Glutaminase

Cat. No.

A74977

CAS No.

2508-89-6

Duazomycin

Synonyms: Duazomycin A

Duazomycin is a glutamine antagonist that plays a critical role in modulating metabolic pathways. This compound significantly enhances the efficacy of 6-Mercaptopurine in experimental allergic encephalomyelitis models, demonstrating improved therapeutic outcomes without elevating toxicity. Duazomycin is valuable for research applications focusing on metabolic interactions and therapeutic strategies in autoimmune diseases.

Cat. No.

A74978

CAS No.

2839447-07-1

Duazomycin sodium

Synonyms: Duazomycin A sodium

Duazomycin sodium is a potent glutamine antagonist that enhances the efficacy of 6-Mercaptopurine in models of experimental allergic encephalomyelitis (EAE). By targeting glutamine metabolism, it demonstrates potential to improve therapeutic outcomes while maintaining a favorable toxicity profile. This compound is valuable for research applications focused on neuroinflammatory disorders and the modulation of immune responses.

Cat. No.

A74982

CAS No.

2435781-94-3

GLS1 Inhibitor-3

GLS1 Inhibitor-3 is a potent inhibitor of glutaminase 1 (GLS1) with an IC50 value of 27.98 nM. This compound exhibits significant antiproliferative activity, making it a valuable tool for research into metabolic reprogramming in cancer cells. Its selective inhibition of GLS1 may facilitate investigations into glutamine metabolism and its role in tumor growth and survival.

Cat. No.

A74984

CAS No.

1439390-05-2

Glutaminase-IN-4

Glutaminase-IN-4 is a potent inhibitor of glutaminase (GLS) with an IC50 of 2.3 μM. This compound exhibits significant potential in metabolic research by inhibiting glutamine metabolism, which is crucial for the growth and survival of certain cancer cells. Its application in studies exploring the roles of glutaminase in tumorigenesis and various metabolic disorders makes it a valuable tool for researchers investigating cellular energy pathways and cancer metabolism.

Cat. No.

A74988

CAS No.

64199-78-6

Barbinervic acid

Barbinervic acid is a potent glutaminase inhibitor, exhibiting an IC50 of 14 μM. This compound is valuable for research into neurodegenerative diseases, as it modulates glutamine metabolism, which is often dysregulated in various neurological disorders. Its application in biochemical studies can enhance the understanding of neuroprotective mechanisms and therapeutic strategies.

Cat. No.

A74991

CAS No.

104741-27-7

THDP17

THDP17 is an orally active inhibitor of glutaminase, a key enzyme in the glutamine metabolic pathway. By inhibiting glutaminase, THDP17 effectively reduces ammonia production, making it a valuable tool in studying conditions associated with elevated ammonia levels. This compound is particularly relevant for research in metabolic disorders and cancer metabolism, where glutamine dependence plays a critical role.

Cat. No.

B18089

CAS No.

2079939-05-0

Sirpiglenastat

Synonyms: DRP-104

Sirpiglenastat is a broad-spectrum glutamine antagonist that disrupts tumor metabolism. By targeting glutamine utilization, Sirpiglenastat exhibits significant anticancer effects while simultaneously enhancing the antitumor immune response. This compound is valuable for researchers investigating metabolic pathways in cancer and immune modulation.