All Dyes

Cat. No.

A70761

CAS No.

66164-06-5

N-Didesmethyl Loperamide

Synonyms: R 21345

N-Didesmethyl Loperamide is a metabolite of Loperamide and serves as an innovative PET radiotracer specifically designed for visualizing P-glycoprotein (P-gp) function in vivo. This compound contributes to the understanding of drug transport mechanisms and can enhance insights into multidrug resistance in various diseases, particularly in cancer research. Its application in PET imaging provides valuable information for both pharmacological studies and the development of therapeutic strategies targeting P-gp.

Cat. No.

A71215

CAS No.

856699-18-8

Biliverdin hydrochloride

Biliverdin hydrochloride is a tetrapyrrolic pigment involved in the catabolism of heme. This compound serves as a precursor to bilirubin through the action of biliverdin reductase and has been identified as possessing anti-mutagenic, antioxidant, anti-inflammatory, and immunosuppressive properties. Its diverse biological activities make biliverdin hydrochloride valuable for research applications in oxidative stress, cellular signaling, and inflammation studies.

Cat. No.

A71330

CAS No.

360-68-9

Coprostanol

Synonyms: 5β-Cholestan-3β-ol

Coprostanol, also known as 5β-Cholestan-3β-ol, is an indicator sterol that forms through the microbial reduction of cholesterol in the intestines of humans and higher animals. It serves as a valuable marker for assessing fecal pollution in water resources, particularly in relation to sewage discharges. Additionally, coprostanol may act as a potential biological indicator for conditions such as cerebral chondrodystrophy (CTX), making it relevant for various environmental and biomedical research applications.

Cat. No.

A71840

CAS No.

18499-84-8

Flavokermesic acid

Flavokermesic acid is an anthraquinone dye primarily found in extracts of the Diaspididae family of insects. It serves as a valuable tool for studying the biosynthetic pathways associated with insect-derived anthraquinone pigments, contributing to insights into pigment production and its biological significance. This compound is utilized in various research applications focused on natural product chemistry and insect biology.

Cat. No.

A72492

CAS No.

187099-99-6

Sulforhodamine 101 DHPE

Sulforhodamine 101 DHPE is a fluorescent probe that targets endogenous metabolites through its unique conjugation of the phospholipid 1,2-dipalmitoyl-sn-glycero-3-PE with sulforhodamine 101, a red fluorescent dye exhibiting excitation/emission maxima of 586/605 nm. This reagent is well-suited for applications including imaging of solid-supported lipid bilayers, detection of protein-ligand interactions on bilayer surfaces, and monitoring the colocalization of lipid probes in liposomes using resonance energy transfer (RET) techniques. Its ability to integrate into phospholipid bilayers enhances its utility in membrane biophysics research.

Cat. No.

A72877

CAS No.

103659-08-1

NMTCA

Synonyms: NMTPRO; N-Nitroso-2-methylthiazolidine 4-carboxylic acid; N-nitrosomethylthioproline

NMTCA (N-methyl-N'-thiocarbamoyl-L-arginine) is a sulfur-containing N-nitrosamino acid that serves as an indicator of endogenous nitrosation. Its primary application includes the assessment of nitrosation levels through gas chromatography-thermal energy analysis. NMTCA is valuable in biochemical research for studying the effects of nitrosative stress and related biological processes.

Cat. No.

A73431

CAS No.

168912-70-7

Cholylglycylamidofluorescein

Synonyms: CGamF

Cholylglycylamidofluorescein (CGamF) is a fluorescent probe designed to study hepatic bile acid transport mechanisms. This compound is composed of cholic acid linked through a glycylamino bond to fluorescein, offering a fluorescence excitation/emission maxima at 492/515 nm in aqueous solutions. CGamF is utilized in research applications involving bile acid metabolism and transport processes within liver cells, enabling in-depth studies of hepatic function and pathology.

Cat. No.

A74214

CAS No.

957494-27-8

Biotin (5-fluorescein) conjugate

Synonyms: N-(Fluorescein-5-carbamidoethyl)biotinamide

Biotin (5-fluorescein) conjugate is a fluorescently labeled biotin derivative designed for effective cell labeling. This compound exhibits high biological activity in detecting and localizing target molecules in various biomedical research applications. It is particularly useful in immunofluorescence staining experiments, enhancing both sensitivity and specificity in the visualization of biomolecular interactions.

Cat. No.

A74254

CAS No.

62037-41-6

Ala-Ala-Phe-AMC

Ala-Ala-Phe-AMC is a fluorogenic substrate primarily used for the detection of proteolytic activity. Its positively charged characteristics enhance its suitability for various biochemical assays, enabling researchers to investigate protease function in biological samples. This compound is valuable in studies related to protein turnover, cellular signaling, and disease mechanisms involving proteolysis.

