DGAT

Cat. No.

A69263

CAS No.

2091332-22-6

IONIS-DGAT 2Rx

Synonyms: ISIS 484137; ION-224

IONIS-DGAT 2Rx (ION-224) is a selective inhibitor of diacylglycerol O-acyltransferase 2 (DGAT2), an enzyme involved in triglyceride synthesis and lipid metabolism. This compound has demonstrated potential in research focused on atherosclerosis and related metabolic disorders. Its ability to modulate lipid accumulation makes it a valuable tool for investigating the pathophysiology of vascular diseases and the development of novel therapeutic strategies.

Cat. No.

A69265

CAS No.

1292294-31-5

Ent-Calquiquelignan E

Ent-Calquiquelignan E is a selective inhibitor of diacylglycerol acyltransferase 1 (DGAT1), demonstrating an IC50 of 71.5 μM. This flavonoid lignan compound is valuable for studies investigating metabolic disorders and related pathways. Its inhibitory action on DGAT1 may provide insights into lipid metabolism and potential therapeutic approaches for metabolic diseases.

Cat. No.

A69272

CAS No.

1231243-91-6

DGAT-1 inhibitor 3

DGAT-1 Inhibitor 3 is a selective inhibitor of diacylglycerol O-acyltransferase 1 (DGAT-1), exhibiting a potent inhibitory effect with an IC50 value of 0.038 µM. This compound is relevant for studies investigating lipid metabolism and has significant potential in obesity and diabetes research. Its activity can facilitate the understanding of DGAT-1's role in metabolic disorders and aid in the development of therapeutic strategies for associated diseases.

Cat. No.

A69274

CAS No.

1092067-85-0

JNJ-DGAT1-A

JNJ-DGAT1-A is a selective inhibitor of diacylglycerol acyltransferase 1 (DGAT1), which plays a critical role in triglyceride (TG) synthesis. By inhibiting DGAT1 activity, JNJ-DGAT1-A reduces the accumulation of triglycerides, making it a valuable tool for research into lipid metabolism and related disorders. This compound is utilized in studies aimed at understanding obesity, diabetes, and other metabolic diseases.

Cat. No.

A69284

CAS No.

232258-27-4

Roselipin 2B

Roselipin 2B is a selective inhibitor of diacylglycerol acyltransferases (DGAT), which play a critical role in lipid metabolism. It effectively suppresses DGAT activity in rat hepatic microcosms, making it a valuable tool for studying lipid synthesis and storage pathways. This compound can be utilized in research focused on metabolic disorders, obesity, and related metabolic diseases.

Cat. No.

A69288

CAS No.

232258-17-2

Roselipin 1A

Roselipin 1A is a selective diacylglycerol acyltransferase (DGAT) inhibitor. This compound demonstrates significant inhibition of DGAT activity in rat hepatic microcosm, which is critical for triglyceride synthesis and lipid metabolism. Roselipin 1A is applicable in studies investigating lipid homeostasis, obesity, and associated metabolic disorders.

Cat. No.

A69290

CAS No.

232258-18-3

Roselipin 1B

Roselipin 1B is an inhibitor of diacylglycerol acyltransferases (DGAT), which play a critical role in lipid metabolism. This compound effectively disrupts DGAT activity in rat hepatic microcosm, making it a valuable tool for studying lipid biosynthesis and related metabolic pathways. Its application is significant in research focused on obesity, metabolic disorders, and potential therapeutic strategies targeting lipid accumulation.

Cat. No.

A69292

CAS No.

232258-26-3

Roselipin 2A

Roselipin 2A is a specific inhibitor of diacylglycerol acyltransferases (DGAT), targeting the enzymatic activity involved in triglyceride synthesis. This compound has demonstrated efficacy in disrupting lipid metabolism in rat hepatic microcosm studies. It is valuable for research exploring metabolic pathways and potential therapeutic strategies for metabolic disorders.

Cat. No.

A69293

CAS No.

169181-29-7

Amidepsin B

Amidepsin B is a diacylglycerol acyltransferase (DGAT) inhibitor that plays a crucial role in lipid metabolism. By inhibiting DGAT, Amidepsin B effectively lowers triglyceride synthesis and can modulate metabolic pathways associated with obesity and insulin resistance. This compound is valuable for research in metabolic disorders, providing insights into lipid homeostasis and potential therapeutic strategies for metabolic diseases.

Cat. No.

A69294

CAS No.

169181-30-0

Amidepsin C

Amidepsin C is a selective inhibitor of diacylglycerol acyltransferase (DGAT), a key enzyme involved in triglyceride synthesis. By inhibiting DGAT, Amidepsin C plays a crucial role in reducing lipogenesis and may influence metabolic regulation. This compound has potential applications in research related to obesity, diabetes, and lipid metabolism.