors from a related chemical series. The list also includes natural products reported to inhibit FASN, such as dihydrocurcumin and praeruptorin B.

Items 26-28 of 28

  • GSK837149A
    Cat. No.
    A74839
    CAS No.
    13616-29-0

    GSK837149A

    GSK837149A is a selective inhibitor of human Fatty Acid Synthase (FASN), specifically targeting the KR domain. It exhibits reversible inhibition with a high affinity for type I FASN (Ki = 30 nM), functioning as a competitive inhibitor of NADPH and a non-competitive inhibitor of acetoacetyl-CoA. GSK837149A is applicable in research exploring obesity and breast cancer, providing valuable insights into metabolic regulation and tumorigenesis.

    In stock View Details
    1 mg
    $60.00
    5 mg
    $180.00
    All 2 sizes
  • FASN-IN-3
    Cat. No.
    A74840
    CAS No.
    2097262-60-5

    FASN-IN-3

    FASN-IN-3 is a potent inhibitor of fatty acid synthase (FASN), a critical enzyme in lipid biosynthesis. This compound is particularly useful for investigating the role of FASN in metabolic disorders and cancer, where altered fatty acid metabolism is a key feature. Research applications include studies on cellular proliferation and survival in FASN-dependent cancer cell lines, as well as assays evaluating the impact of lipid synthesis inhibition on cellular signaling pathways.

    In stock View Details
    1 mg
    $35.00
    5 mg
    $80.00
    All 7 sizes
  • (-)-C75 (l-C75)
    Cat. No.
    A74845
    CAS No.
    1234694-22-4

    (-)-C75 (l-C75)

    (−)-C75 is a synthetic inhibitor of fatty acid synthase (FASN) that effectively inhibits the growth of prostate cancer cells, such as PC3, with an IC50 of 35 µM. Additionally, (−)-C75 acts as a potent activator of carnitine palmitoyltransferase 1A (CPT1A). This compound is valuable for research applications focused on cancer metabolism and therapeutic strategies targeting lipid biosynthesis.

    In stock View Details
    1 mg
    $470.00
    5 mg
    $1,445.00
    All 2 sizes

Items 26-28 of 28

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