Cat. No.

A74389

CAS No.

78377-23-8

PDAM

Synonyms: 1-Pyrenyldiazomethane

PDAM (1-Pyrenyldiazomethane) is a fluorescent dye known for its strong biomarker properties and fluorescence activity. It is utilized in cell imaging for histological studies, allowing for clear delineation of specific cell structures. Additionally, PDAM serves as a hematological stain, enhancing the visualization of cellular components to facilitate more accurate diagnoses in various research applications.

Cat. No.

A74701

CAS No.

65147-06-0

Boc-Ile-Glu-Gly-Arg-AMC

Synonyms: IEGR-AMC

Boc-Ile-Glu-Gly-Arg-AMC is a fluorogenic peptide substrate specifically designed for the activated factor X (FXa). This compound exhibits key biological activity by enabling the quantification of FXa in various biological assays. It is particularly useful in research applications focused on coagulation, thrombin generation, and related hemostatic studies.

Cat. No.

A74990

CAS No.

3031522-14-9

HB-230

HB-230 is a red fluorescent probe designed specifically for transglutaminase 2 (TG2). It effectively binds to TG2 and α2-macroglobulin through the LRP1 pathway, facilitating efficient endocytosis. HB-230 exhibits excitation and emission wavelengths of 649 nm and 665 nm, respectively, making it suitable for imaging applications in studies involving TG2. This reagent is valuable for researchers investigating cellular processes associated with TG2 activity.

Cat. No.

A75029

CAS No.

18997-57-4

4-Methylumbelliferyl β-D-Glucopyranoside

4-Methylumbelliferyl β-D-Glucopyranoside serves as a fluorogenic substrate specifically for β-glucosidase, facilitating the measurement of β-glucosidase activity in various biological assays. Upon enzymatic cleavage, it releases 4-methylumbelliferone, a highly fluorescent compound with an emission maximum between 445-454 nm. The excitation wavelength of 4-methylumbelliferone is influenced by pH, showing peaks at 330, 370, and 385 nm at pH 4.6, 7.4, and 10.4, respectively, making it a valuable tool for studying enzyme kinetics and related research applications.

Cat. No.

A75051

CAS No.

17833-43-1

4-Methylumbelliferyl-α-D-Glucopyranoside

Synonyms: 4-Methylumbelliferyl-α-D-Glucose; 4-Methylumbelliferyl-α-D-Glucoside; 4-MU-α-D-Glucopyranoside

4-Methylumbelliferyl-α-D-Glucopyranoside is a fluorescent substrate targeting α-glucosidase, which releases the fluorescent moiety 4-methylumbelliferyl (4-MU) upon enzymatic cleavage. This compound exhibits pH-dependent fluorescence, with excitation wavelengths of 320 nm in acidic conditions and 360 nm in alkaline conditions, while its emission increases between 445-455 nm as pH decreases. 4-Methylumbelliferyl-α-D-Glucopyranoside serves as a valuable biomarker for assessing α-glucosidase activity in infant blood spot samples, particularly in the context of Fabry and Pompe diseases.

Cat. No.

A75144

CAS No.

3036456-18-2

NIR-BG2

NIR-BG2 is a near-infrared fluorescent probe that selectively targets senescence-associated β-galactosidase (SA-β-Gal). Upon activation by SA-β-Gal, NIR-BG2 undergoes hydrolysis to release an electrophilic quinone methide, which covalently labels surrounding proteins, resulting in a 16-fold increase in fluorescence intensity at 709 nm. This compound is valuable for in vivo imaging studies focused on cellular senescence, enabling researchers to visualize senescent cells effectively.

Cat. No.

A75532

CAS No.

61419-02-1

Naphthofluorescein

Synonyms: Naphthafluorescein

Naphthofluorescein is a potent inhibitor of HIF-1 through the inhibition of HIF prolyl-hydroxylase activity. It effectively suppresses Mint3-dependent HIF-1 signaling and glycolytic activity in cancer cells and macrophages while exhibiting low cytotoxicity in vitro and negligible adverse effects in vivo. Additionally, Naphthofluorescein serves as a fluorescent pH-sensitive probe, making it suitable for functional Cerenkov imaging applications.

Cat. No.

A75988

CAS No.

384833-00-5

18:1 Liss Rhod PE

Synonyms: 18:1 Lissamine rhodamine PE

18:1 Liss Rhod PE is a fluorescent phospholipid used as a fluorescent probe. It is highly effective for monitoring dip-pen nanolithography-generated structures through fluorescence microscopy, facilitating large-scale imaging of phospholipid inks. Additionally, 18:1 Liss Rhod PE exhibits phase separation and self-quenching behavior under specific conditions in thin lipid membrane stacks, making it valuable for studies of membrane dynamics and organization.

Cat. No.

A76532

CAS No.

2374144-23-5

FITC-GW3965

FITC-GW3965 is a fluorescence-labeled agonist of liver X receptor beta (LXRβ), designed to facilitate the study of LXRβ functions in biological systems. The compound is synthesized by replacing the trifluoromethyl group of GW3965 with an amide linkage to incorporate the FITC dye. FITC-GW3965 is valuable for research applications involving the exploration of lipid metabolism, cholesterol homeostasis, and gene regulation mediated by LXRβ.

Cat. No.

A76550

CAS No.

2301865-01-8

(S)-DO271

(S)-DO271 is a non-active control probe designed for targeting Abhydrolase Domain Containing 12 (ABHD12), exhibiting minimal inhibitory activity with an IC50 greater than 100 μM. This compound shows no cytotoxic effects and does not induce the upregulation of inflammatory factors, making it an effective negative control for validating functional studies of ABHD12. Its use is critical in distinguishing specific activity in ABHD12-related research applications.

Cat. No.

A76554

CAS No.

161180-11-6

7-Hydroxycoumarinyl arachidonate

Synonyms: 7-HCA; Umbelliferyl Arachidonate; 7-HC-arachidonate

7-Hydroxycoumarinyl arachidonate is a fluorogenic substrate for cytosolic phospholipase A2 (PLA2) and monoacylglycerol lipase (MAGL). Upon hydrolysis, it generates arachidonic acid (AA) and the highly fluorescent product 7-hydroxyl coumarin (7-HC). The production of 7-HC can be quantitatively assessed using a fluorometer, making this compound valuable for studies investigating the enzymatic activity of PLA2 and MAGL in various biological contexts.

Cat. No.

A76593

CAS No.

259176-74-4

Ac-LVSR-AMC

Ac-LVSR-AMC is a tetrapeptide fluorescent substrate designed to quantitatively assess the specific activity of Malt1 protease in vitro. This compound serves as a valuable tool for studying proteolytic processes and Malt1-related signaling pathways. Its fluorogenic properties enable sensitive detection, making it suitable for applications in biochemical assays and research on immune responses.

Cat. No.

A76727

CAS No.

2741190-31-6

Coumarin–quinone conjugate

Coumarin-quinone conjugate acts as a fluorescent substrate specifically for NADH:ubiquinone oxidoreductases, featuring a coumarin fluorophore linked to a ubiquinone analog. This reagent facilitates the measurement of kinetic parameters for AIFM2/FSP1, making it valuable in research focused on ferroptosis and related metabolic processes. Its fluorescent properties enhance detection sensitivity in various biochemical assays.

Cat. No.

A76832

CAS No.

192723-42-5

Mca-PLAQAV-Dpa-RSSSR-NH2

Mca-PLAQAV-Dpa-RSSSR-NH2 is a fluorescent peptide designed as a substrate for TNF-α converting enzyme (TACE; ADAM17), ADAM9, and ADAM10. This peptide utilizes fluorescence resonance energy transfer to monitor enzymatic activity, enabling quantification through changes in fluorescence intensity. It is a valuable tool for studying the roles of these metalloproteinases in various biological processes and may facilitate research in cancer biology and inflammatory diseases.

Cat. No.

A76865

CAS No.

193475-71-7

TNO211

Synonyms: Dabcyl-GABA-Pro-Gln-Gly-Leu-Glu(EDANS)-Ala-Lys-NH2

TNO211 is a fluorogenic substrate designed for the specific detection of matrix metalloproteinase (MMP) activity. It contains a cleavable Gly-Leu bond, allowing for the precise identification of MMPs, and features a fluorophore/quencher pair consisting of EDANS and Dabcyl. This reagent operates optimally at excitation/emission wavelengths of 340/485 nm, making it suitable for various applications in biochemical and molecular biology research focused on MMP functions.

Cat. No.

A76869

CAS No.

135662-06-5

Dnp-PYAYWMR

Dnp-PYAYWMR is a peptide substrate specifically designed to target matrix metalloproteinase 3 (MMP3). Upon cleavage by MMP3, it produces Dnp-PYA, which is nonfluorescent, and YWMR, a fluorophore detectable at 360 nm. This reagent is ideal for assessing MMP3 activity in biochemical assays, with fluorescence intensity measured at excitation/emission wavelengths of 328/350 nm following a 2-hour incubation period.